Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling.

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062

Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide

Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

Nitric Oxide and Peroxynitrite in Health and Disease

Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026

Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease

Zhang, J., Culp, M. L., Craver, J., & Darley-Usmar, V. M. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14308 · Cited by 74

Mitochondrial dependency in progression of acute myeloid leukemia

Basak, N. P., & Banerjee, S. (2015) · Mitochondrion · doi:10.1016/j.mito.2015.01.006 · Cited by 75

Exposure of Monocytic Cells to Lipopolysaccharide Induces Coordinated Endotoxin Tolerance, Mitochondrial Biogenesis, Mitophagy, and Antioxidant Defenses

Widdrington, J. D., Gómez-Durán, A., Pyle, A., Ruchaud‐Sparagano, M., Scott, J., Baudouin, S., Rostron, A., Lovat, P. E., Chinnery, P. F., & Simpson, A. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02217 · Cited by 72

A multitude of signaling pathways associated with Alzheimer's disease and their roles in AD pathogenesis and therapy

Gadhave, K., Kumar, D., Uversky, V. N., & Giri, R. (2020) · Medicinal Research Reviews · doi:10.1002/med.21719 · Cited by 71

Autophagy: an emerging therapeutic target in vascular diseases

Vindis, C. (2014) · British Journal of Pharmacology · doi:10.1111/bph.13052 · Cited by 75

GOLPH3 Mediated Golgi Stress Response in Modulating N2A Cell Death upon Oxygen-Glucose Deprivation and Reoxygenation Injury

Li, T., You, H., Mo, X., He, W., Tang, X., Jiang, Z., Chen, S., Chen, Y., Zhang, J., & Hu, Z. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-9083-0 · Cited by 72

Doxorubicin-induced markers of myocardial autophagic signaling in sedentary and exercise trained animals

Smuder, A. J., Kavazis, A. N., Min, K., & Powers, S. K. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00924.2012 · Cited by 76

Flavonoid Fraction of Orange and Bergamot Juices Protect Human Lung Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Stress

Ferlazzo, N., Visalli, G., Smeriglio, A., Cirmi, S., Lombardo, G. E., Campiglia, P., Pietro, A. D., & Navarra, M. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/957031 · Cited by 71

Is ftsH the Key to Plastid Longevity in Sacoglossan Slugs?

de Vries, J., Habicht, J., Woehle, C., Huang, C., Christa, G., Wägele, H., Nickelsen, J., Martin, W., & Gould, S. (2013) · Genome Biology and Evolution · doi:10.1093/gbe/evt205 · Cited by 73

Lithium protects dopaminergic cells from rotenone toxicity via autophagy enhancement

Hou, L., Xiong, N., Liu, L., Huang, J., Han, C., Zhang, G., Li, J., Xu, X., Lin, Z., & Wang, T. (2015) · BMC Neuroscience · doi:10.1186/s12868-015-0222-y · Cited by 71

Paternal exposure to arsenic resulted in oxidative stress, autophagy, and mitochondrial impairments in the HPG axis of pubertal male offspring

Ommati, M. M., Heidari, R., Manthari, R. K., Chiranjeevi, S. T., Niu, R., Sun, Z., Sabouri, S., Zamiri, M. J., Zaker, L., Yuan, J., et al. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.07.056 · Cited by 71

Insights into the Role of Oxidative Stress in Ovarian Cancer

Ding, D., Xie, L., Shen, Y., Li, J., Guo, Y., Fu, Y., Liu, F.-Y., & Han, F. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8388258 · Cited by 74

Mitochondrial Dysfunction and Oxidative Stress Promote Apoptotic Cell Death in the Striatum via Cytochrome c/ Caspase-3 Signaling Cascade Following Chronic Rotenone Intoxication in Rats

Lin, T., Cheng, C.-H., Chen, S., Liou, C., Huang, C., & Chuang, Y. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13078722 · Cited by 71

Thioredoxin-interacting protein mediates dysfunction of tubular autophagy in diabetic kidneys through inhibiting autophagic flux

Huang, C., Lin, M. Z., Cheng, D., Braet, F., Pollock, C. A., & Chen, X. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.2 · Cited by 71

Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation

Zhang, Y., Liu, G., Dull, R. O., Schwartz, D. E., & Hu, H. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00083.2014 · Cited by 71

Effects of methionine supplementation on the expression of oxidative stress-related genes in acute heat stress-exposed broilers

Vesco, A. P. D., Gasparino, E., Grieser, D. D. O., Zancanela, V. T., Soares, M. A. M., & Neto, A. R. D. O. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514003535 · Cited by 71

Redox regulation of autophagy in skeletal muscle

Rodney, G. G., Pal, R., & Abo‐Zahrah, R. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.05.010 · Cited by 75

Lipopolysaccharide from Porphyromonas gingivalis promotes autophagy of human gingival fibroblasts through the PI3K/Akt/mTOR signaling pathway

Liu, J., Wang, X., Zheng, M., & Luan, Q. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.09.023 · Cited by 71

Bisphenol a induces autophagy and apoptosis concurrently involving the Akt/mTOR pathway in testes of pubertal SD rats

Quan, C., Wang, C., Duan, P., Huang, W., Chen, W., Tang, S., & Yang, K. (2016) · Environmental Toxicology · doi:10.1002/tox.22339 · Cited by 73

Selenizing astragalus polysaccharide attenuates PCV2 replication promotion caused by oxidative stress through autophagy inhibition via PI3K/AKT activation

Liu, D., Xu, J., Qian, G., Hamid, M., Gan, F., Chen, X., & Huang, K. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.12.010 · Cited by 70

Sjøgren's syndrome-associated oxidative stress and mitochondrial dysfunction: Prospects for chemoprevention trials

Pagano, G., Castello, G., & Pallardó, F. V. (2012) · Free Radical Research · doi:10.3109/10715762.2012.748904 · Cited by 69

Pancreatic β Cell Mass Death

Marrif, H. I., & Alsunousi, S. I. A. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00083 · Cited by 72

Aldehyde dehydrogenase 2 activation ameliorates CC l4‐induced chronic liver fibrosis in mice by up‐regulating Nrf2/ HO ‐1 antioxidant pathway

Ma, X., Luo, Q., Zhu, H., Liu, X., Dong, Z., Zhang, K., Zou, Y., Wu, J., Ge, J., & Sun, A. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13677 · Cited by 69

Autophagy Dysfunction and Oxidative Stress, Two Related Mechanisms Implicated in Retinitis Pigmentosa

Moreno, M. L., Mérida, S., Bosch‐Morell, F., Miranda, M., & Villar, V. M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01008 · Cited by 69

Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype

Hommel, B., Sturny-Leclère, A., Volant, S., Veluppillai, N., Duchateau, M., Yu, C.-H. A., Hourdel, V., Varet, H., Matondo, M., Perfect, J. R., et al. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007945 · Cited by 66

Oxidative Stress and Redox Signaling in the Pathophysiology of Liver Diseases

Mooli, R. G. R., Mukhi, D., & Ramakrishnan, S. K. (2022) · Comprehensive physiology · doi:10.1002/cphy.c200021 · Cited by 134

The Homozygote VCPR155H/R155H Mouse Model Exhibits Accelerated Human VCP-Associated Disease Pathology

Nalbandian, A., Llewellyn, K. J., Kitazawa, M., Yin, H. Z., Badadani, M., Khanlou, N., Edwards, R., Nguyen, C., Mukherjee, J., Mozaffar, T., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046308 · Cited by 68

Ovarian mitochondrial dynamics and cell fate regulation in an androgen-induced rat model of polycystic ovarian syndrome

Salehi, R., Mazier, H. L., Nivet, A., Reunov, A., Lima, P., Wang, Q., Fiocco, A., Isidoro, C., & Tsang, B. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-57672-w · Cited by 68

Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome

Toro-Pérez, J., & Rodrigo, R. (2021) · Redox Report · doi:10.1080/13510002.2021.1891808 · Cited by 68

Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes

McKee, C. A., Polino, A. J., King, M. W., & Musiek, E. S. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2220551120 · Cited by 70

Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis

Richard, V. R., Leonov, A., Beach, A., Burstein, M. T., Koupaki, O., Gomez-Perez, A., Levy, S., Pluska, L., Mattie, S., Rafeh, R., et al. (2013) · Aging · doi:10.18632/aging.100547 · Cited by 69

NADPH oxidase activation is required for pentylenetetrazole kindling-induced hippocampal autophagy

Zhu, X., Shen, K., Bai, Y., Zhang, A., Xia, Z., Chao, J., & Yao, H. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.03.004 · Cited by 68

Ameliorating mitochondrial dysfunction restores carbon ion-induced cognitive deficits via co-activation of NRF2 and PINK1 signaling pathway

Liu, Y., Yan, J., Sun, C., Guo, L., Li, S., Zhang, L., Di, C., Gan, L., Wang, Y., Zhou, R., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.04.012 · Cited by 68

Beneficial effects of astragaloside IV against angiotensin II-induced mitochondrial dysfunction in rat vascular smooth muscle cells

Lu, Y., Su, L., Wu, H., Bian, Z., Xu, J.-D., Gu, C., Chen, X., & Yang, D. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2345 · Cited by 67

The dual role of poly(ADP-ribose) polymerase-1 in modulating parthanatos and autophagy under oxidative stress in rat cochlear marginal cells of the stria vascularis

Jiang, H., Yang, Y., Zhang, Y., Xie, Z., Zhao, X., Sun, Y., & Kong, W. (2017) · Redox Biology · doi:10.1016/j.redox.2017.10.002 · Cited by 69

Inhibition of Mitochondrial Complex Function—The Hepatotoxicity Mechanism of Emodin Based on Quantitative Proteomic Analyses

Lin, L., Liu, Y., Fu, S., Qu, C., Li, H., & Ni, J. (2019) · Cells · doi:10.3390/cells8030263 · Cited by 67

Sustained Activation of Akt Elicits Mitochondrial Dysfunction to Block Plasmodium falciparum Infection in the Mosquito Host

Luckhart, S., Giulivi, C., Drexler, A., Antonova‐Koch, Y., Sakaguchi, D., Napoli, E., Wong, S., Price, M. S., Eigenheer, R. A., Phinney, B. S., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003180 · Cited by 68

Catalase Therapy Corrects Oxidative Stress-Induced Pathophysiology in Incipient Diabetic Retinopathy

Giordano, C. R., Roberts, R. A., Krentz, K. A., Bissig, D., Talreja, D., Kumar, A., Terlecky, S. R., & Berkowitz, B. A. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-16194 · Cited by 68

Effects of atrazine and chlorpyrifos on oxidative stress-induced autophagy in the immune organs of common carp (Cyprinus carpio L.)

Chen, D., Zhang, Z., Yao, H., Liang, Y., Xing, H., & Xu, S. (2015) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2015.01.014 · Cited by 66

Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism

Wende, A. R., Young, M. E., Chatham, J. C., Zhang, J., Rajasekaran, N. S., & Darley-Usmar, V. M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.05.022 · Cited by 66

Exercise modulates liver cellular and mitochondrial proteins related to quality control signaling

Alves, E. S., Marques‐Aleixo, I., Rizo‐Roca, D., Torrella, J. R., Oliveira, P. J., Magalhães, J., & Ascensão, A. A. M. R. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.06.007 · Cited by 65

Atg9b Deficiency Suppresses Autophagy and Potentiates Endoplasmic Reticulum Stress-Associated Hepatocyte Apoptosis in Hepatocarcinogenesis

Wang, N., Tan, H., Li, S., & Feng, Y. (2017) · Theranostics · doi:10.7150/thno.18225 · Cited by 65

Liquiritin suppresses UVB‑induced skin injury through prevention of inflammation, oxidative stress and apoptosis through the TLR4/MyD88/NF‑κB and MAPK/caspase signaling pathways

Li, X., Cai, L., Liu, J., Ma, Y., Kong, Y., He, L., & Jiang, M. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3720 · Cited by 65

Protective Effects of Salidroside against Carbon Tetrachloride (CCl4)-Induced Liver Injury by Initiating Mitochondria to Resist Oxidative Stress in Mice

Lin, S., Xu, D., Du, X., Ran, C., Lu, X., Ren, S.-J., Tang, Z., Yin, L., He, C.-L., Yuan, Z., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133187 · Cited by 65

Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress

Gonzalez, Y., Aryal, B., Chehab, L., & Rao, V. A. (2014) · Oncotarget · doi:10.18632/oncotarget.1715 · Cited by 60

For whom the bell tolls: Distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases

Manolagas, S. C., & PARFITT, A. M. (2012) · Bone · doi:10.1016/j.bone.2012.09.017 · Cited by 65

Placental autophagy regulation by the BOK-MCL1 rheostat

Kalkat, M., Garcia, J., Ebrahimi, J., Melland‐Smith, M., Todros, T., Post, M., & Caniggia, I. (2013) · Autophagy · doi:10.4161/auto.26452 · Cited by 65

Modulation of oxidative stress, inflammation, autophagy and expression of Nrf2 in hippocampus and frontal cortex of rats fed with açaí-enriched diets

Poulose, S. M., Bielinski, D. F., Carey, A. N., Schauss, A. G., & Shukitt‐Hale, B. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2015.1125654 · Cited by 64

Bioenergetics and translational metabolism: implications for genetics, physiology and precision medicine

Hill, B. G., Shiva, S., Ballinger, S. W., Zhang, J., & Darley-Usmar, V. M. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0268 · Cited by 66

Effects of probiotic Bacillus as a substitute for antibiotics on antioxidant capacity and intestinal autophagy of piglets

Wang, Y., Wu, Y., Wang, B., Cao, X., Fu, A., Li, Y., & Li, W. (2017) · AMB Express · doi:10.1186/s13568-017-0353-x · Cited by 63

Enhanced autophagy contributes to protective effects of IL-22 against acetaminophen-induced liver injury

Mo, R., Lai, R., Lu, J. L., Zhuang, Y., Zhou, T., Jiang, S., Ren, P., Li, Z., Cao, Z., Liu, Y., et al. (2018) · Theranostics · doi:10.7150/thno.25798 · Cited by 62

Nuclear Factor-kappaB-Dependent Sestrin2 Induction Mediates the Antioxidant Effects of BDNF Against Mitochondrial Inhibition in Rat Cortical Neurons

Wu, C., Chen, S., Yin, J., Hwang, C., & Yang, D. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9357-1 · Cited by 63

Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response

Samokhvalov, V., Alsaleh, N. B., El-Sikhry, H. E., Jamieson, K. L., Chen, C. B., Lopaschuk, D. G., Carter, C., Light, P. E., Manne, R., Falck, J. R., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.418 · Cited by 64

Hormetic and regulatory effects of lipid peroxidation mediators in pancreatic beta cells

Maulucci, G., Daniel, B., Cohen, O., Avrahami, Y., & Sasson, S. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.03.001 · Cited by 63

Role of OSGIN1 in mediating smoking-induced autophagy in the human airway epithelium

Wang, G., Zhou, H., Strulovici‐Barel, Y., Al-Hijji, M. A., Ou, X., Salit, J., Walters, M. S., Staudt, M. R., Kaner, R. J., & Crystal, R. G. (2017) · Autophagy · doi:10.1080/15548627.2017.1301327 · Cited by 63

Wide-Acidity-Range pH Fluorescence Probes for Evaluation of Acidification in Mitochondria and Digestive Tract Mucosa

Chen, G., Fu, Q., Yu, F., Ren, R., Liu, Y., Cao, Z., Li, G., Zhao, X., Chen, L., Wang, H., et al. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b02164 · Cited by 62

miR‑30 decreases multidrug resistance in human gastric cancer cells by modulating cell autophagy

Du, X., Liu, B., Luan, X., Cui, Q., & Li, L. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5354 · Cited by 64

Smooth muscle cells and vascular diseases

Michel, J., Li, Z., & Lacolley, P. J. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs172 · Cited by 63

Protein-bound uremic toxins impaired mitochondrial dynamics and functions

Sun, C., Cheng, M., Pan, H., Lee, J.-H., & Lee, C. (2017) · Oncotarget · doi:10.18632/oncotarget.20773 · Cited by 62

Natural Compounds as Regulators of the Cancer Cell Metabolism

Cerella, C., Radogna, F., Dicato, M. A., & Diederich, M. F. (2013) · International Journal of Cell Biology · doi:10.1155/2013/639401 · Cited by 67

Effects of Methionine Supplementation on the Expression of Protein Deposition-Related Genes in Acute Heat Stress-Exposed Broilers

Vesco, A. P. D., Gasparino, E., Grieser, D. D. O., Zancanela, V. T., Voltolini, D. M., Khatlab, A. S., Guimarães, S. E. F., Soares, M. A. M., & Neto, A. R. O. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115821 · Cited by 62

Genetic, metabolic and environmental factors involved in the development of liver cirrhosis in Mexico

Ramos-López, O. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i41.11552 · Cited by 65

Phytol Induces Apoptosis and ROS-Mediated Protective Autophagy in Human Gastric Adenocarcinoma AGS Cells

(2015) · Biochemistry & Analytical Biochemistry · doi:10.4172/2161-1009.1000211 · Cited by 63

Autophagy and Mitophagy Promotion in a Rat Model of Endometriosis

Siracusa, R., D’Amico, R., Impellizzeri, D., Cordaro, M., Peritore, A. F., Gugliandolo, E., Crupi, R., Salinaro, A. T., Raffone, E., Genovese, T., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105074 · Cited by 61

Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy

Dai, C., Tang, S., Velkov, T., & Xiao, X. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9396-7 · Cited by 63

Synergism through combination of chemotherapy and oxidative stress-induced autophagy in A549 lung cancer cells using redox-responsive nanohybrids: A new strategy for cancer therapy

Lu, H.-Y., Chang, Y., Fan, N., Wang, L., Lai, N., Yang, C., Wu, L.-C., & Ho, J. A. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.11.029 · Cited by 61

Evaluation of the Toxicity and Antioxidant Activity of Redox Nanoparticles in Zebrafish (Danio rerio) Embryos

Vong, L. B., Kobayashi, M., & Nagasaki, Y. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00225 · Cited by 64

Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients

Want, A., Gillespie, S. R., Wang, Z., Gordon, R., Iomini, C., Ritch, R. H., Wolosin, J. M., & Bernstein, A. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157404 · Cited by 62

Melatonin as an endogenous regulator of diseases: The role of autophagy

Roohbakhsh, A., Shamsizadeh, A., Hayes, A. W., Reiter, R. J., & Karimi, G. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.022 · Cited by 59

Geraniol Protects Against the Protein and Oxidative Stress Induced by Rotenone in an In Vitro Model of Parkinson’s Disease

Rekha, K. R., & Sivakamasundari, R. I. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2617-5 · Cited by 61

ROS Promote Ox-LDL-Induced Platelet Activation by Up-Regulating Autophagy Through the Inhibition of the PI3K/AKT/mTOR Pathway

Wang, X., Fu, Y., Liu, X., Feng, G., Xiong, D., Mu, G., & Chen, F. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000494795 · Cited by 60

Autophagy Dysregulation in Diabetic Kidney Disease: From Pathophysiology to Pharmacological Interventions

González, C. D., Negueruela, M. P. C., Santamarina, C. N., Resnik, R., & Vaccaro, M. I. (2021) · Cells · doi:10.3390/cells10092497 · Cited by 61

Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria

Carvalho, C., & Moreira, P. I. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102694 · Cited by 63

The autophagy pathway maintained signaling crosstalk with the Keap1–Nrf2 system through p62 in auditory cells under oxidative stress

Hayashi, K., Dan, K., Goto, F., Tshuchihashi, N., Nomura, Y., Fujioka, M., Kanzaki, S., & Ogawa, K. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.11.024 · Cited by 60

Mitochondrial DNA Damage via Augmented Oxidative Stress Regulates Endoplasmic Reticulum Stress and Autophagy: Crosstalk, Links and Signaling

Yuzefovych, L. V., LeDoux, S. P., Wilson, G. L., & Rachek, L. I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083349 · Cited by 58

Depolarization Controls TRAIL-Sensitization and Tumor-Selective Killing of Cancer Cells: Crosstalk with ROS

Suzuki‐Karasaki, Y., Suzuki‐Karasaki, M., Uchida, M., & Ochiai, T. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00128 · Cited by 63

Hydrogen peroxide-induced mitophagy contributes to laryngeal cancer cells survival via the upregulation of FUNDC1

Hui, L., Wu, H., Wang, T.-W., Yang, N., Guo, X., & JANG, X. (2018) · Clinical & Translational Oncology · doi:10.1007/s12094-018-1958-5 · Cited by 59

Increased Oxidative Stress and Impaired Antioxidant Response in Lafora Disease

Mateo, C. R., Aguado, C., García‐Giménez, J. L., Ibáñez-Cabellos, J. S., Seco-Cervera, M., Pallardó, F. V., Knecht, E., & Sanz, P. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8747-0 · Cited by 59

Protective role of autophagy in methionine–choline deficient diet-induced advanced nonalcoholic steatohepatitis in mice

Chen, R., Wang, Q., Song, S., Liu, F., He, B., & Gao, X. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.11.012 · Cited by 59

Bixin ameliorates high fat diet-induced cardiac injury in mice through inflammation and oxidative stress suppression

Zhou, X., & Kong, X. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.052 · Cited by 59

Linking Mitochondrial Dysfunction to Organismal and Population Health in the Context of Environmental Pollutants: Progress and Considerations for Mitochondrial Adverse Outcome Pathways

Dreier, D. A., Mello, D. F., Meyer, J. N., & Martyniuk, C. J. (2019) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4453 · Cited by 57

Enhanced endoplasmic reticulum and mitochondrial stress in abdominal aortic aneurysm

Navas‐Madroñal, M., Rodrı́guez, C., Kassan, M., Fité, J., Escudero, J. R., Cañes, L., Martínez‐González, J., Camacho, M., & Galán, M. (2019) · Clinical Science · doi:10.1042/cs20190399 · Cited by 59

Silver Nanoparticles Stimulate Osteogenesis of Human Mesenchymal Stem Cells Through Activation of Autophagy

He, W., Zheng, Y., Feng, Q., Elkhooly, T. A., Liu, X., Yang, X., Wang, Y., & Xie, Y. (2020) · Nanomedicine · doi:10.2217/nnm-2019-0026 · Cited by 57

Emodin Induces Apoptosis of Colon Cancer Cells via Induction of Autophagy in a ROS-Dependent Manner

Wang, Y., Luo, Q. F., He, X., Wei, H., Wang, T., Shao, J., & Jiang, X. (2017) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504017x15009419625178 · Cited by 58

Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium

Goitre, L., DiStefano, P. V., Moglia, A., Nobiletti, N., Baldini, E., Trabalzini, L., Keubel, J., Trapani, E., Shuvaev, V. V., Muzykantov, V. R., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08373-4 · Cited by 59

Cellular Stress and General Pathological Processes

Gusev, E. Y., & Zotova, N. V. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190319114641 · Cited by 64

The Interplay Between Apoptosis, Mitophagy and Mitochondrial Biogenesis Induced by Resveratrol Can Determine Activated Hepatic Stellate Cells Death or Survival

Martins, L. A. M., Vieira, M. Q., Ilha, M., de Vasconcelos, M., Biehl, H. B., de Lima, D. B., Schein, V., Barbé‐Tuana, F. M., Borojević, R., & Guma, F. T. C. R. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-0245-5 · Cited by 60

Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus

San‐Miguel, B., Crespo, I., Vallejo, D., Alvarez, M., Prìeto, J., González‐Gallego, J., & Tuñón, M. J. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12124 · Cited by 58

Mitochondria dysfunction in lung cancer-induced muscle wasting in C2C12 myotubes

McLean, J. B., Moylan, J. S., & Andrade, F. H. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00503 · Cited by 63

The protective role of autophagy in nephrotoxicity induced by bismuth nanoparticles through AMPK/mTOR pathway

Liu, Y., Yu, H., Zhang, X., Wang, Y., Song, Z., Zhao, J., Shi, H., Li, R., Wang, Y., & Zhang, L. W. (2018) · Nanotoxicology · doi:10.1080/17435390.2018.1466932 · Cited by 58

Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: implications for mitochondrial therapeutics

Mitchell, T., Chacko, B., Ballinger, S. W., Bailey, S. M., Zhang, J., & Darley-Usmar, V. (2013) · Biochemical Society Transactions · doi:10.1042/bst20120231 · Cited by 57

Mitophagy receptors sense stress signals and couple mitochondrial dynamic machinery for mitochondrial quality control

Wu, H., Wei, H., Sehgal, S. A., Liu, L., & Chen, Q. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.03.030 · Cited by 58

The Intertwined Roles of Oxidative Stress and Endoplasmic Reticulum Stress in Glaucoma

Hurley, D. J., Normile, C., Irnaten, M., & O'Brien, C. J. (2022) · Antioxidants · doi:10.3390/antiox11050886 · Cited by 64

Radiation persistently promoted oxidative stress, activated mTOR via PI3K/Akt, and downregulated autophagy pathway in mouse intestine

Datta, K., Suman, S., & Fornace, A. J. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.10.022 · Cited by 57

Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts

Liang, Q., Benavides, G. A., Vassilopoulos, A., Gius, D. R., Darley-Usmar, V. M., & Zhang, J. (2013) · Biochemical Journal · doi:10.1042/bj20130414 · Cited by 58

Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells

Dodson, M. B., Liang, Q., Johnson, M. S., Redmann, M., Fineberg, N. S., Darley-Usmar, V. M., & Zhang, J. (2013) · Autophagy · doi:10.4161/auto.26094 · Cited by 57

Combining myeloperoxidase (MPO) with fluorogenic ZnSalen to detect lysosomal hydrogen peroxide in live cells

Jing, J., & Zhang, J. (2013) · Chemical Science · doi:10.1039/c3sc50807b · Cited by 57

Mitochondrial dysfunction and respiratory chain defects in a rodent model of methotrexate-induced enteritis

Kolli, V. K., Natarajan, K., Isaac, B. T. J., Selvakumar, D., & Abraham, P. (2013) · Human & Experimental Toxicology · doi:10.1177/0960327113515503 · Cited by 57

The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment

Wilson, G. J., Bunpo, P., Cundiff, J. K., Wek, R. C., & Anthony, T. G. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00080.2013 · Cited by 57

Autophagy and ageing: implications for age-related neurodegenerative diseases

Carroll, B., Hewitt, G., & Korolchuk, V. I. (2013) · Essays in Biochemistry · doi:10.1042/bse0550119 · Cited by 60

REVIEW ARTICLE Autophagy, mitochondria and oxidative stress: cross-talk and redox

Lee, J., Giordano, S. S., & Zhang, J. (2013)

Roles of Autophagy in Oxidative Stress

Yun, H. R., Jo, Y. H., Kim, J., Shin, Y., Kim, S. S., & Choi, T. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093289 · Cited by 413

The Roles of Autophagy in Oxidative Stress.

Mehrdar, M. T., & Rasool, M. (2025) · PubMed · doi:10.32598/ari.80.6.3391

Redox homeostasis, oxidative stress and mitophagy

Garza-Lombó, C., Pappa, A., Panayiotidis, M. I., & Franco, R. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.01.002 · Cited by 168

Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival

Navarro-Yepes, J., Burns, M., Anandhan, A., Khalimonchuk, O., Razo, L. M. D., Quintanilla‐Vega, B., Pappa, A., Panayiotidis, M. I., & Franco, R. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5837 · Cited by 467