The metabolism of δ-aminolaevulic acid. 1. Normal pathways, studied with the aid of 15N
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On the basis of results obtained with in vitro systems, 6-aminolaevulic acid (ALA) has been found by several groups ofworkers to be a biological precursor of porphyrins and haem.The following reactions are believed to occur (Shemin & Russell, 1953; Neuberger & Scott, 1953
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The first report on excessive protoporphyrin accumulation and high photosensitivity after exogenous administration of ALA in humans was presented by Berlin et al. in 1956.
“The first report on excessive protoporphyrin accumulation and high photosensitivity after exogenous administration of ALA in humans was presented by Berlin et al. in 1956 [87].”
From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [87]
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References 19 · Cited by 126
- Authors
- Berlin, N. I., Neuberger, A., & Scott, J. J.
- Affiliations
- National Institute for Medical Research (GB)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1956-09-01
- Volume
- 64
- Issue
- 1
- Pages
- 80-90
- ISSN
- 0306-3283 (ISSN-L)
- PMC
- PMC1199693
- OpenAlex
- W2341799933
- Cited by
- 126
- References
- 19
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2019: 2 · 2018: 3 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 2
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Physical Sciences › Materials Science › Materials Chemistry › Porphyrin and Phthalocyanine Chemistry
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Keywords
- porphyrin synthesis, heme biosynthesis, 15N labeling, metabolic pathways
- MeSH terms
- Amino Acids
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