The DOI matches its Crossref record.
An effect of insulin on adipose-tissue adenosine 3′:5′-cyclic monophosphate phosphodiesterase
Open accessAbstract
1. 3′:5′-Cyclic nucleotide phosphodiesterase activity was measured in homogenates prepared from epididymal fat-pads and isolated fat-cells incubated in the absence and presence of insulin. 2. Homogenates of insulin-treated tissues showed an increase in phosphodiesterase activity compared with controls. No effect of insulin was observed when the hormone was added directly to homogenates. 3. There was kinetic evidence for the presence of two 3′:5′-cyclic nucleotide phosphodiesterases in adipose tissue. Insulin raised the maximal velocity of the low-Km enzyme and lowered the Km of the higher-Km enzyme. 4. It is suggested that the effect of insulin on adipose tissue phosphodiesterase accounts for the ability of this hormone to lower cyclic-AMP concentration in the tissue.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions
Francis, S. H., Blount, M. A., & Corbin, J. D. (2011) · Physiological Reviews · doi:10.1152/physrev.00030.2010 · Cited by 639
Sasaki, K., Cripe, T. P., Koch, S. R., Andreone, T. L., Petersen, D. D., Beale, E. G., & Granner, D. K. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42541-5 · Cited by 428
Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones
Coore, H. G., Denton, R. M., Martin, B. R., & Randle, P. J. (1971) · Biochemical Journal · doi:10.1042/bj1250115 · Cited by 393
Role of calcium in the hormonal regulation of liver metabolism
Williamson, J. R., Cooper, R. H., & Hoek, J. B. (1981) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(81)90012-4 · Cited by 317
Cyclic Nucleotide-Dependent Protein Kinases: Intracellular Receptors for cAMP and cGMP Action
Francis, S. H., & Corbin, J. D. (1999) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408369991239213 · Cited by 305
Metadata
- Authors
- Loten, E. G., & Sneyd, J. G. T.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1970-11-01
- Volume
- 120
- Issue
- 1
- Pages
- 187-193
- ISSN
- 0306-3283 (ISSN-L)
- OpenAlex
- W23355599
- Cited by
- 346
- References
- 0
- FWCI
- 12.64
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: An effect of insulin on adipose-tissue adenosine 3′:5′-cyclic monophosphate phosphodiesterase. https://app.cochat.ai/papers/10.1042/bj1200187
- The paper
- Loten, E. G., & Sneyd, J. G. T. (1970). An effect of insulin on adipose-tissue adenosine 3′:5′-cyclic monophosphate phosphodiesterase. Biochemical Journal. https://doi.org/10.1042/bj1200187
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
