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Creatine kinase equilibrium and lactate content compared with muscle pH in tissue samples obtained after isometric exercise
Open accessAbstract
Muscle biopsies taken from the musculus quadriceps femoris of man were analysed for pH, ATP, ADP, AMP, creatine phosphate, creatine, lactate and pyruvate. Biopsies were taken at rest, after circulatory occlusion and after isometric contraction. Muscle pH decreased from 7.09 at rest to 6.56 after isometric exercise to fatigue. Decrease in muscle pH was linearly related to accumulation of lactate plus pyruvate. An increase of 22μmol of lactate plus pyruvate per g of muscle resulted in a fall of 0.5pH unit. The apparent equilibrium constant of the creatine kinase reaction (apparent KCK) increased after isometric contraction and a linear relationship between log(apparent KCK) and muscle pH was obtained. The low content of creatine phosphate in muscle after contraction as analysed from needle-biopsy samples is believed to be a consequence of an altered equilibrium state of the creatine kinase reaction. This in turn is attributed mainly to a change in intracellular pH.
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Citations
Cited by
Hochachka, P. W., & Mommsen, T. P. (1983) · Science · doi:10.1126/science.6298937 · Cited by 578
The time course of phosphorylcreatine resynthesis during recovery of the quadriceps muscle in man
Harris, R. C., Edwards, R. H. T., Hultman, E., Nordesj�, L. O., Nylind, B., & Sahlin, K. (1976) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/bf00585149 · Cited by 526
Self-citationRecovery of power output and muscle metabolites following 30 s of maximal sprint cycling in man
Bogdanis, G. C., Nevill, M. E., Boobis, L. H., Lakomy, H. K., & Nevill, A. M. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020533 · Cited by 431
Energetics of human muscle: Exercise‐induced ATP depletion
Taylor, D. J., Styles, P., Matthews, P. M., Arnold, D. A., Gadian, D. G., Bore, P., & Radda, G. K. (1986) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910030107 · Cited by 320
Influence of mitochondrial content on the sensitivity of respiratory control.
Dudley, G. A., Tullson, P. C., & Terjung, R. L. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48054-4 · Cited by 315
Metadata
- Authors
- Sahlin, K., Harris, R. C., & Hultman, E.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1975-11-15
- Volume
- 152
- Issue
- 2
- Pages
- 173-180
- ISSN
- 0306-3283 (ISSN-L)
- OpenAlex
- W1207714954
- Cited by
- 188
- References
- 0
- FWCI
- 10.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sahlin, K., Harris, R. C., & Hultman, E. (1975). Creatine kinase equilibrium and lactate content compared with muscle pH in tissue samples obtained after isometric exercise. Biochemical Journal. https://doi.org/10.1042/bj1520173
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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