Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells

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Items 101–190 of 190

1. A modular mathematical model of exercise-induced changes in metabolism, signaling, and gene expression in human skeletal muscle
   I.R. Akberdin, I.N. Kiselev, S.S. Pintus, R.N. Sharipov, A.Yu. Vertyshev, O.L. Vinogradova, D.V. Popov, F.A. Kolpakov · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
2. AMPK phosphosite profiling by label-free mass spectrometry reveals a multitude of mTORC1-regulated substrates
   William J. Smiles, Ashley J. Ovens, Dingyi Yu, Naomi X.Y. Ling, Andrea C. Poblete Goycoolea, Kaitlin R. Morrison, Emmanuel O. Murphy, Astrid Glaser, Sophie F. Monks O’Byrne, Scott Taylor et al. · 2025 · npj Metabolic Health and Disease
3. Tricin Delays Aging and Enhances Muscle Function via Activating AMPK-Mediated Autophagy in Diverse Model Organisms
   Yunfei Zhu, Xing‐Yue Zhou, Cai Lan, Yong‐Ping Wen, Haijun Fu, Zhichao Li, Yaping Li, Shiying Li, Feihong Huang, Long Wang et al. · 2025 · Journal of Agricultural and Food Chemistry
4. The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush
   Mingxing Teng, Damian W. Young, Zhi Tan · 2022 · Journal of Medicinal Chemistry
5. Inhibition of lactate dehydrogenase A by diclofenac sodium induces apoptosis in H e L a cells through activation of AMPK
   Avirup Malla, Suvroma Gupta, Runa Sur · 2024 · FEBS Journal
6. Increased regional activity of a pro-autophagy pathway in schizophrenia as a contributor to sex differences in the disease pathology
   Kathryn J. Bjornson, Amanda M. Vanderplow, Aishwarya I. Bhasker, Michael E. Cahill · 2024 · Cell Reports Medicine
7. A Highly Sensitive Non-Radioactive Activity Assay for AMP-Activated Protein Kinase (AMPK)
   Yan Yan, Xin Gu, H. Eric Xu, Karsten Melcher · 2017 · Methods and Protocols
8. New Insights Into Heat Shock Protein 90 in the Pathogenesis of Pulmonary Arterial Hypertension
   Liqing Hu, Rui Zhao, Qinglian Liu, Qianbin Li · 2020 · Frontiers in Physiology
9. In silico design and computational screening of berberine derivatives for potential antidiabetic activity through allosteric activation of the AMPK pathway
   Bibhuti Bhusan Kakoti, James H. Zothantluanga, Kangkan Deka · 2025 · In Silico Pharmacology
10. Gatekeeper–Activation Loop Cross-Talk Determines Distinct Autoactivation States of Symbiosis Receptor Kinase
    Avisek Bhattacharya, Anindita Paul, Dipanjan Chakrabarti · 2019 · Biochemistry
11. IGFBP‐2 stimulates calcium/calmodulin‐dependent protein kinase kinase 2 activation leading to AMP‐activated protein kinase induction which is required for osteoblast differentiation
    Gang Xi, Susan D’Costa, Christine Wai · 2019 · Journal of Cellular Physiology
12. cis-Banglene, a bangle (Zingiber purpureum)-derived bioactive compound, promotes mitochondrial biogenesis and glucose uptake by activating the IL-6/AMPK signaling pathway in C2C12 skeletal muscle cells
    Toshio Norikura, Shiori Kajiya, Mami Sugawara, Miwa Kubo, Yoshiyasu Fukuyama, Shin Sato · 2019 · Journal of Functional Foods
13. Serum Starvation Regulates Autophagy of Human Periodontal Ligament Cells Through Reactive Oxygen Species Mediated Adenosine Monophosphate-Activated Protein Kinase/Mechanistic Target of RAPAMYCIN Axis
    Mianxing Wei, Yujie Wu, Qian Yang, Zheng Zhou, Xiaomei Xu · 2025 · International Dental Journal
14. Inhibition of serotonin-Htr2b signaling in skeletal muscle mitigates obesity-induced insulin resistance
    Suhyeon Park, Hyeongseok Kim, Soyeon Shin, Yeongmin Kim, Yunwon Kang, Hye-Na Cha, So‐Young Park, Sang Kyu Park, Chang‐Myung Oh · 2025 · Experimental & Molecular Medicine
15. Recovery from FOLFOX chemotherapy-induced systemic and skeletal muscle metabolic dysfunction in mice
    Jessica L. Halle, Brittany R. Counts, Hector G. Paez, Dryden Ray Baumfalk, Quan Zhang, Junaith Shaik Mohamed, Evan Scott Glazer, Melissa Puppa, Ashley J. Smuder, Stephen E. Alway et al. · 2023 · American Journal of Physiology-Endocrinology and Metabolism
16. The Effect of PRKAA2 Variation on Type 2 Diabetes Mellitus in the Asian Population: A Systematic Review and Meta-Analysis
    Dita Maria Virginia, Iwan Dwiprahasto, Mae Sri Hartati Wahyuningsih, Dwi Aris Agung Nugrahaningsih · 2022 · Malaysian Journal of Medical Sciences
17. Exploiting Cancer Dormancy Signaling Mechanisms in Epithelial Ovarian Cancer Through Spheroid and Organoid Analysis
    Emily J. Tomas, Yudith Ramos Valdés, Jennifer Davis, Bart Kolendowski, Adrian V. Buensuceso, Gabriel E. DiMattia, Trevor G. Shepherd · 2025 · Cells
18. Melatonin alleviates high glucose-induced cardiomyocyte injury through suppressing mitochondrial FUNDC1-DRP1 axis
    Junyi Zheng, Lili Zhao, Yingying Zhang, Wenbin He, Xukun Guo, Jixiang Wang · 2024 · Journal of Pharmacy and Pharmacology
19. Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise in mice
    Paola Pinto-Hernández, Manuel Fernández‐Sanjurjo, Daan Paget, Xurde M. Caravia, David Roiz‐Valle, Juan Castilla‐Silgado, Sergio Díez‐Robles, Almudena Coto-Vilcapoma, David Fernandez-Vivero, Pau Gama-Pérez et al. · 2025 · Molecular Metabolism
20. ICP5249 Promotes Hair Growth by Activating the AMPK-Autophagy Signaling Pathway
    Jung Ok Lee, Yu Jin Kim, You Na Jang, Jung min Lee, Kayoung Shin, Sekyoo Jeong, Hwa-Jee Chung, Beom Joon Kim · 2024 · Journal of Microbiology and Biotechnology
21. AMPK
    Cansu Karabiyik, Mariella Vicinanza, David Chaim Rubinsztein · 2021 · Elsevier eBooks
22. LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis
    Shuang Qu, Qiao Liao, Cheng Jun Yu, Yue Chen, Han Luo, Xuewei Xia, Duofen He, Zaicheng Xu, Pedro A. José, Zhuxin Li et al. · 2022 · Biomolecules and Biomedicine
23. AMPK: an enzyme that may be effective in cancer and metabolic diseases
    Sümeyye Güney-Kalkan, Meltem Ceylan‐Ünlüsoy · 2025 · Discover Oncology
24. AMPK–mTORC1 pathway mediates hepatic IGFBP-1 phosphorylation in glucose deprivation: a potential molecular mechanism of hypoglycemia-induced impaired fetal growth
    Jenica H. Kakadia, Muhammad U Khalid, Ilka U. Heinemann, Victor K. M. Han · 2024 · Journal of Molecular Endocrinology
25. An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection
    Zachary Walter, Minghua Li, Melissa Molho, Lauren Berish, Andrew Isopi, Mary O’Mara, Mark Dittmar, Chike Nwaezeapu, Alicia Richards, Martin McCullagh et al. · 2025 · Cell Reports
26. Salicylic acid engages central metabolic regulators SnRK1 and TOR to govern immunity by differential phosphorylation of NPR1
    Yixuan Chen, John Withers, Yulin Sun et al. · 2026 · Cell
27. AMP‐activated protein kinase contributes to myofibrillar protein hydrolysis in bovine skeletal muscle through postmortem mitochondrial dysfunction‐induced apoptosis
    Jibing Ma, Cheng Chen, Qunli Yu, Ling Han · 2021 · Journal of Food Biochemistry
28. Markers of Hypoxia and Metabolism Correlate With Cell Differentiation in Retina and Lens Development
    Tom A. Gardiner, Tiarnan Branagh, Nuala Tipping, Denise McDonald · 2022 · Frontiers in Ophthalmology
29. AMPK-mediatedhy Poglycemic Effect of Banana Stem Juice on Type 2 Diabetes
    Nguyen Thi Kim Dong, Phung Thanh Huong · 2020 · Biosciences Biotechnology Research Asia
30. Dysregulated pancreatic lipid phenotype, inflammation and cellular injury in a chronic ethanol feeding model of hepatic alcohol dehydrogenase-deficient deer mice
    Mukund P. Srinivasan, Kamlesh K. Bhopale, Anna A. Caracheo, Lata Kaphalia, Vsevolod L. Popov, Paul J. Boor, Bhupendra S. Kaphalia · 2023 · Life Sciences
31. Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of IP6K1 and repression of myo -inositol-3-P synthase
    Pablo Lazcano, Michael W. Schmidtke, Chisom Onu, Miriam L. Greenberg · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
32. Ascorbic acid relieves neuropathic pain and depressive behavior by reducing inflammation and activating antioxidant responses
    Xin Li Yao, Mengwei Zhang, Shuang Wang · 2025 · Molecular Pain
33. Epibrassinolide impaired colon tumor progression and induced autophagy in SCID mouse xenograft model via acting on cell cycle progression without affecting endoplasmic reticulum stress observed in vitro
    Pınar Obakan Yerlikaya, Kaan Adacan, Ayşe Karatuğ Kaçar, Ajda Çoker Gürkan, Elif Damla Arısan · 2022 · The International Journal of Biochemistry & Cell Biology
34. Mitochondrial Bioenergetics and Cardiac Rehabilitation: Bridging Basic Science and Clinical Practice
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35. AMPK Activation Enhances Neutrophil's Fungicidal Activity in Vitro and Improves the Clinical Outcome of Fusarium solani Keratitis in Vivo
    Wei Si, Yanting Xie, Junlu Dong, Chunmei Wang, Fenfen Zhang, Juan Yue, Shoujun Jian, Jingjing Wei, Susu Liu, Liya Wang et al. · 2022 · Current Eye Research
36. Low-Dose Metformin Treatment Reduces In Vitro Growth of the LL/2 Non-small Cell Lung Cancer Cell Line
    Nicole L. Stott, Didier Dréau, Ian Marriott, Jeanette M. Bennett, Michael J. Turner, Susan Tsivitse Arthur, Joseph S. Marino · 2022 · Biomedicines
37. Bacteroides fragilis Enterotoxin Induces Autophagy through an AMPK and FoxO3-Pathway, Leading to the Inhibition of Apoptosis in Intestinal Epithelial Cells
    Su Hyuk Ko, Jun Ho Choi, Jung Mogg Kim · 2023 · Toxins
38. New insights into reductive stress responses and its clinical relation in cancer
    Suman Kumar Ray, Sukhes Mukherjee · 2025 · Tissue and Cell
39. Oblique-incidence reflectivity difference technology identifies the antiviral drug Ribavirin as an inhibitor of lung tumor progression by targeting AMPK signaling
    Jiani Gao, Yiwen Zhang, Yicheng Wang, Dong Xie, Yijiu Ren · 2025 · Journal of Pharmaceutical Analysis
40. Novel AMP-activated protein kinase activators and their potential for mitigating renal injury and fibrosis
    Geoff Harley, Peter F. Mount · 2025 · Journal of Pharmacology and Experimental Therapeutics
41. Wogonin, a bioactive flavonoid from Scutellaria baicalensis, alleviates alcoholic pancreatitis via AMPK-mediated TFEB activation
    Zhen Qin, Xiaohong Sun, Jing-min Zeng et al. · 2025 · Journal of Advanced Research
42. The Role of PKGIα and AMPK Signaling Interplay in the Regulation of Albumin Permeability in Cultured Rat Podocytes
    Patrycja Rachubik, Dorota Rogacka, Irena Audzeyenka, Maria Szrejder, Anna Topolewska, Michał Rychłowski, Agnieszka Piwkowska · 2023 · International Journal of Molecular Sciences
43. Targeting AMPK/eNOS pathway and mitochondria by sonlicromanol protects myocardial cells against ischemia-reperfusion injury
    Kun T. Liao, Fangfei Huang, Xing Xie, Linhui Li · 2023 · General Physiology and Biophysics
44. Pioglitazone treatment increases the cellular acid-labile and protein-bound sulfane sulfur fractions
    Mohammad Zahidul Islam, Rodney E. Shackelford · 2023 · Biochemical and Biophysical Research Communications
45. An AMPK biosensor for Caenorhabditis elegans
    Lynly Carman, Ryan J Schuck, Edwin Li, Matthew D. Nelson · 2022 · PubMed Central
46. Persistent Activation of Renal Autophagy Contributes to Nephropathy in Murine Glycogen Storage Disease Type Ia
    Chul Lee, Kunal Pratap, Sudeep Gautam, Lisa Zhang, Hung Dar Chen, Yoke Peng Loh, Brian C. Mansfield, JANICE YANG CHOU · 2025 · Journal of Inherited Metabolic Disease
47. AMPK agonism optimizes the in vivo activation and antileukemic efficacy of chimeric antigen receptor T cells
    Erica Lynne Braverman, Mengtao Qin, Elisabet Ampudia-Mesias, Herbert Tres Schuler, Harrison Brown, Lukas Murdych, Ann Titus, Allison MacLean, Bhavya Kanagala, Christopher Wittmann et al. · 2025 · Journal for ImmunoTherapy of Cancer
48. The regeneration model of aging and its practical implications
    Erik Dassoff · 2026 · Discover Medicine
49. Translational control of AMPK activity in melanoma
    Natália Vadovičová, Anna Lešková, Katerina Kozdonova, Karolina Smolkova, Barbora Valčíková, Filip Kafka, David Potěšil, Zbyněk Zdráhal, Ondřej Vacek, Ráchel Víchová et al. · 2026 · Cell Communication and Signaling
50. AMPK γ-Subunit Isoform Switching Governs Temozolomide Resistance and Survival in Glioblastoma
    Shweta Dongre, Arpit Sharma, Naveen Soni, Bhawana Bissa · 2026 · Cells
51. Acute amyloid-β exposure disrupts insulin signaling in hCMEC/D3 blood–brain barrier endothelial cells
    Douglas A. Nelson, Suresh Kumar Swaminathan, Vaishnavi Veerareddy, Hannah S. Seo, Samira M. Azarin, Krishna R. Kalari, Karunya K. Kandimalla · 2026 · Fluids and Barriers of the CNS
52. Honokiol, a Neolignan from Magnolia officinalis, Attenuated Fructose-Induced Hepatic Fat Accumulation by Improving Intestinal Barrier Function in Mice
    Anja Baumann, Verena Freutsmiedl, Julia Jelleschitz, Raphaela Staltner, Annette Brandt, Daniel Schachner, Verena Maria Dirsch, Ina Bergheim · 2025 · Journal of Nutrition
53. AMP-activated protein kinase is necessary for Treg cell functional adaptation to microenvironmental stress
    Manuel A. Torres Acosta, Nurbek Mambetsariev, Carla Patricia Reyes Flores, Kathryn A. Helmin, Qianli Liu, Anthony M. Joudi, Luisa Morales‐Nebreda, Jonathan K. Gurkan, Kathleen Cheng, Hiam Abdala‐Valencia et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
54. AMPK agonism optimizes the in vivo persistence and anti-leukemia efficacy of chimeric antigen receptor T cells
    Erica Lynne Braverman, Mengtao Qin, Herbert Schuler et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
55. Illuminating compartmentalized AMPK signaling in single cells
    Arnav Jhawar, Kasey Parks, Danielle L. Schmitt · 2026 · Biochemical Journal
56. AMPK phosphorylation proceeds through hierarchical proteoform cascades revealed by integrated mass spectrometry
    Boris Krichel, Hsin‐Ju Chan, Liam J. Bandura, Zhan Gao, Man‐Di Wang, Holden T. Rogers, Sean J. McIlwain, Charlotte Uetrecht, Ying Ge · 2026 · Science Advances
57. Effect of fermented cassava tuber on the gene expression of PI3K/Akt signaling and AMPK pathway in STZ-NA-induced diabetic rats
    Rio Jati Kusuma, Desty Ervira Puspaningtyas, Puspita Mardika Sari · 2021 · Nutrition & Food Science
58. AMPK-SP1–Guided Dynein Expression Represents a New Energy-Responsive Mechanism and Therapeutic Target for Diabetic Nephropathy
    Jillian Williquett, Chantal Allamargot, Hua Ling Sun · 2024 · Kidney360
59. Proteomic profiling of metformin effects in 3T3‐L1 adipocytes by SILAC‐based quantification
    Sunkyu Choi, Rudolf Engelke, Neha Goswami, Frank Schmidt · 2022 · PROTEOMICS
60. Inhibition of Lactate Dehydrogenase A (LDH-A) by Diclofenac Sodium Induces Apoptosis in HeLa Cells by Activation of AMPK
    Avirup Malla, Suvroma Gupta, Runa Sur · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
61. miR-29a-3p, a new myokine orchestrating resistance exercise via coordinated metabolic responses
    Paola Pinto-Hernández, Manuel Fernández‐Sanjurjo, Daan Paget, Xurde M. Caravia, David Roiz‐Valle, Juan Castilla‐Silgado, Sergio Díez‐Robles, Almudena Coto-Vilcapoma, Pau Gama-Pérez, Pablo M. García-Rovés et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
62. Regulation and Function of the Phosphatase PHLPP2 in Leukemia
    Yan Yan · 2017 · University of Minnesota Digital Conservancy (University of Minnesota)
63. Maternal Intake Restriction Programs the PKA-CREB Pathway to Regulate Energy Metabolism, CLOCK and mTOR Signals in the Skeletal Muscles of Goat Offspring
    Xiaoling Zhou, Qiongxian Yan, Hong Yan Yang, Ao Ren, Zhixiong He, Zhiliang Tan · 2021 · Research Square
64. Importância da proteína quinase ativada por AMP (AMPK) na regulação da sinalização do TGF-β e diferenciação das células T reguladoras
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65. Mechanism of the Fungal-like Particles in the Inhibition of Adipogenesis in 3t3-l1 Adipocytes
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66. The development and application of a ChIP and MeDIP assay to determine a link between epigenetics and metabolism in ovarian cancer progression
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67. Stress granules and Sec bodies: From Drosophila to mammalian cells.
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68. Combination Therapy of Green Tea and Green Coffee on Improving Cardiomyocyte Metabolism Through Increased Expression of AMPK and AKT Genes in Metabolic Syndrome Model Rats
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69. Activated AMP-protein kinase (pAMPK) is overexpressed in human somatotroph pituitary adenomas
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70. Pioglitazone as a Possible Treatment for Ataxia-Telangiectasia
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71. AMPK Signaling in Cancer
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72. Maternal swimming with overload allied to postnatal high-fat, high-sugar diet induce subtle impairment on rat offspring’s ovarian redox homeostasis
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73. Role of Ceramide in Remodeling of Skeletal Muscle Myosin Phenotype during Disuse: Possible Mechanisms
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74. Electron transport chain complex I and mitochondrial fusion regulate ROS for differentiation in Drosophila neural stem cells
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75. AMPK Signaling in Cancer
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76. Cannabinoid/lysophosphatidylinositol-sensing G-protein coupled receptor 55 promotes intestinal tight junction assembly and its mechanistic insights
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77. Differences in intrinsic cellular O-GlcNAcylation impact response to metabolic stress
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78. L-Arginine supplementation modulates L-Arg/NO metabolic processes and AMPK/ACC-1 signalling in BNL CL2 hepatocytes
    Saranya Prashath, Christopher Mark Smales · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
79. Spirulina Preconditioning Attenuates Ischemia–Reperfusion Injury in a Steatotic Rat Liver Model
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80. 5-Hydroxytryptamine 2B receptor antagonism restores ATP and reduces tubulointerstitial fibrosis in the renal cortices of aged mice
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81. Rôle des vésicules extracellulaires dans les altérations de l'homéostasie musculaire au cours du développement de l'insulino-résistance
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82. Biochemical characterization of mTORC1 regulation by glutamine metabolism
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83. Identification des mécanismes moléculaires de l'hépatoprotection du foie de rat isolé
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84. Glucose signaling through Snf1/AMPK in Saccharomyces cerevisiae : mechanistic insights from 2-deoxyglucose-resistant mutants
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85. Ursocholic acid ameliorates hepatic steatosis via direct AMPK activation in preclinical models of MASLD
    Yong Li, Ze-Jie Zeng, Anqi Ye · 2026 · European Journal of Pharmacology
86. Is Hepatic Cannabinoid 1 Receptor a Key Driver of Obesity? Implications of the Weight‐Reducing Efficacy of the Hepatotropic Inverse Agonist TM38837
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87. Toward a gut-AMPK axis: the microbiome and AMPK signaling in nutrition and healthy aging
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88. Nutrients and Their Role in Autophagy Regulation.
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89. AMPK signaling in cancer: Molecular insights and therapeutic opportunities
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90. The AMPK signaling pathway in cell metabolism and human diseases
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