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Cited by 205

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Inhibition of cytochrome systems of heart muscle and certain bacteria by the antagonists of dihydrostreptomycin: 2-alkyl-4-hydroxyquinoline N-oxides

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Lightbown, J. W., Jackson, F. L.·1956·Biochemical Journal
DOI 10.1042/bj0630130
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Abstract

Antagonism of streptomycin activity by culture filtrates of Pseudononas aerugino8a was first reported by Sureau, Arquie, Boyer & Saviard (1948).The factor responsible for the antagonism was isolated (Lightbown, 1954) and was shown by Cornforth & James (1954, 1956) to be a mixture of 2-alkyl-4-hydroxyquinoline N-oxides.The present paper describes an investigation of some of the biological properties of these compounds; part of this work has already been briefly reported (Lightbown & Jackson, 1954; Jackson & Light- bown, 1955). METHODS AND MATERIALS Assay of dihydrostreptomycin antagonist activity.A modified cup-plate diffusion method (Lightbown, 1954) was employed.Cups containing the solutions of the quino-

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Metadata

Authors
Lightbown, J. W., & Jackson, F. L.
Venue
Biochemical Journal
Publisher
Portland Press Ltd.
Published
1956-05-01
Volume
63
Issue
1
Pages
130-137
ISSN
0306-3283 (ISSN-L)
DOI
10.1042/bj0630130
OpenAlex
W345669585
Cited by
205
References
0
FWCI
9.05
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Inhibition of cytochrome systems of heart muscle and certain bacteria by the antagonists of dihydrostreptomycin: 2-alkyl-4-hydroxyquinoline N-oxides. https://app.cochat.ai/papers/10.1042/bj0630130
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Lightbown, J. W., & Jackson, F. L. (1956). Inhibition of cytochrome systems of heart muscle and certain bacteria by the antagonists of dihydrostreptomycin: 2-alkyl-4-hydroxyquinoline N-oxides. Biochemical Journal. https://doi.org/10.1042/bj0630130

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.