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Autocrine regulation of milk secretion by a protein in milk
Open accessAbstract
Frequency or completeness of milk removal from the lactating mammary gland regulates the rate of milk secretion by a mechanism which is local, chemical and inhibitory in nature. Screening of goat's milk proteins in rabbit mammary explant cultures identified a single whey protein of M(r) 7600 able to inhibit synthesis of milk constituents. The active whey protein, which we term FIL (Feedback inhibitor of Lactation), also decreased milk secretion temporarily when introduced into a mammary gland of lactating goats. FIL was synthesized by primary cultures of goat mammary epithelial cells, and was secreted vectorially together with other milk proteins. N-terminal amino acid sequencing indicated that it is a hitherto unknown protein. The evidence indicates that local regulation of milk secretion by milk removal is through autocrine feedback inhibition by this milk protein.
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Cited by
Recent advances in exploiting goat's milk: Quality, safety and production aspects
Silanikove, N., Leitner, G., Merin, U., & Prosser, C. G. (2010) · Small Ruminant Research · doi:10.1016/j.smallrumres.2009.12.033 · Cited by 432
Transport of Milk Constituents by the Mammary Gland
Shennan, D. B., & Peaker, M. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.925 · Cited by 411
Self-citationLipid metabolism in the lactating mammary gland
Barber, M. C., Clegg, R. A., Travers, M. T., & Vernon, R. G. (1997) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/s0005-2760(97)00079-9 · Cited by 274
Apoptosis and mammary gland involution: reviewing the process
Furth, P. A., Bar-Peled, U., & Li, M. (1997) · Apoptosis · doi:10.1023/a:1026454207398 · Cited by 28
Metadata
- Authors
- Wilde, C. J., Addey, C. V. P., Boddy, L. M., & Peaker, M.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1995-01-01
- Volume
- 305
- Issue
- 1
- Pages
- 51-58
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W1849905416
- Cited by
- 214
- References
- 0
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Autocrine regulation of milk secretion by a protein in milk. https://app.cochat.ai/papers/10.1042/bj3050051
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- Wilde, C. J., Addey, C. V. P., Boddy, L. M., & Peaker, M. (1995). Autocrine regulation of milk secretion by a protein in milk. Biochemical Journal. https://doi.org/10.1042/bj3050051
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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