The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts
Open accessAbstract
The effect of various growth factors on the synthesis of hyaluronan in human fibroblasts was investigated. When tested in medium containing 0.5% fetal calf serum, platelet-derived growth factor (PDGF)-BB was found to stimulate hyaluronan synthesis; the maximal response was equal to or higher than that obtained with 10% fetal calf serum. PDGF-AA gave only a limited effect, indicating that the stimulatory effect of PDGF on hyaluronan synthesis was mainly transduced via the B-type PDGF receptor. Epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) and transforming growth factor (TGF)-beta 1 also stimulated hyaluronan synthesis; their effects were less than that of PDGF-BB, but combinations of factors produced potent stimulatory effects on hyaluronan synthesis. All factors stimulated hyaluronan synthesis in sparse as well as dense cultures. The effects of the factors on hyaluronan synthesis did not correlate with their mitogenic activities; PDGF-BB, EGF and bFGF are equipotent mitogens, but PDGF-BB had a much more potent effect on hyaluronan synthesis, and TGF-beta actually inhibits the growth of fibroblasts under the conditions of the assay.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Cell adhesion protein receptors as targets for transforming growth factor-$beta; action
IGNOTZ, R. (1987) · Cell · doi:10.1016/0092-8674(87)90146-2 · Cited by 485
Cited by
Reduced expression of PDGF and PDGF receptors during impaired wound healing
Beer, H.-D., Longaker, M. T., & Werner, S. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12319188 · Cited by 257
Riessen, R., Wight, T. N., Pastore, C., Henley, C., & Isner, J. M. (1996) · Circulation · doi:10.1161/01.cir.93.6.1141 · Cited by 175
GENTILE, V., MODESTI, A., LA PERA, G., VASATURO, F., MODICA, A., PRIGIOTTI, G., DI SILVERIO, F., & SCARPA, S. (1996) · Journal of Andrology · doi:10.1002/j.1939-4640.1996.tb01757.x · Cited by 35
Metadata
- Authors
- Heldin, P., Laurent, T. C., & Heldin, C. H.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1989-03-15
- Volume
- 258
- Issue
- 3
- Pages
- 919-922
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W32471076
- Cited by
- 291
- References
- 2
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts. https://app.cochat.ai/papers/10.1042/bj2580919
- The paper
- Heldin, P., Laurent, T. C., & Heldin, C. H. (1989). Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts. Biochemical Journal. https://doi.org/10.1042/bj2580919
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
