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The oxidation of pyruvate in pigeon breast muscle
Open accessAbstract
PYRUVATE is very readily oxidized in animal tissues, yet little is known about the immediate products of its oxidation.Such oxidative reactions of pyruvate as are known to occur-dismutation, formation of succinate, acetate or ketone bodies-are side reactions whose significance varies from tissue to tissue: in no tissue can these reactions account for the total oxidation, and in some tissues,
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“In subsequent work, Krebs (4) determined that the two carbon atoms that condensed with OAA to form citrate were derived from pyruvate and that oxygen consumption in muscle increases when pyruvate is added.”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [4]
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Metadata
- Authors
- Krebs, H. A., & Eggleston, L. V.
- Affiliations
- University of Sheffield (GB)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1940-03-01
- Volume
- 34
- Issue
- 3
- Pages
- 442-459
- ISSN
- 0306-3283 (ISSN-L)
- PMC
- PMC1265297
- OpenAlex
- W80730550
- Cited by
- 256
- References
- 9
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 3 · 2022: 5 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2014: 2
- FWCI
- 10.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Keywords
- pyruvate oxidation, pigeon breast muscle, oxidative metabolism, pyruvate dehydrogenase, pyruvate dehydrogenase complex, acetate production, ketone bodies, muscle metabolism
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