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The species distribution of xanthine oxidase
Open accessAbstract
1. The distribution of xanthine oxidase in blood and tissues of various animals was studied by means of a radioactive assay capable of detecting 10(-7) unit of enzyme. The method was shown to be applicable to tissues with a high uricase content. 2. Of 16 mammalian species examined, six had low concentrations of xanthine oxidase in the serum. In six non-mammalian species, no activity was detected in the serum. 3. The enzyme was not found in the blood cells of any mammals, but was present in the nucleated red blood corpuscles of chicken, turtle and tortoise. 4. Studies of the tissue distribution in four species demonstrated high activities in the liver and intestinal mucosa and consistently low activities in skeletal muscle, heart and brain. 5. There is a rough correlation between the activity of enzyme in serum and its activity in lung tissue in 12 mammalian species. In the dog, left-atrial blood had higher concentrations of xanthine oxidase than right-atrial blood.
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Citations
Cited by
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Traystman, R. J., Kirsch, J. R., & Koehler, R. C. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.4.1185 · Cited by 653
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease
Aslan, M., Ryan, T. M., Adler, B., Townes, T. M., Parks, D. A., Thompson, J. A., Tousson, A., Gladwin, M. T., Patel, R. P., Tarpey, M. M., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221292098 · Cited by 391
Verbic, J., Chen, X. B., MacLeod, N. A., & Ørskov, E. R. (1990) · The Journal of Agricultural Science · doi:10.1017/s0021859600072610 · Cited by 373
Battelli, M. G., Bolognesi, A., & Polito, L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.022 · Cited by 256
“variation; in particular, a wide range of activity levels has been reported in biological fluids, such as blood [46] (reviewed in [47]) and milk (reviewed in [39]).”
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Bowman, G. L., Shannon, J., Frei, B., Kaye, J. A., & Quinn, J. F. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-1330 · Cited by 258
Metadata
- Authors
- Al-Khalidi, U., & Chaglassian, T.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1965-10-01
- Volume
- 97
- Issue
- 1
- Pages
- 318-320
- ISSN
- 0006-2936 (ISSN-L)
- OpenAlex
- W2248685074
- Cited by
- 271
- References
- 0
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Al-Khalidi, U., & Chaglassian, T. (1965). The species distribution of xanthine oxidase. Biochemical Journal. https://doi.org/10.1042/bj0970318
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
