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Down-regulation of protein kinase C is due to an increased rate of degradation
Open accessAbstract
The phorbol-ester-induced loss of protein kinase C that has been documented in many cell types appears to be a critical event in the generation of a cellular refractory state. We have investigated here the synthesis and degradation of the protein kinase C polypeptide in order to determine why its steady-state amounts are depleted in response to phorbol esters. These results indicate that depletion is due to an increased rate of degradation, with no change either in mRNA amounts or in rates of polypeptide synthesis.
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Citations
Cited by
Schönwasser, D. C., Marais, R. M., Marshall, C. J., & Parker, P. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.790 · Cited by 760
Self-citationGENETIC ANALYSIS OF THE MULTIDRUG TRANSPORTER
Gottesman, M. M., Hrycyna, C. A., Schoenlein, P. V., Germann, U. A., & Pastan, I. (1995) · Annual Review of Genetics · doi:10.1146/annurev.ge.29.120195.003135 · Cited by 478
Stabel, S., & Parker, P. J. (1991) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(91)90042-k · Cited by 408
Self-citationActivation of protein kinase C inhibits cellular production of the amyloid beta-protein.
Hung, A. Y., Haass, C., Nitsch, R. M., Qiu, W. Q., Citron, M., Wurtman, R. J., Growdon, J. H., & Selkoe, D. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49409-x · Cited by 405
Activation of Protein Kinase C Triggers Its Ubiquitination and Degradation
Lu, Z., Liu, D., Hornia, A., Devonish, W., Pagano, M., & Foster, D. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.839 · Cited by 334
Metadata
- Authors
- Young, S., Parker, P. J., Ullrich, A., & Stabel, S.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1987-06-15
- Volume
- 244
- Issue
- 3
- Pages
- 775-779
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2410473994
- Cited by
- 430
- References
- 0
- FWCI
- 10.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Young, S., Parker, P. J., Ullrich, A., & Stabel, S. (1987). Down-regulation of protein kinase C is due to an increased rate of degradation. Biochemical Journal. https://doi.org/10.1042/bj2440775
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
