The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Receptor-mediated net breakdown of phosphatidylinositol 4,5-bisphosphate in parotid acinar cells
Open accessAbstract
The metabolism of phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] in rat parotid acinar cells was investigated, particularly with regard to the effects of receptor-active agonists. Stimulation of cholinergic-muscarinic receptors with methacholine provoked a rapid disappearance of 40-50% of [32P]PtdIns(4,5)P2, but had no effect on PtdIns4P. Adrenaline, acting on alpha-adrenoceptors, and Substance P also stimulated net loss of PtdIns(4,5)P2. The beta-adrenoceptor agonist, isoprenaline, and the Ca2+ ionophore, ionomycin, failed to affect labelled PtdIns(4,5)P2 or PtdIns4P. By chelation of extracellular Ca2+ with excess EGTA, and by an experimental protocol that eliminates cellular Ca2+ release, it was demonstrated that the agonist-induced decrease in PtdIns(4,5)P2 is independent of both Ca2+ influx and Ca2+ release. These results may suggest that net PtdIns(4,5)P2 breakdown is an early event in the stimulus-response pathway of the parotid acinar cell and could be directly involved in the mechanism of agonist-induced Ca2+ release from the plasma membrane.
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Cites
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Cited by
Berridge, M. J., Dawson, R. M. C., Downes, C. P., Heslop, J. P., & Irvine, R. F. (1983) · Biochemical Journal · doi:10.1042/bj2120473 · Cited by 1,954
The O2−-forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function
Rossi, F. (1986) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(86)90005-4 · Cited by 658
Effect of inositol-1,4,5-trisphosphate on isolated subcellular fractions of rat pancreas
Streb, H., Bayerdörffer, E., Haase, W., Irvine, R. F., & Schulz, I. (1984) · The Journal of Membrane Biology · doi:10.1007/bf01868717 · Cited by 311
Metadata
- Authors
- Weiss, S. J., McKinney, J. S., & Putney, J. W.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1982-09-15
- Volume
- 206
- Issue
- 3
- Pages
- 555-560
- ISSN
- 0264-6021 (ISSN-L)
- OpenAlex
- W2276848662
- Cited by
- 184
- References
- 1
- FWCI
- 15.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Weiss, S. J., McKinney, J. S., & Putney, J. W. (1982). Receptor-mediated net breakdown of phosphatidylinositol 4,5-bisphosphate in parotid acinar cells. Biochemical Journal. https://doi.org/10.1042/bj2060555
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
