The DOI matches its Crossref record.
INFLUENCE OF ETHANOL ON THE LIVER METABOLISM OF FED AND STARVED RATS
Open accessAbstract
1. The influence of ethanol on the metabolism of livers from fed and starved rats has been studied in liver-perfusion experiments. Results have been obtained on oxygen consumption and carbon dioxide production, on glucose release and uptake by the liver and on changes in the concentrations of lactate and pyruvate and of beta-hydroxybutyrate and acetoacetate in the perfusion medium. 2. Oxygen consumption and carbon dioxide production were lower in livers from starved rats than in livers from fed rats. Ethanol had no effect on the oxygen consumption of either type of liver. After the addition of ethanol to the perfusion medium carbon dioxide production ceased almost completely, the change being faster in livers from starved rats. 3. With livers from fed rats glucose was released from the liver into the perfusion medium. This release was slightly greater when ethanol was present. With livers from starved rats no release of glucose was observed, and when ethanol was added a marked uptake of glucose from the medium was found. A simultaneous release of glycolytic end products, lactate and pyruvate, into the medium occurred. 4. Acetate was the main metabolite accumulating in the perfusion medium when ethanol was oxidized. With livers from starved rats a slightly increased formation of ketone bodies was found when ethanol was present. 5. The lactate/pyruvate concentration ratio in the perfusion medium increased from 10 to 87 with livers from fed rats and from 20 to 171 with livers from starved rats when the livers were perfused with ethanol in the medium. The beta-hydroxybutyrate/acetoacetate concentration ratio increased from 0.8 to 7.6 with livers from fed rats and from 1.0 to 9.5 with livers from starved rats when ethanol was added to the medium. 6. The effects of ethanol are discussed and related to changes in the redox state of the liver that produce new conditions for some metabolic pathways.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Experimental cerebral ischemia in Mongolian gerbils: IV. Behaviour of biogenic amines
Mršulja, B. B., Mršulja, B. J., Spatz, M., Ito, U., Walker, J. T., & Klatzo, I. (1976) · Acta Neuropathologica · doi:10.1007/bf00685142 · Cited by 473
Exton, J. H. (1972) · Metabolism · doi:10.1016/0026-0495(72)90028-5 · Cited by 325
Metabolic Effects of Ethanol in Perfused Rat Liver
Williamson, J. R., Scholz, R., Browning, E. T., Thurman, R. G., & Fukami, M. H. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94307-3 · Cited by 321
Control of Gluconeogenesis in Liver
Exton, J. H., & Park, C. R. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93242-4 · Cited by 278
Rate control of the tricarboxylic acid cycle
Krebs, H. A. (1970) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(70)90028-2 · Cited by 196
Metadata
- Authors
- FROSANDER, O., RAEIHAE, N., SALASPURO, M., & MÄENPÄÄ, P.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1965-01-01
- Volume
- 94
- Issue
- 1
- Pages
- 259-265
- ISSN
- 0006-2936 (ISSN-L)
- OpenAlex
- W2253161376
- Cited by
- 193
- References
- 0
- FWCI
- 21.27
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: INFLUENCE OF ETHANOL ON THE LIVER METABOLISM OF FED AND STARVED RATS. https://app.cochat.ai/papers/10.1042/bj0940259
- The paper
- FROSANDER, O., RAEIHAE, N., SALASPURO, M., & MÄENPÄÄ, P. (1965). INFLUENCE OF ETHANOL ON THE LIVER METABOLISM OF FED AND STARVED RATS. Biochemical Journal. https://doi.org/10.1042/bj0940259
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
