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Inhibition of lysosomal α-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens
Open accessAbstract
An indolizidine alkaloid (swainsonine) was isolated from the plant Swainsona canescens. Swainsonine is a specific and potent inhibitor of alpha-mannosidase (EC 3.2.1.24) and when administered to animals produces a phenocopy of the genetically based lysosomal storage disease, mannosidosis. Evidence is presented to suggest that swainsonine is a reversible active site-directed inhibitor of lysosomal alpha-mannosidase.
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Citations
Cited by
INHIBITORS OF THE BIOSYNTHESIS AND PROCESSING OF N-LINKED OLIGOSACCHARIDE CHAINS
Elbein, A. D. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.002433 · Cited by 1,122
Trafficking of lysosomal enzymes in normal and disease states.
Kornfeld, S. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112262 · Cited by 451
Hamaguchi, J., Nakagawa, H., Takahashi, M., Kudo, T., Kamiyama, N., Sun, B., Oshima, T., Sato, Y., Deguchi, K., Todo, S., et al. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-58 · Cited by 45
Metadata
- Authors
- Dorling, P. R., Huxtable, C. R., & Colegate, S. M.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1980-11-01
- Volume
- 191
- Issue
- 2
- Pages
- 649-651
- ISSN
- 0264-6021 (ISSN-L)
- OpenAlex
- W57809147
- Cited by
- 372
- References
- 0
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Inhibition of lysosomal α-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens. https://app.cochat.ai/papers/10.1042/bj1910649
- The paper
- Dorling, P. R., Huxtable, C. R., & Colegate, S. M. (1980). Inhibition of lysosomal α-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens. Biochemical Journal. https://doi.org/10.1042/bj1910649
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
