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Kidney neutral endopeptidase and the hydrolysis of enkephalin by synaptic membranes show similar sensitivity to inhibitors
Open accessAbstract
Neutral endopeptidase (EC 3.4.24.11) from pig kidney hydrolyses [125I]iodo-insulin B-chain and leucine-enkephalin. Both activities were equally sensitive to inhibition by phosphoramidon [N-(alpha-L-rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan] and thiorphan [N-(DL-2-benzyl-3-mercaptopropionyl)glycine]. Thermolysin hydrolysis of insulin B-chain was also sensitive to both inhibitors. The hydrolysis of the Gly3-Phe4 bond of Leu-enkephalin by synaptic membranes prepared from pig brain was partially inhibited by phosphoramidon and thiorphan. Synaptic membranes appear to contain another endopeptidase activity that is insensitive to these reagents. These observations suggest that enzymes similar to the kidney endopeptidase may play a general role in neuropeptide metabolism.
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Cited by
Matsas, R., Fulcher, I. S., Kenny, A. J., & Turner, A. J. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.10.3111 · Cited by 372
Self-citationMatsas, R., Kenny, A. J., & Turner, A. J. (1984) · Biochemical Journal · doi:10.1042/bj2230433 · Cited by 370
Self-citationZhao, W.-Q., & Townsend, M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.014 · Cited by 291
Neutral metalloendopeptidase in human lung tissue and cultured cells.
Johnson, A. R., Ashton, J. H., Schulz, W., & Erdös, E. G. (1985) · PubMed · doi:10.1164/arrd.1985.132.3.564 · Cited by 253
Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?
Nalivaeva, N. N., Beckett, C., Belyaev, N. D., & Turner, A. J. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07510.x · Cited by 169
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Metadata
- Authors
- Fulcher, I. S., Matsas, R., Turner, A. J., & Kenny, A. J.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1982-05-01
- Volume
- 203
- Issue
- 2
- Pages
- 519-522
- ISSN
- 0264-6021 (ISSN-L)
- OpenAlex
- W2139592625
- Cited by
- 172
- References
- 0
- FWCI
- 12.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fulcher, I. S., Matsas, R., Turner, A. J., & Kenny, A. J. (1982). Kidney neutral endopeptidase and the hydrolysis of enkephalin by synaptic membranes show similar sensitivity to inhibitors. Biochemical Journal. https://doi.org/10.1042/bj2030519
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