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Initial stages in the biosynthesis of porphyrins. 2. The formation of δ-aminolaevulic acid from glycine and succinyl-coenzyme A by particles from chicken erythrocytes
Open accessAbstract
It has been known for some time that the carbon skeleton of porphyrins can be synthesized in vivo entirely from glycine and a C4 compound which is an intermediate in the oxidative decarboxylation of oa-oxoglutarate to succinate (for review see Shemin, 1955).The discovery of the role of 8- aminolaevulic acid in porphyrin synthesis (Shemin & Russell, 1953; Neuberger & Scott, 1953; Dresel & Falk, 1953) led to the hypothesis that the initial reaction in porphyrin synthesis is the condensation of glycine with this C4 compound to form 8-amino- laevulic acid, which is then further metabolized to porphobilinogen and porphyrins.The correctness of this view was demonstrated in Part 1 (Laver, Neuberger & Udenfriend, 1958), which described the isolation and properties of a particulate system from erythrocytes of anaemic chickens that cat- alyses a net synthesis of 8-aminolaevulic acid from glycine and oc-oxoglutarate or succinate.
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Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product
Dailey, H. A., Dailey, T. A., Gerdes, S., Jahn, D., Jahn, M., O'Brian, M. R., & Warren, M. J. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00048-16 · Cited by 340
Mitochondrial Coproporphyrinogen Oxidase and Protoporphyrin Formation
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Metadata
- Authors
- Gibson, K. D., Laver, W. G., & Neuberger, A.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1958-09-01
- Volume
- 70
- Issue
- 1
- Pages
- 71-81
- ISSN
- 0306-3283 (ISSN-L)
- OpenAlex
- W2343629043
- Cited by
- 249
- References
- 0
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gibson, K. D., Laver, W. G., & Neuberger, A. (1958). Initial stages in the biosynthesis of porphyrins. 2. The formation of δ-aminolaevulic acid from glycine and succinyl-coenzyme A by particles from chicken erythrocytes. Biochemical Journal. https://doi.org/10.1042/bj0700071
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