Principles of interleukin (IL)-6-type cytokine signalling and its regulation

Cites (265)

Items 201–269 of 269

1. Non-redundant Signal Transduction of Interleukin-6-type Cytokines
   Heike M. Hermanns, Simone Radtke, Fred Schaper, Peter Claus Heinrich, Iris Behrmann · 2000 · Journal of Biological Chemistry
2. Stat5b Inhibits NFκB-Mediated Signaling
   Guoyang Luo, Li‐Yuan Yu‐Lee · 2000 · Molecular Endocrinology
3. Identification of the promoter sequences involved in the interleukin-6 dependent expression of the rat α2-macroglobulin gene
   Dieter Kunz, René Zimmermann, Michael Heisig, Peter Claus Heinrich · 1989 · Nucleic Acids Research
4. Stat5a Serine Phosphorylation
   Iwan Beuvink, Daniel Heß, Horst Flotow · 2000 · Journal of Biological Chemistry
5. Stat5B Shuttles Between Cytoplasm and Nucleus in a Cytokine-Dependent and -Independent Manner
   Rong Zeng, Yutaka Aoki, Minoru Yoshida, Ken‐ichi Arai, Sumiko Watanabe · 2002 · The Journal of Immunology
6. Regulation of STAT1 Nuclear Export by Jak1
   Kerri A. Mowen, Michael David · 2000 · Molecular and Cellular Biology
7. Analysis of the Life Cycle of Stat6
   Ryan P. Andrews, Mark B. Ericksen, Christie M. Cunningham, Michael Daines, Gurjit K. Khurana Hershey · 2002 · Journal of Biological Chemistry
8. Receptor Subunit-specific Action of Oncostatin M in Hepatic Cells and Its Modulation by Leukemia Inhibitory Factor*
   Y. Wang, O. Robledo, E. Kinzie, F. Blanchard, C. Richards, A. Miyajima, H. Baumann · 2000 · Journal of Biological Chemistry
9. Akt Modulates STAT3-mediated Gene Expression through a FKHR (FOXO1a)-dependent Mechanism
   Marcin Kortylewski, Florian Feld, Klaus-Dieter Krüger, Gregor Bahrenberg, Richard A. Roth, Hans‐Georg Joost, Peter Claus Heinrich, Iris Behrmann, Andreas Barthel · 2003 · Journal of Biological Chemistry
10. A Mutant Form of JAB/SOCS1 Augments the Cytokine-induced JAK/STAT Pathway by Accelerating Degradation of Wild-type JAB/CIS Family Proteins through the SOCS-box
    Toshikatsu Hanada, Takafumi Yoshida, Ichiko Kinjyo, Shigeru Minoguchi, Hideo Yasukawa, Seiya Kato, Hiromitsu Mimata, Yoshio Nomura, Youichi Seki, Masato Kubo et al. · 2001 · Journal of Biological Chemistry
11. Contributions of Leukemia Inhibitory Factor Receptor and Oncostatin M Receptor to Signal Transduction in Heterodimeric Complexes with Glycoprotein 130
    Hermanns, Heike M, Radtke, Simone, Haan, Claude, Schmitz-Van de Leur, Hildegard, Tavernier, Jan, Heinrich, Peter C, Behrmann, Iris · 1999 · The Journal of Immunology
12. Crystal structure and functional dissection of the cytostatic cytokine oncostatin M
    Marc C. Deller, Keith Hudson, Shinji Ikemizu, Jerónimo Bravo, E. Yvonne Jones, John K. Heath · 2000 · Structure
13. Evidence for a crucial role of neutrophil‐derived serine proteases in the inactivation of interleukin‐6 at sites of inflammation
    Ute Bank, Bernadette Küpper, Dirk Reinhold · 1999 · FEBS Letters
14. The MKK6/p38 Mitogen-Activated Protein Kinase Pathway Is Capable of Inducing SOCS3 Gene Expression and Inhibits IL-6-Induced Transcription
    Johannes Georg Bode, Stephan Ludwig, C.A. Correia Freitas, Fred Schaper, M. Ruhl, Shlomo K. Melmed, Peter Claus Heinrich, Dieter Häussinger · 2001 · Biological Chemistry
15. Mapping of a Region within the N Terminus of Jak1 Involved in Cytokine Receptor Interaction
    Claude Haan, Hayaatun Is’harc, Heike M. Hermanns, Hildegard Schmitz-Van de Leur, Ian Macpherson Kerr, Peter Claus Heinrich, Joachim Grötzinger, Iris Behrmann · 2001 · Journal of Biological Chemistry
16. Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation.
    C. Haan, P. Heinrich, I. Behrmann · 2002 · Biochemical Journal
17. Stimulation of Leukemia Inhibitory Factor Receptor Degradation by Extracellular Signal-regulated Kinase
    Frédéric Blanchard, Laurence Duplomb, Yanping Wang, Olivier Robledo, Erin Kinzie, Vincent Pitard, Anne Godard, Yannick Jacques, Heinz Baumann · 2000 · Journal of Biological Chemistry
18. Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes.
    Yang Wang, G. Fuller · 1994 · Molecular Biology of the Cell
19. The Immunoglobulin-like Module of gp130 Is Required for Signaling by Interleukin-6, but Not by Leukemia Inhibitory Factor
    Annet Hammacher, Rachael T. Richardson, Judith E. Layton · 1998 · Journal of Biological Chemistry
20. The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway
    Abe, Koji, Hirai, Manabu, Mizuno, Katsunori, Higashi, Natsuko, Sekimoto, Toshihiro, Miki, Tokuhiko, Hirano, Toshio, Nakajima, Koichi · 2001 · Oncogene
21. Protein Kinase C δ Associates with the Interleukin-6 Receptor Subunit Glycoprotein (gp) 130 via Stat3 and Enhances Stat3-gp130 Interaction*
    V. Novotny-Diermayr, Tong Zhang, L. Gu, X. Cao · 2002 · Journal of Biological Chemistry
22. Protein tyrosine phosphatase epsilonC selectively inhibits interleukin-6- and interleukin- 10-induced JAK-STAT signaling.
    N. Tanuma, H. Shima, Koji Nakamura, K. Kikuchi · 2001 · Blood
23. Influence of Subunit Combinations on Signaling by Receptors for Oncostatin M, Leukemia Inhibitory Factor, and Interleukin-6*
    Karen K. Kuropatwinski, C. De Imus, D. Gearing, H. Baumann, B. Mosley · 1997 · Journal of Biological Chemistry
24. Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation
    Claude Haan, Peter Claus Heinrich, Iris Behrmann · 2002 · Biochemical Journal
25. STAT3 Forms Stable Homodimers in the Presence of Divalent Cations Prior to Activation
    Ulrike Novak, Hong Ji, Varuni Kanagasundaram, Richard J. Simpson, Lucy Paradiso · 1998 · Biochemical and Biophysical Research Communications
26. Cloning and Characterization of Gu/RH-II Binding Protein
    Benigno C. Valdez, Dale Henning, László Perlaky · 1997 · Biochemical and Biophysical Research Communications
27. Separate Signaling Mechanisms Are Involved in the Control of STAT Protein Activation and Gene Regulation via the Interleukin 6 Response Element by the Box 3 Motif of gp130 (*)
    C. Lai, J. Ripperger, K. K. Morella, Y. Wang, D. Gearing, G. Fey, H. Baumann · 1995 · Journal of Biological Chemistry
28. Signaling through a Novel Domain of gp130 Mediates Cell Proliferation and Activation of Hck and Erk Kinases
    Michael Schaeffer, Michaela Maria Schneiderbauer, Sascha Weidler, Rosário Tavares, Markus Warmuth, Gabriele de Vos, Michael J. Hallek · 2001 · Molecular and Cellular Biology
29. Modulation of hepatic acute phase gene expression by epidermal growth factor and src protein tyrosine kinases in murine and human hepatic cells
    Yanping Wang, Jürgen A. Ripperger, Georg H. Fey, David R. Samols, Tomek Kordula, Meir Wetzler, Richard A. Van Etten, Heinz Baumann · 1999 · Hepatology
30. Characterization and Binding Specificity of the Monomeric STAT3-SH2 Domain*
    S. Haan, U. Hemmann, U. Hassiepen, F. Schaper, J. Schneider-Mergener, A. Wollmer, P. Heinrich, J. Grötzinger · 1999 · Journal of Biological Chemistry
31. Integration of Jak-Stat and AP-1 Signaling Pathways at the Vasoactive Intestinal Peptide Cytokine Response Element Regulates Ciliary Neurotrophic Factor-dependent Transcription*
    A. Symes, T. Gearan, J. Eby, J. Fink · 1997 · Journal of Biological Chemistry
32. Orientational Constraints of the gp130 Intracellular Juxtamembrane Domain for Signaling
    Jens Steffen Greiser, Claudia Stroß, Peter Claus Heinrich, Iris Behrmann, Heike M. Hermanns · 2002 · Journal of Biological Chemistry
33. The Competitive Binding of STAT3 and NF-κB on an Overlapping DNA Binding Site
    Zhixin Zhang, Gerald M. Fuller · 1997 · Biochemical and Biophysical Research Communications
34. Biosynthesis and half-life of the interleukin-6 receptor and its signal transducer gp130.
    C. Gerhartz, E. Dittrich, T. Stoyan, S. Rose-John, Kiyoshi Yasukawa, P. C. Heinrich, L. Graeve · 1994 · European Journal of Biochemistry
35. The phosphotidyl inositol 3-kinase/Akt signal pathway is involved in interleukin-6-mediated Mcl-1 upregulation and anti-apoptosis activity in basal cell carcinoma cells.
    S. Jee, H.-C. Chiu, T. Tsai, Wei-Ling Tsai, Yi-Hua Liao, Chia-Yu Chu, Ming-Liang Kuo · 2002 · Journal of Investigative Dermatology
36. Signal Transduction of IL-6, Leukemia-Inhibitory Factor, and Oncostatin M: Structural Receptor Requirements for Signal Attenuation
    Dirk Anhuf, Manuela Weißenbach, Jochen Schmitz, Radoslaw Mikolaj Sobota, Heike M. Hermanns, Simone Radtke, Sonja Linnemann, Iris Behrmann, Peter Claus Heinrich, Fred Schaper · 2000 · The Journal of Immunology
37. An Acute Phase Response Factor/NF-κB Site Downstream of the junB Gene That Mediates Responsiveness to Interleukin-6 in a Murine Plasmacytoma
    Robert T. Brown, Ibrahim Z. Ades, Richard P. Nordan · 1995 · Journal of Biological Chemistry
38. A functional role of the membrane‐proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor
    Andreas Timmermann, Andrea Küster, Ingo Kurth, Peter Claus Heinrich, Gerhard Müller‐Newen · 2002 · European Journal of Biochemistry
39. Constitutive internalization and association with adaptor protein‐2 of the interleukin‐6 signal transducer gp130
    Stefanie Thiel, Heike Dahmen, Astrid S. Martens, G. Müller-Newen, F. Schaper, Peter C. Heinrich, L. Graeve · 1998 · FEBS Letters
40. Human herpes virus 8 interleukin‐6 homologue triggers gp130 on neuronal and hematopoietic cells
    Susanne H. Hoischen, Petra Vollmer, Pia März, Suat Özbek, Katharina S. S. Götze, Christian Peschel, Thomas Jostock, Till Geib, Jürgen Müllberg, Sabine Mechtersheimer et al. · 2000 · European Journal of Biochemistry
41. Interleukin 1β inhibits interleukin 6–mediated rat γ fibrinogen gene expression
    Zhixin Zhang, Gerald M. Fuller · 2000 · Blood
42. Design of Conditionally Active STATs: Insights into STAT Activation and Gene Regulatory Function
    Milocco, Lawrence H., Haslam, Jennifer A., Rosen, Jonathan, Seidel, H. Martin · 1999 · Molecular and Cellular Biology
43. The Inhibitory Effect of IL-1β on IL-6-Induced α2-Macroglobulin Expression Is Due to Activation of NF-κB
    Johannes Georg Bode, Richard Fischer, Dieter Häussinger, Lutz Graeve, Peter Claus Heinrich, Fred Schaper · 2001 · The Journal of Immunology
44. The role of Stat and C/EBP transcription factors in the synergistic activation of rat serine protease inhibitor-3 gene by interleukin-6 and dexamethasone
    Tomasz Kordula, James W. Travis · 1996 · Biochemical Journal
45. Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3)
    Florence Magrangeas, Olivier Boisteau, Sébastien DENIS, Yannick Jacques, Stéphane Minvielle · 2001 · Biochemical Journal
46. Phosphorylation of Human gp130 at Ser-782 Adjacent to the Di-leucine Internalization Motif
    Robin M. Gibson, William P. Schiemann, Lisa B. Prichard, John M. Reno, Lowell H. Ericsson, Neil M. Nathanson · 2000 · Journal of Biological Chemistry
47. Studies on the Interleukin-6-type Cytokine Signal Transducer gp130 Reveal a Novel Mechanism of Receptor Activation by Monoclonal Antibodies*
    G. Müller-Newen, Andrea Küster, J. Wijdenes, F. Schaper, P. Heinrich · 2000 · Journal of Biological Chemistry
48. The Unusual Species Cross-reactivity of the Leukemia Inhibitory Factor Receptor α-Chain Is Determined Primarily by the Immunoglobulin-like Domain
    Catherine M. Owczarek, Yu Long Zhang, Meredith J. Layton · 1997 · Journal of Biological Chemistry
49. Insulin Is a Prominent Modulator of the Cytokine-Stimulated Expression of Acute-Phase Plasma Protein Genes
    Susana P. Campos, Heinz Baumann · 1992 · Molecular and Cellular Biology
50. Induction of Apoptosis by Protein Inhibitor of Activated Stat1 through c-Jun NH2-terminal Kinase Activation
    Bin Liu, Ke Shuai · 2001 · Journal of Biological Chemistry
51. Two Different Epitopes of the Signal Transducer gp130 Sequentially Cooperate on IL-6-Induced Receptor Activation1
    S. Pflanz, I. Kurth, J. Grötzinger, P. Heinrich, G. Müller-Newen · 2000 · Journal of Immunology
52. Will any dimer do?
    Marcus D. Ballinger, James A. Wells · 1998 · Nature Structural Biology
53. Cytoplasmic Domains of the Leukemia Inhibitory Factor Receptor Required for STAT3 Activation, Differentiation, and Growth Arrest of Myeloid Leukemic Cells
    Mikio Tomida, Toshio Heike, Takashi Yokota · 1999 · Blood
54. A Rhesus Macaque Rhadinovirus Related to Kaposi’s Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 Encodes a Functional Homologue of Interleukin-6
    Johnan A.R. Kaleeba, Eric P. Bergquam, Scott W. Wong · 1999 · Journal of Virology
55. Involvement of Tyrosine Phosphatase PTP1D in the Inhibition of Interleukin-6-Induced Stat3 Signaling by α-Thrombin
    Jagadambika J. Gunaje, G. Jayarama Bhat · 2001 · Biochemical and Biophysical Research Communications
56. The cytoplasmic domain of the interleukin-6 receptor gp80 mediates its basolateral sorting in polarized Madin-Darby canine kidney cells
    Astrid S. Martens, Johannes Georg Bode, Peter Claus Heinrich, Lutz Graeve · 2000 · Journal of Cell Science
57. A completely foreign receptor can mediate an interferon‐γ‐like response
    Birgit Strobl, Velmurugesan Arulampalam, Hayaatun Is'harc, Sally J. Newman, Jörg F. Schlaak, Diane Watling, Ana P. Costa‐Pereira, Fred Schaper, Iris Behrmann, Kathleen C.F. Sheehan et al. · 2001 · The EMBO Journal
58. Different epitopes are required for gp130 activation by interleukin‐6, oncostatin M and leukemia inhibitory factor
    A. Timmermann, S. Pflanz, J. Grötzinger, Andrea Küster, I. Kurth, V. Pitard, P. C. Heinrich, G. Müller-Newen · 2000 · FEBS Letters
59. Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors
    Annet Hammacher, John Wijdenes, Douglas J. Hilton · 1999 · Biochemical Journal
60. A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3
    Koh Nakayama, Kyung‐Woon Kim, Atsushi Miyajima · 2002 · The EMBO Journal
61. Identification of a Leu-Ile internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor
    Stefan Thiel, Iris Behrmann, Andreas Timmermann, Heike Dahmen, Gerhard Müller‐Newen, Fred Schaper, Jan Tavernier, Vincent Pitard, Peter Claus Heinrich, Lutz Graeve · 1999 · Biochemical Journal
62. Cdk9, a member of the cdc2-like family of kinases, binds to gp130, the receptor of the IL-6 family of cytokines
    Giulia De Falco, Luca Maria Neri, Maria De Falco, Cristiana Bellan, Zailin Yu, Antonio De Luca, Lorenzo Leoncini, Antonio Giordano · 2002 · Oncogene
63. A single amino acid substitution (Trp666→Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction
    Claude Haan, Heike M. Hermanns, Peter Claus Heinrich, Iris Behrmann · 2000 · Biochemical Journal
64. Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3)
    Florence Magrangeas, Olivier Boisteau, Sébastien DENIS · 2001 · Biochemical Journal
65. Dimerization and activation of the common transducing chain (gp130) of the cytokines of the IL-6 family by mAb.
    Patrick Autissier, John De Vos, Janny Liautard · 1998 · International Immunology
66. Receptor recognition by gp130 cytokines
    John K. Heath, Keith Hudson, Jerónimo Bravo · 2000 · Biochemical Society Transactions
67. Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors
    Annet Hammacher, John Wijdenes, Douglas J. Hilton · 2000 · Biochemical Journal
68. Identification of a Leu-Ile internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor
    Stefan THIEL, Iris BEHRMANN, Andreas TIMMERMANN, Heike DAHMEN, Gerhard MÜLLER-NEWEN, Fred SCHAPER, Jan TAVERNIER, Vincent PITARD, Peter C. HEINRICH, Lutz GRAEVE · 1999 · Biochemical Journal
69. A single amino acid substitution (Trp666→Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction
    Claude HAAN, Heike M. HERMANNS, Peter C. HEINRICH, Iris BEHRMANN · 2000 · Biochemical Journal