Cited by 225Redox biology and oxidative stressFree Radicals and AntioxidantsAntioxidant Activity and Oxidative Stress

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Long-lived reactive species on free-radical-damaged proteins

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Simpson, J A, Narita, S, Gieseg, S, Gebicki, S, Gebicki, J M, Dean, R T·1992·Biochemical Journal

DOI 10.1042/bj2820621PMC PMC1130831

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Abstract

We have demonstrated two novel reactive species on radical-modified proteins which are relatively long-lived, one oxidizing and one reducing. The two species are reactive with critical biological components, and so may be of physiological and pathological importance. The oxidizing species, which have been identified as protein hydroperoxides, can consume key cellular reductants, such as ascorbate and glutathione. The reducing species can act on both free and metalloprotein forms of copper and iron ions, which participate in radical generation. These findings suggest that proteins may act as traps for the chemical energy released by free radicals, with the capacity to pass it on to other molecules. The long-lived nature of both the reactive moieties indicates that they may be able to diffuse and transfer damaging reactions to distant sites.

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Authors: Simpson, J. A., Narita, S., Gieseg, S., Gebicki, S., Gebicki, J. M., & Dean, R. T.
Affiliations: The Heart Research Institute (AU)
Macquarie University (AU)
Corresponding author: Gieseg, S
ORCID: Simpson, J A
Gieseg, S
Gebicki, J M
Dean, R T
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 1992-03-15
Volume: 282
Issue: 3
Pages: 621-624
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj2820621
PMC: PMC1130831
OpenAlex: W2404844012
Cited by: 225
References: 23
Citations by year: 2026: 2 · 2025: 4 · 2023: 5 · 2021: 6 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 7 · 2013: 8 · 2012: 9
FWCI: 4.10
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Heart Research Institute
Medical Research Council
Australian Research Council
National Health and Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: reactive oxygen species, vitamin C, glutathione, copper ions, iron ions, metalloproteins, free radical generation, energy transfer, protein oxidation
MeSH terms: Amino Acids, Free Radicals, Metals, Oxidation-Reduction, Peroxides, Proteins

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Long-lived reactive species on free-radical-damaged proteins

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