The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Oxidative stress and ageing in Caenorhabditis elegans
Open accessAbstract
Mutations in the age-1 gene double both the mean and maximum life span of Caenorhabditis elegans. They also result in an age-specific increase of catalase and Cu/Zn superoxide dismutase activity levels. The higher superoxide dismutase activity levels in age-1 mutants confer hyperresistance to the superoxide-anion-generating drug paraquat. The rate of superoxide anion production by microsome fractions declines linearly with age in age-1(+) worms, but, after an initial decline, is stabilized at a higher level in senescent age-1 mutant nematodes. These results clearly show that oxidative stress resistance and potential life span are correlated in this organism, and they suggest that the natural product of age-1 either directly or indirectly downregulates the activities of several other genes as a function of age.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Aebi, H. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05016-3 · Cited by 25,696
[12] Assays of glutathione peroxidase
Flohé, L., & Günzler, W. A. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05015-1 · Cited by 4,951
The Nematode Caenorhabditis elegans
Wood, W. B. (1988) · Cold Spring Harbor Laboratory eBooks · Cited by 2,820
Harman, D. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.7124 · Cited by 1,915
Evolution of senescence: late survival sacrificed for reproduction
Kirkwood, T. B. L., & Rose, M. R. (1991) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1991.0028 · Cited by 1,116
Friedman, D. B., & Johnson, T. E. (1988) · Genetics · doi:10.1093/genetics/118.1.75 · Cited by 1,010
[41] Preparation and assay of superioxide dismutases
Crapo, J. D., McCord, J. M., & Fridovich, I. (1978) · Methods in Enzymology · doi:10.1016/s0076-6879(78)53044-9 · Cited by 685
Klass, M. R. (1983) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(83)90082-9 · Cited by 447
[61] Assay of superoxide dismutase activity in tumor tissue
Oberley, L. W., & Spitz, D. R. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05064-3 · Cited by 420
Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species.
Tolmasoff, J. M., Ono, T., & Cutler, R. G. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.2777 · Cited by 383
Cited by
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879
Schulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., & Ristow, M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.011 · Cited by 1,209
Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics
Melov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P. E., Wallace, D. C., Malfroy, B., Doctrow, S. R., & Lithgow, G. J. (2000) · Science · doi:10.1126/science.289.5484.1567 · Cited by 912
Morris, J. Z., Tissenbaum, H. A., & Ruvkun, G. (1996) · Nature · doi:10.1038/382536a0 · Cited by 891
Metadata
- Authors
- Vanfleteren, J. R.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1993-06-01
- Volume
- 292
- Issue
- 2
- Pages
- 605-608
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W1809054409
- Cited by
- 383
- References
- 17
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Oxidative stress and ageing in Caenorhabditis elegans. https://app.cochat.ai/papers/10.1042/bj2920605
- The paper
- Vanfleteren, J. R. (1993). Oxidative stress and ageing in Caenorhabditis elegans. Biochemical Journal. https://doi.org/10.1042/bj2920605
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
