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Zeta, a novel class of glutathione transferases in a range of species from plants to humans
Open accessAbstract
Sequence alignment and phylogenetic analysis has identified a new subgroup of glutathione S-transferase (GST)-like proteins from a range of species extending from plants to humans. This group has been termed the Zeta class. An atomic model of the N-terminal domain suggests that the members of the Zeta class have a similar structure to that of other GSTs, binding glutathione in a similar orientation in the G site. Recombinant human GSTZ1-1 has been expressed in Escherichia coli and characterized. The protein is a dimer composed of 24.2 kDa subunits and has minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole. Although low in comparison with other GSTs, GSTZ1-1 has glutathione peroxidase activity with t-butyl and cumene hydroperoxides. The members of the Zeta class have been conserved over a long evolutionary period, suggesting that they might have a role in the metabolism of a compound that is common in many living cells.
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Cited by
SHEEHAN, D., MEADE, G., FOLEY, V. M., & DOWD, C. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3600001 · Cited by 3,057
Insect glutathione transferases and insecticide resistance
Enayati, A. A., Ranson, H., & Hemingway, J. (2005) · Insect Molecular Biology · doi:10.1111/j.1365-2583.2004.00529.x · Cited by 1,084
Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases
Board, P. G., Coggan, M., Chelvanayagam, G., Easteal, S., Jermiin, L. S., Schulte, G. K., Danley, D. E., Hoth, L. R., Griffor, M. C., Kamath, A. V., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001706200 · Cited by 722
Self-citationCharacterization of the human Omega class glutathione transferase genes and associated polymorphisms
Whitbread, A. K., Tetlow, N., Eyre, H. J., Sutherland, G. R., & Board, P. G. (2003) · Pharmacogenetics · doi:10.1097/00008571-200303000-00003 · Cited by 181
Enzymatic defluorination of fluorinated compounds
Seong, H. J., Kwon, S. W., Seo, D.-C., Kim, J.-H., & Jang, Y.-S. (2019) · Applied Biological Chemistry · doi:10.1186/s13765-019-0469-6 · Cited by 53
Metadata
- Authors
- BOARD, G. P., BAKER, T. R., CHELVANAYAGAM, G., & JERMIIN, S. L.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1997-12-15
- Volume
- 328
- Issue
- 3
- Pages
- 929-935
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W11118004
- Cited by
- 496
- References
- 0
- FWCI
- 9.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Zeta, a novel class of glutathione transferases in a range of species from plants to humans. https://app.cochat.ai/papers/10.1042/bj3280929
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- BOARD, G. P., BAKER, T. R., CHELVANAYAGAM, G., & JERMIIN, S. L. (1997). Zeta, a novel class of glutathione transferases in a range of species from plants to humans. Biochemical Journal. https://doi.org/10.1042/bj3280929
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
