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Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide
Abstract
H2S (hydrogen sulfide) has recently been recognized as a signalling molecule as well as a cytoprotectant. We recently demonstrated that 3MST (3-mercaptopyruvate sulfurtransferase) produces H2S from 3MP (3-mercaptopyruvate). Although a reducing substance is required for an intermediate persulfide at the active site of 3MST to release H2S, the substance has not been identified. In the present study we show that Trx (thioredoxin) and DHLA (dihydrolipoic acid) associate with 3MST to release H2S. Other reducing substances, such as NADPH, NADH, GSH, cysteine and CoA, did not have any effect on the reaction. We also show that 3MST produces H2S from thiosulfate. The present study provides a new insight into a mechanism for the production of H2S by 3MST.
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Citations
Cited by
Chemical Biology of H2S Signaling through Persulfidation
Filipovic, M. R., Zivanovic, J., Alvarez, B., & Banerjee, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00205 · Cited by 1,046
A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells
Shibuya, N., Koike, S., Tanaka, M., Ishigami-Yuasa, M., Kimura, Y., Ogasawara, Y., Fukui, K., Nagahara, N., & Kimura, H. (2013) · Nature Communications · doi:10.1038/ncomms2371 · Cited by 558
Self-citationPhysiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Cirino, G., Szabo, C., & Papapetropoulos, A. (2023) · Physiological Reviews · doi:10.1152/physrev.00028.2021 · Cited by 553
Pedre, B., Barayeu, U., Ezeriņa, D., & Dick, T. P. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107916 · Cited by 470
Szabo, C., Ransy, C., Módis, K., Andriamihaja, M., Murghes, B., Coletta, C., Olah, G., Yanagi, K., & Bouillaud, F. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12369 · Cited by 440
Metadata
- Authors
- Mikami, Y., Shibuya, N., Kimura, Y., Nagahara, N., Ogasawara, Y., & Kimura, H.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2011-10-13
- Volume
- 439
- Issue
- 3
- Pages
- 479-485
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2038600558
- Cited by
- 294
- References
- 0
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mikami, Y., Shibuya, N., Kimura, Y., Nagahara, N., Ogasawara, Y., & Kimura, H. (2011). Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide. Biochemical Journal. https://doi.org/10.1042/bj20110841
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