Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases

Cited by (160)

Items 101–160 of 160

1. Obeticholic Acid Inhibit Mitochondria Dysfunction Via Regulating ERK1/2‐DRP Pathway to Exert Protective Effect on Lipopolysaccharide‐Induced Myocardial Injury
   Huijie Miao, Xiaomeng Tang, Yun Cui, Jingyi Shi, Xi Xiong, Chunxia Wang, Yucai Zhang · 2024 · Advanced Biology
2. Plasma derived cell-free mitochondrial DNA originates mainly from circulating cell-free mitochondria
   Benoit Roch, Ekaterina Pisareva, Cynthia Sanchez, Brice Pastor, Rita Tanos, Alexia Mirandola, Thibault Mazard, Zahra Al Amir Dache, Alain Roger Thierry · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
3. Metformin regulates cellulase production in Trichoderma reesei via calcium signaling and mitochondrial function
   Jiajia Wang, Yumeng Chen, Jiawei Cong, Wei Wang · 2024 · Microbial Cell Factories
4. Cell-Free Nucleic Acids in Cardiovascular Disease: From Biomarkers to Mechanistic Drivers and Therapeutic Opportunities
   Hannah Morgan, Keara Little, Suchandrima Dutta, Sophie Chen, Jiantao Gong, Siddu Koduri, Asma Raja, Wendy Lin, Kanishka Saini, Riya Bhullar et al. · 2025 · Cells
5. Toll-like receptor 9 signaling after myocardial infarction: Role of p66ShcA adaptor protein
   Anton Baysa, Azzam A. Maghazachi, Kristin Larsen Sand, Marika Campesan, Tania Zaglia, Marco Mongillo, Marco Giorgio, Fabio Di Lisa, Lars Lysgaard Gullestad, Lars Henrik Mariero et al. · 2022 · Biochemical and Biophysical Research Communications
6. Microfluidic-based cardiovascular systems for advanced study of atherosclerosis
   Huiyuan Zheng, Lei Tai, Chengbin Xu, Weijiang Wang, Qingming Ma, Wentao Sun · 2024 · Journal of Materials Chemistry B
7. A single muscle contusion promotes an immediate alteration in mitochondrial bioenergetics response in skeletal muscle fibres with different metabolism
   Diane Duarte Hartmann, Débora Farina Gonçalves, Pâmela Carvalho da Rosa, Rodrigo Pereira Martins, Aline Alves Courtes, Jeferson Luís Franco, Félix Alexandre Antunes Soares, Gustavo Orione Puntel · 2020 · Free Radical Research
8. Circulating Oxidized mtDNA is Associated Broadly with Cardiovascular Disease in a Longitudinal Cohort Study of Psoriasis
   Sundus S. Lateef, Grace Ward, Haiou Li, Carla J. Pantoja, Elizabeth M. Florida, Christin G. Hong, Justin A. Rodante, Andrew Keel, Marcus Y. Chen, Alexander V. Sorokin et al. · 2023 · JID Innovations
9. Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing Glycolysis via Distinct Opa1 Processing
   Abdennour Douida, Frank Batista, Pál Botó, Zsolt Regdon, Agnieszka Robaszkiewicz, Krisztina Tar · 2021 · International Journal of Molecular Sciences
10. Low levels of supercoiled mitochondrial DNA are involved in heart failure induced by transverse aortic constriction in mice via an inflammatory response mediated by ZBP1
    Fan Yu, Lu Yang, Rongjie Zhang, Fajia Hu, Yong Yuan, Zixu Wang, Wei Peter Yang · 2024 · Experimental Cell Research
11. Mitochondrial Genetics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association
    Jessica L. Fetterman, Patrick Francis Chinnery, Rebecca McClellan, Douglas C. Wallace, Anu Suomalainen, Tiina H. Ojala, Samantha C. Lewis, Scott W. Ballinger · 2025 · Circulation
12. The Degree of Cardiac Remodelling before Overload Relief Triggers Different Transcriptome and miRome Signatures during Reverse Remodelling (RR)—Molecular Signature Differ with the Extent of RR
    Patrícia Gonçalves‐Rodrigues, Daniela Miranda‐Silva, Xidan Li, Cláudia Sousa-Mendes, Ricardo Martins-Ferreira, Zaher Elbeck, Adelino Ferreira Leite-Moreira, Ralph Knöll, Inês Falcão‐Pires · 2020 · International Journal of Molecular Sciences
13. Using Two-Dimensional Intact Mitochondrial DNA (mtDNA) Agarose Gel Electrophoresis (2D-IMAGE) to Detect Changes in Topology Associated with Mitochondrial Replication, Transcription, and Damage
    Jill E. Kolesar, Brett A. Kaufman · 2020 · Methods in molecular biology
14. Postoperative Plasma Mitochondrial DNA and Cytokine Profiles of Elderly Patients Undergoing Minimally Invasive Aortic Valve Replacement
    Francisco Estévez, Maria E. Serrano-Teruel, Fernando Fernandez-Rodriguez, Alberto Bouzas‐Mosquera, Mercedes Fernández-Moreno, Paula Diéguez Garcia, Jose Joaquin Cuenca-Castillo, Víctor Bautista‐Hernández · 2019 · The Thoracic and Cardiovascular Surgeon
15. The Role of Sterile Inflammation in Thrombosis: Consequences for Cardiovascular Disease and COVID‐19
    Gausal Azam Khan, Mashael Abdulhalim Huwaikem, Kaustav Chowdhury, Humood Fahm Albugami, Arjun Kumar Ghosh · 2025 · Mediators of Inflammation
16. Mitochondrial transfer as a driver of immune microenvironment remodeling
    Xiaoya Zhang, Danmei Zhang, Jin Guo, Chunxia Shi, Zuojiong Gong · 2026 · Frontiers in Immunology
17. Association between healthy dietary patterns and markers of oxidative stress in the Sister Study
    Brittany Crawford, Susan E. Steck, Dale P. Sandler, Hazel B. Nichols, Ginger L. Milne, Yong‐Moon Park · 2023 · European Journal of Nutrition
18. Does cardiac impairment develop in ischemic renal surgery in rats depending on the reperfusion time?
    Priyanka N. Prem, Gino A. Kurian · 2024 · Heliyon
19. GDF11 alleviates cardiac ischemia/reperfusion injury by suppressing the mtDNA damage-inflammatory response axis
    Dan Zhao, Zihui Wang, Yanyan Chen, Zhiwei Peter Wang, Yinxiang Wei, Lijie Zhang, Yinxiang Wei, Shulian Li, Xianjie Zheng, Guoliang Wang et al. · 2025 · European Journal of Pharmacology
20. Emerging microbiome–mitochondria crosstalk in host defense and infectious diseases: mechanistic insights into NLRP3 inflammasome activation and mtDNA-mediated immunomodulation
    Xinxing Lu, W. W. Sun, Daowei Zhang, Bin Hou, Huiyu Tai, Wenqing Yu, Xuehua Pu · 2026 · Frontiers in Cellular and Infection Microbiology
21. Elamipretide in the Management of Barth Syndrome: Current Evidence and a Case Report
    Neil Jacob, Daniel Schecter, Molly Marshall, Neha Bansal, Jacqueline M. Lamour, Hilary J. Vernon, Éva Morava, Ibrahim Elsharkawi · 2025 · Molecular Genetics and Metabolism
22. Sea buckthorn (Hippophae rhamnoides L.) oil exhibits antifungal activity against Aspergillus flavus via disrupting mitochondrial function
    Yanhua Xin, Jie Yang, Sanhu Zhao, Kewen Chen, Yaqin Zhao, Tie-Dan Zhang, Jianhua Zhang · 2022 · Czech Journal of Food Sciences
23. Multiparametric approach to assess the disease severity and progression of cutaneous leishmaniasis infection
    Shumaila Naz, Aiman Aroosh, Naeem Raza, Arshad Islam, Yusuf Özbel, Seray Ozensoy Töz, Haroon Ahmed, Shahid Waseem · 2022 · Acta Tropica
24. Urinary Mitochondrial Deoxyribonucleic Acid: A Novel Biomarker of Coronavirus Disease 2019-associated Acute Kidney Injury in Renal Transplant Recipients
    Brijesh Yadav, Narayan Prasad, Ravi Shanker Kushwaha, Manas Ranjan Patel, DHARMENDRA SINGH BHADAURIA, Anupma Kaul · 2023 · Indian Journal of Transplantation
25. Associations of circulating cell-free DNA, C-reactive protein, and cardiometabolic risk among low-active smokers with elevated depressive symptoms
    Teresa E. Daniels, Emily K. Zitkovsky, Zachary J. Kunicki, Destiny J. Price, Abigail L. Peterson, Phyllis A. Dennery, Hung‐Teh Kao, Lawrence H. Price, Audrey R. Tyrka, Ana M. Abrantes · 2022 · Brain Behavior & Immunity - Health
26. Mitochondrial Quality Control in Macrophages During Cardiovascular Disease
    Ryan Falconer, Emily Anne Day · 2026 · Canadian Journal of Cardiology
27. The Role of Interferons in Cardiac Remodeling after Acute Myocardial Infarction
    Ferhat Eyyüpkoca, Nilnur Eyerci, Can Özkan, Ajar Koçak, Murat Gök, Karabekır Ercan · 2022 · Journal of College of Physicians And Surgeons Pakistan
28. Serine 39 in the GTP ‐binding domain of Drp1 is involved in shaping mitochondrial morphology
    Marvi Ghani, Bernadett Szabó, Mahmoud Alkhatibe, Hailemariam Amsalu, Zohar Peleg, Eszter Anna Janka, János András Mótyán, Krisztina Tar · 2024 · FEBS Open Bio
29. Mitochondrial DNA copy number reduction via in vitro TFAM knockout remodels the nuclear epigenome and transcriptome
    Julia Nguyen, Phyo Wei Win, Tyler Shin Nagano, Elly H. Shin, Charles Newcomb, Dan E. Arking, Christina A. Castellani · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
30. Epigenetics of mitochondrial and inflammation in cardiac fibrosis
    Huanhuan He, Li-Chan Lin, Zhenyu Liu, Peng Liu, Sui Mao, Wei Cao, Jianyuan Zhao, Hui Tao · 2025 · Cellular Signalling
31. A novel spontaneous rat model of chronic kidney disease with mitochondrial dysfunction driven by thioredoxin insufficiency
    Iori Ohmori, Mamoru Ouchida, Yoshiko Hada, Haruhito Adam Uchida, Shinya Toyokuni, Tomoji Mashimo · 2026 · Translational research
32. Molecular and imaging biomarkers in myocardial ischemia/reperfusion injury: from pathogenetic mechanisms to therapeutic targeting
    Athina Nasoufidou, Marios Georgios Bantidos, Christos Kofos, Nikolaos Stalikas, Andreas Mitsis, Panagiotis Stachteas, Paschalis Karakasis, Maria Fasoula, Barbara Fyntanidou, George Kassimis et al. · 2026 · Expert Review of Cardiovascular Therapy
33. Immunological Reprogramming in Cardiomyopathies: From Cardiomyocyte Injury to Disease of the Cardiac Immune Ecosystem
    Tomasz Kamil Urbanowicz, Krzysztof Jerzy Filipiak · 2026 · Cells
34. INVESTIGATION OF THE EFFECTIVENESS OF MAGNESIUM SULFATE USE IN THE COMPOSITION OF FLUID RESUSCITATION FOR THE PREVENTION OF CELLULAR MEMBRANE DAMAGE IN PATIENTS SUFFERING FROM POLYTRAUMA UNDER CONDITIONS OF HYPOVOLEMIC TRAUMATIC SHOCK AND ISCHEMIA
    O. V. Biletskiy, M. A. Stupnitskiy · 2019 · Bulletin of Problems Biology and Medicine
35. Disruption of the microphysiological niche alters matrix deposition and causes loss of mitochondrial Ca 2+ control in skeletal muscle fibers
    Charlotte Gineste, Sonia C. Youhanna, Sabine U. Vorrink, Sara Henriksson, Andrés Hernández, Arthur J. Cheng, Thomas Chaillou, Andreas Buttgereit, Dominik Schneidereit, Oliver Friedrich et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
36. Endothelial RRM2B-dependent mitochondrial DNA signalling drives doxorubicin-cardiotoxicity
    SILVIA GRAZIANI, Altea Bonello, Raquel Brañas Casas, Giovanni Risato, Natascia Tiso, Francesco Argenton, Chiara Rampazzo, Satoko Shinjo, Margherita Zamberlan, Nicola Facchinello et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
37. Evidence of inflammatory disorders in cardiac patients
    Anika Niambi Al-Shura · 2020 · Elsevier eBooks
38. “Sensing Danger”
    Andrew N. Carley, E. Douglas Lewandowski · 2020 · Circulation
39. Quantitation and Characterization of Cell-Free Mitochondrial DNA in Plasma by Deep Sequencing
    Grant T. Daly, Viktor M. Pastukh, Yong B. Tan, C. Michael Francis, C. Zack Aggen, S. Chris Groark, Carson Edwards, Mohammad Hamo, Jon David Simmons, Matthew Kutcher et al. · 2021 · Research Square
40. Mechanisms of organic dust induced neuroinflammation
    Nyzil Massey · 2021
41. Plasma Mitochondrial DNA Clearance by Continuous Venovenous Haemofiltration in Critically Ill Patients
    Yujing Wang, Ze-Peng Duan, Hua Ling, Qiong Li, Xingui Dai · 2024 · Intensive Care Research
42. Carnosinylation of Cardiac Antigens Attenuates Immunogenic Responses and Improves Function in Failing Hearts
    Benjamin Doelling, Mamata Chaudhari, David Hoetker, Kenneth R. Brittian, Yibing Nong, Jonah Stephan, Ibrahim Jouja, Helen I Janis, Thomas C. Mitchell, Marcin Wysoczynski et al. · 2026 · Journal of the American Heart Association
43. Additional file 1 of Intravitreal injection of mitochondrial DNA induces cell damage and retinal dysfunction in rats
    Yue Guo, 干德康, Hu, Fangyuan, Cheng, Yun, Yu, Jian, Boya Lei, Shu, Qinmeng, Gu, Ruiping, Xu, Gezhi · 2022 · Figshare
44. Additional file 3 of Mitochondrial DNA drives noncanonical inflammation activation via cGAS–STING signaling pathway in retinal microvascular endothelial cells
    Yue Guo, Gu, Ruiping, 干德康, Hu, Fangyuan, Li, Gang, Xu, Gezhi · 2020 · Figshare
45. Additional file 2 of Mitochondrial DNA drives noncanonical inflammation activation via cGAS–STING signaling pathway in retinal microvascular endothelial cells
    Yue Guo, Gu, Ruiping, 干德康, Hu, Fangyuan, Li, Gang, Xu, Gezhi · 2020 · Figshare
46. Additional file 2 of Intravitreal injection of mitochondrial DNA induces cell damage and retinal dysfunction in rats
    Yue Guo, 干德康, Hu, Fangyuan, Cheng, Yun, Yu, Jian, Boya Lei, Shu, Qinmeng, Gu, Ruiping, Xu, Gezhi · 2022 · Figshare
47. Polycyclic aromatic hydrocarbon exposure and mitochondrial DNA copy number: Opposing roles of oxidative stress and inflammation
    Si Zhou, Wenzhe Su, Lingli Zeng, Jia He, Jun Yuan, Rongfei Peng, Juntao Li, Lei Tan · 2026 · Environmental Pollution
48. Rôles du stress oxydant et de ses dérivés dans les mécanismes physiopathologiques de l’insuffisance cardiaque
    Yohan Santin · 2019 · theses.fr (ABES)
49. Mitochondrial dysfunction in endothelial senescence: implications for vascular remodeling and therapeutic strategies
    Wen Li, Jinteng Liu, Xinyin Fu, Yu Liu, Yiqian Xu, Xingyue Fang, Qingyun Guo, Qibing Liu · 2026 · Archives of Pharmacal Research
50. Circulating Mitochondrial DNA Aggravates Post-Ischemic Functional and Metabolic Recovery in an Isolated Rat Heart Model of Donation After Circulatory Death
    Maria N. Sanz, Maria Arnold, Adrian Segiser, Michelle Hofmann, Matthias Siepe, SL Longnus · 2026 · International Journal of Molecular Sciences
51. Preliminary exploration of dynamic changes in circulating mitochondrial DNA (ΔmtDNA) as a prognostic biomarker for acute ST-segment elevation myocardial infarction patients: a prospective observational study
    Shipeng Tian, Lili Wang, Dongxiao Wang, Shiru Bai, Xian Wang · 2026 · BMC Cardiovascular Disorders
52. Finerenone after FINEARTS-HF: evidence boundaries and implementation in heart failure with LVEF ≥40%
    Shihang Feng, Hongguang Jin · 2026 · Frontiers in Cardiovascular Medicine
53. Reverse cardio-oncology: neuroendocrine axis activation and cardiovascular-disease-derived factors synergistically remodel the tumor microenvironment
    Siyu Ji, Nan Zhang, Xin Hu · 2026 · Cellular Oncology
54. Factors Modulating Mitochondrial Function after Arterial Injury: Past-to-Present Evidence for the Devising of Future Preventive and Therapeutic Strategies
    Chollakarn Varopas, Thawatchai Khuanjing, Ob-Uea Homchan, Siriporn Chaisin Chattipakorn, Nipon Chattipakorn · 2026 · Journal of Cardiovascular Translational Research
55. Endothelial Mitochondrial Dysfunction in INOCA and Coronary Microvascular Dysfunction: Mechanisms, Sex Differences, and Therapeutic Implications
    Roko Šantić, Lovre Martinovic, Marko Kumrić, Nikola Pavlović, Dinko Martinović, Lovre Jukić, Zenon Pogorelić, Joško Božić · 2026 · Journal of Cardiovascular Development and Disease
56. Association of mitochondrial DNA haplogroup, oxidative DNA damage and inflammatory markers in middle-aged adults
    Jessica T. Smith, Nicole Noren Hooten, Nicolle A. Mode, Alan B. Zonderman, Ngozi Ezike, Michele K. Evans · 2026 · International Journal of Radiation Biology
57. Redox Phenotyping of the Donor Heart: A New Paradigm for Precision Heart Transplantation
    Tomasz Kamil Urbanowicz, Mariusz Kowalewski, Giuseppe Maria Raffa, Beata Krasińska, Calogera Pisano, Vincenzo Nuzzi, Mansur Rahnama, Piotr Suwalski, Zbigniew Krasiński, Ewelina Grywalska · 2026 · Antioxidants
58. Endothelial glycocalyx damage markers as early predictors of pneumonia after thoracic aortic surgery
    Mariia L. Diakova, Yu. S. Svirko, Д. С. Панфилов, Т. Е. Суслова, Yu. K. Podoksenov, U. A. Ladik, A. M. Boĭko, Boris N. Kozlov · 2026 · Russian Journal of Cardiology and Cardiovascular Surgery
59. Admission serum mitochondrial DNA relative abundance is associated with angiographic no-reflow or slow-flow after primary percutaneous coronary intervention in STEMI
    Shipeng Tian, Lili Wang, Qian Jia, Dongxiao Wang, Yaqing Shi, Gaoying Li · 2026 · Journal of Thrombosis and Thrombolysis
60. Cardiomyocyte-targeted HSP60 modulates myocardial remodeling pathways and peripheral blood mononuclear cell mitochondrial membrane potential in hypertensive diabetic rats
    Anastasia P. Sklifasovskaya, Mikhail Lvovich Blagonravov, Азова Мадина Мухамедовна, R. M. Karpov, Vera S. Ovechkina, S. K. Andrianova, Dmitriy B. Staroverov, Vsevolod Vadimovich Belousov, Andrey A. Mozhaev · 2026 · Journal of Physiology and Biochemistry