Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
SHEPHERD, Peter R., WITHERS, Dominic J., SIDDLE, Kenneth·1998·Biochemical Journal
Cites (338)
Items 201–335 of 335
- Membrane-permeant Esters of Phosphatidylinositol 3,4,5-TrisphosphateTao Jiang, Gary Sweeney, Marco T. Rudolf, Amira Klip, Alexis Traynor‐Kaplan, Roger Y. Tsien · 1998 · Journal of Biological Chemistry
- Phosphatidylinositol 3-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcriptionK. Yamauchi, Kathleen H. Holt, Jeffrey E. Pessin · 1993 · Journal of Biological Chemistry
- Insulin Receptor Substrate 1 Binds Two Novel Splice Variants of the Regulatory Subunit of Phosphatidylinositol 3-Kinase in Muscle and BrainDavid A. Antonetti, Petra Algenstaedt, C. Ronald Kahn · 1996 · Molecular and Cellular Biology
- Lipid Products of Phosphoinositide 3-Kinase Bind Human Profilin with High AffinityPei‐Jung Lu, Woan-Ru Shieh, Sue Goo Rhee, Helen L. Yin, Ching‐Shih Chen · 1996 · Biochemistry
- Requirement for Phosphoinositide 3-Kinase in Insulin-Stimulated GLUT4 Translocation in 3T3-L1 AdipocytesKo Kotani, Amanda Carozzi, Hiroshi Sakaue, Kanako Hara, Linda J. Robinson, Sharon F. Clark, Kazuyoshi Yonezawa, David Ernest James, Masato Kasuga · 1995 · Biochemical and Biophysical Research Communications
- Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution.K.L. Kelly, Neil B. Ruderman, K S Chen · 1992 · Journal of Biological Chemistry
- Identification and Cloning of Centaurin-αLatanya P. Hammonds-Odie, Trevor Jackson, Adam A. Profit, Ira J. Blader, Christoph W. Turck, Glenn D. Prestwich, Anne B. Theibert · 1996 · Journal of Biological Chemistry
- Growth Hormone Stimulates the Tyrosine Phosphorylation of the Insulin Receptor Substrate-1 and Its Association with Phosphatidylinositol 3-Kinase in Primary AdipocytesMartin Ridderstråle, Eva Degerman, Hans E. Tornqvist · 1995 · Journal of Biological Chemistry
- Platelet-Derived Growth Factor-Dependent Activation of Phosphatidylinositol 3-Kinase Is Regulated by Receptor Binding of SH2-Domain-Containing Proteins Which Influence Ras ActivityRichard A. Klinghoffer, Brian C. Duckworth, Mindaugas Valius, Lewis C. Cantley, Andrius Kazlauskas · 1996 · Molecular and Cellular Biology
- Expression of a Constitutively Active Phosphatidylinositol 3-Kinase Induces Process Formation in Rat PC12 CellsMichimoto Kobayashi, Satoshi Nagata, Yoshihiro Kita, Noriyuki Nakatsu, Sayoko Ihara, Kozo Kaibuchi, Shinya Kuroda, Motoyasu Ui, Hideo Iba, Hiroaki Konishi et al. · 1997 · Journal of Biological Chemistry
- Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytesBARBARA T. NAVÉ, J RichardHAIGH, Amanda C. Hayward, Kenneth Siddle, Peter Robin Shepherd · 1996 · Biochemical Journal
- Constitutive activation of protein kinase B and phosphorylation of p47 phox by a membrane-targeted phosphoinositide 3-kinaseSvetlana A. Didichenko, Bettina Tilton, Brian A. Hemmings, Kurt Ballmer‐Hofer, Marcus Thelen · 1996 · Current Biology
- Essential role of phosphatidylinositol 3‐kinase in insulin‐induced activation and phosphorylation of the cGMP‐inhibited cAMP phosphodiesterase in rat adipocytes studies using the selective inhibitor wortmanninTova Rahn Landström, Martin Ridderstråle, Hans E. Tornqvist, Vincent C. Manganiello, Gudrun Fredrikson, Per Belfrage, Eva Degerman · 1994 · FEBS Letters
- Activation of PRK1 by Phosphatidylinositol 4,5-Bisphosphate and Phosphatidylinositol 3,4,5-TrisphosphateRuth Helen Palmer, Lodewijk V. Dekker, Rüdiger Woscholski, J. Ann Le Good, Roy Gigg, Peter J. Parker · 1995 · Journal of Biological Chemistry
- Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.Byung Hak Jhun, David W. Rose, B. Lynn Seely, Lucia E. Rameh, Lewis C. Cantley, Alan R. Saltiel, Jerrold M. Olefsky · 1994 · Molecular and Cellular Biology
- Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.Debra J. Van Horn, Martin Grosvenor Myers, Jonathan Backer · 1994 · Journal of Biological Chemistry
- Analysis of the Signaling Pathway Involved in the Regulation of Hexokinase II Gene Transcription by InsulinOsawa, Haruhiko, Sutherland, Calum, Robey, R. Brooks, Printz, Richard L., Granner, Daryl K. · 1996 · Journal of Biological Chemistry
- Synergistic Activation of Dynamin GTPase by Grb2 and PhosphoinositidesBarbara Baryłko, Derk D. Binns, Keng-Mean Lin, Mark A. Atkinson, David M. Jameson, Helen L. Yin, Joseph P. Albanesi · 1998 · Journal of Biological Chemistry
- Insulin activates the appearance of insulin-like growth factor II receptors on the adipocyte cell surface.Y. Oka, Cristina Mottola, Catherine Oppenheimer, Michael Czech · 1984 · Proceedings of the National Academy of Sciences
- Insulin-Induced Phosphorylation and Activation of Phosphodiesterase 3B in Rat Adipocytes: Possible Role for Protein Kinase B But Not Mitogen-Activated Protein Kinase or p70 S6 KinaseJonny Wijkander, Tova Rahn Landström, Vincent C. Manganiello, Per Belfrage, Eva Degerman · 1998 · Endocrinology
- A Novel 55-kDa Regulatory Subunit for Phosphatidylinositol 3-Kinase Structurally Similar to p55PIK Is Generated by Alternative Splicing of the p85α GeneKouichi Inukai, Motonobu Anai, Eric van Breda, Toshio Hosaka, Hideki Katagiri, Makoto Funaki, Yasushi Fukushima, Takehide Ogihara, Yoshio Yazaki, Masatoshi Kikuchi et al. · 1996 · Journal of Biological Chemistry
- Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.Yaron R. Hadari, Eldad Tzahar, Orna Nadiv, Paul Rothenberg, Charles T. Roberts, Derek LeRoith, Yosef Yarden, Yehiel Zick · 1992 · Journal of Biological Chemistry
- The Activation of Glycogen Synthase by Insulin Switches from Kinase Inhibition to Phosphatase Activation during Adipogenesis in 3T3-L1 CellsMatthew Brady, Francis Bourbonais, Alan R. Saltiel · 1998 · Journal of Biological Chemistry
- Phosphoinositide 3-kinases and membrane trafficPeter Robin Shepherd, Barbara J. Reaves, Howard W. Davidson · 1996 · Trends in Cell Biology
- Phosphoinositide 3-Kinase Activity Is Necessary for Insulin-dependent Inhibition of Apolipoprotein B Secretion by Rat Hepatocytes and Localizes to the Endoplasmic ReticulumThuy L. Phung, Angela M. Roncone, Karen L. de Mesy Jensen, Charles E. Sparks, Janet D. Sparks · 1997 · Journal of Biological Chemistry
- The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase.Brian E. Lavan, Gustav E. Lienhard · 1993 · Journal of Biological Chemistry
- A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth-muscle cellsPamela Scott, Christopher M. BELHAM, Jenan Al-Hafidh, Edwin R. Chilvers, Andrew J. Peacock, Gwyn W. Gould, Robin J. Plevin · 1996 · Biochemical Journal
- Structural Organization and Alternative Splicing of the Murine Phosphoinositide 3-Kinase p85α GeneDavid A. Fruman, Lewis C. Cantley, Christopher L. Carpenter · 1996 · Genomics
- Tyrosine Phosphorylation of Insulin Receptor Substrate-1 in Vivo Depends upon the Presence of Its Pleckstrin Homology RegionHedva Voliovitch, Daniel G. Schindler, Yaron R. Hadari, Simeon I. Taylor, Domenico Accili, Yehiel Zick · 1995 · Journal of Biological Chemistry
- Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1.Kazuyoshi Yonezawa, H Ueda, Kenta Hara, K Nishida, Akifumi Ando, Alain Chavanieu, H. Matsuba, Kozui Shii, Koichi Yokono, Yoshinori Fukui · 1992 · Journal of Biological Chemistry
- jun N-terminal Kinase Mediates Activation of Skeletal Muscle Glycogen Synthase by Insulin in VivoChristopher M. Moxham, Ali Tabrizchi, Roger J. Davis, Craig C. Malbon · 1996 · Journal of Biological Chemistry
- Pleiotropic Insulin Signals are Engaged by Multisite Phosphorylation of IRS-1Xiao‐Jian Sun, Dan L. Crimmins, Martin Grosvenor Myers · 1993 · Molecular and Cellular Biology
- Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cellsS. Kelly MOULE, NIGEL J. EDGELL, Gavin Iain Welsh, Tricia A. Diggle, Emily J. Foulstone, Kate J. Heesom, Christopher G. Proud, Richard M. Denton · 1995 · Biochemical Journal
- Wortmannin, a Specific Phosphatidylinositol 3-Kinase Inhibitor, Inhibits Adipocytic Differentiation of 3T3-L1 CellsKoji Tomiyama, Hiroko Nakata, Hidenori Sasa, Shinya Arimura, Eisuke Nishio, Yuji Watanabe · 1995 · Biochemical and Biophysical Research Communications
- Upstream Mechanisms of Glycogen Synthase Activation by Insulin and Insulin-like Growth Factor-IRitsuko Yamamoto‐Honda, Kazuyuki Tobe, Yasushi Kaburagi, Kohjiro Ueki, S. Asai, Makoto Yachi, Mikako Shirouzu, Junji Yodoi, Yasuo Akanuma, Shigeyuki Yokoyama et al. · 1995 · Journal of Biological Chemistry
- Phosphoinositide 3-Kinase Binds Constitutively to α/β-Tubulin and Binds to γ-Tubulin in Response to InsulinRosana Kapeller, Alex Toker, Lewis C. Cantley, Christopher L. Carpenter · 1995 · Journal of Biological Chemistry
- Activation of translation initiation factor eIF2B by insulin requires phosphatidyl inositol 3‐kinaseGavin Iain Welsh, Christa M. Stokes, Xuemin Wang, Hiroshi Sakaue, Wataru Ogawa, Masato Kasuga, Christopher G. Proud · 1997 · FEBS Letters
- Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3-KinaseJing Wang, Kurt R. Auger, Lesley A. Jarvis, Yang Shi, Thomas M. Roberts · 1995 · Journal of Biological Chemistry
- Potential Role of Rab4 in the Regulation of Subcellular Localization of Glut4 in AdipocytesMireille Cormont, Marie-Noëlle Bortoluzzi, Nadine Gautier, Muriel C. Mari, Emmanuel VAN OBBERGHEN, Yannick LE MARCHAND‐BRUSTEL · 1996 · Molecular and Cellular Biology
- The association of insulin-elicited phosphotyrosine proteins with src homology 2 domains.Brian E. Lavan, Michelle R. Kuhné, Charles W. Garner, Dirk M. Anderson, Michael Reedijk, Tony J. Pawson, Gustav E. Lienhard · 1992 · Journal of Biological Chemistry
- Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase γ: structure–activity analysis and interactions with wortmanninStefka STOYANOVA, Ginette Bulgarelli-Leva, Cornelia Kirsch, Theodor Hanck, R Klinger, Reinhard Wetzker, Matthias P. Wymann · 1997 · Biochemical Journal
- Insulin-like Growth Factors Require Phosphatidylinositol 3-Kinase to Signal Myogenesis: Dominant Negative p85 Expression Blocks Differentiation of L6E9 Muscle CellsPerla Kaliman, Judith Canicio, Peter Robin Shepherd, Carolyn A. Beeton, Xavier Testar, Manuel Palacı́n, António Zorzano · 1998 · Molecular Endocrinology
- Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes.Diane C. Fingar, Sharon F. Hausdorff, John Blenis, Morris J. Birnbaum · 1993 · Journal of Biological Chemistry
- Insulin Regulation of Glucose-6-phosphate Dehydrogenase Gene Expression Is Rapamycin-sensitive and Requires Phosphatidylinositol 3-KinaseAsavari Wagle, Sanjay Jivraj, Ginny Lynn Garlock, Susan Rutledge Stapleton · 1998 · Journal of Biological Chemistry
- Regulation of AP-3 Function by InositidesWeihua Hao, Zheng Lin Tan, Kondury Prasad, K. Kishta Reddy, Jian Chen, Glenn D. Prestwich, John Russell Falck, Stephen B. Shears, Eileen M. Lafer · 1997 · Journal of Biological Chemistry
- Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cellsJing YANG, James F. CLARKE, Catriona J. ESTER, Paul William Young, Masato Kasuga, Geoffrey David Holman · 1996 · Biochemical Journal
- Phosphoinositide 3-kinase activation and platelet functionS E Rittenhouse · 1996 · Blood
- Insulin Regulation of Membrane-associated Insulin Receptor Substrate 1Robin A. Heller-Harrison, Michelle Morin, Michael Czech · 1995 · Journal of Biological Chemistry
- Specific Association of the β Isoform of the p85 Subunit of Phosphatidylinositol-3 Kinase with the Proto-oncogene c-cblDavid Hartley, Herman M. Meisner, Silvia Corvera · 1995 · Journal of Biological Chemistry
- Insulin action in cultured human myoblasts: contribution of different signalling pathways to regulation of glycogen synthesisSteven J. Hurel, Justin J. Rochford, Andrew C. Borthwick, Anne M. WELLS, Jackie R. Vandenheede, Douglass M. Turnbull, Stephen J. Yeaman · 1996 · Biochemical Journal
- Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinaseJean‐François Tanti, Thierry Grémeaux, Emmanuel VAN OBBERGHEN, Yannick LE MARCHAND‐BRUSTEL · 1994 · Biochemical Journal
- Different Effects of Insulin and Platelet‐Derived Growth Factor on Phosphatidylinositol 3‐Kinase at the Subcellular Level in 3T3‐L1 AdipocytesJean‐Marc Ricort, Jean‐François Tanti, Emmanuel VAN OBBERGHEN, Yannick LE MARCHAND‐BRUSTEL · 1996 · European Journal of Biochemistry
- Both rapamycin-sensitive and -insensitive pathways are involved in the phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in response to insulin in rat epididymal fat-cellsTricia A. Diggle, S. Kelly MOULE, Matthew B. Avison, Andrea Flynn, Emily J. FOULSTONE, Christopher G. Proud, Richard M. Denton · 1996 · Biochemical Journal
- YMXM Motifs and Signaling by an Insulin Receptor Substrate 1 Molecule without Tyrosine Phosphorylation SitesMartin Grosvenor Myers, Yitao Zhang, Gladys A. I. Aldaz, Timothy C. Grammer, Erin M. Glasheen, Lynne Yenush, Ling Mei Wang, Xiao‐Jian Sun, John Blenis, Jacalyn H. Pierce et al. · 1996 · Molecular and Cellular Biology
- Phosphatidylinositol 3-kinase binds to α-actinin through the p85 subunitFutoshi Shibasaki, Kiyoko Fukami, Yoshinori Fukui, T Takenawa · 1994 · Biochemical Journal
- Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP.Patricia A. Staubs, Donna R. Reichart, Alan R. Saltiel, Kim L. Milarski, Hiroshi Maegawa, Paulos Berhanu, Jerrold M. Olefsky, B. Lynn Seely · 1994 · Journal of Biological Chemistry
- Protein Kinase B and Rac Are Activated in Parallel within a Phosphatidylinositide 3OH-kinase-controlled Signaling PathwayHeidi C. E. Welch, A. Eguinoa, Leonard R. Stephens, Phillip T. Hawkins · 1998 · Journal of Biological Chemistry
- Distinct Modes of Interaction of SHC and Insulin Receptor Substrate-1 with the Insulin Receptor NPEY Region via Non-SH2 DomainsWeimin He, Thomas J. O’Neill, Thomas A. Gustafson · 1995 · Journal of Biological Chemistry
- cAMP Counter-regulates Insulin-mediated Protein Phosphatase-2A Inactivation in Rat Skeletal Muscle CellsNajma Begum, Louis Ragolia · 1996 · Journal of Biological Chemistry
- Activation of protein kinase C alpha inhibits insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1.J.E. Chin, Fang Liu, Robert A. Roth · 1994 · Molecular Endocrinology
- Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cellsYannick LE MARCHAND‐BRUSTEL, Nadine Gautier, Mireille Cormont, Emmanuel VAN OBBERGHEN · 1995 · Endocrinology
- Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II.Milenko J. Tanasijevic, Martin Grosvenor Myers, Richard S. Thoma, Dan L. Crimmins, Morris F. White, David B. Sacks · 1993 · Journal of Biological Chemistry
- The 60 kDa Insulin Receptor Substrate Functions Like an IRS Protein (pp60IRS3) in Adipose CellsJennifer Smith-Hall, Sebastián Pons, Mary‐Elizabeth Patti, Deborah Jane Burks, Lynne Yenush, Xiao‐Jian Sun, C. Ronald Kahn, Morris F. White · 1997 · Biochemistry
- Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells.Rachel Levy-Toledano, Mohammed Taouis, Derek H. Blaettler, Phillip Görden, Simeon I. Taylor · 1994 · Journal of Biological Chemistry
- A Target of Phosphatidylinositol 3,4,5‐Trisphosphate with a Zinc Finger Motif Similar to that of the ADP‐Ribosylation‐Factor GTPase‐Activating Protein and Two Pleckstrin Homology DomainsKenichi Tanaka, Shinobu Imajoh‐Ohmi, Takayuki Sawada, Ryuichi Shirai, Yuichi Hashimoto, Shigeo Iwasaki, Kouzou Kaibuchi, Yasunori Kanaho, Toshiyuki Shirai, Yoh Terada et al. · 1997 · European Journal of Biochemistry
- Inositol lipid 5-phosphatases-traffic signals and signal trafficRüdiger Woscholski, Peter J. Parker · 1997 · Trends in Biochemical Sciences
- Characterization of a 60-kilodalton substrate of the insulin receptor kinaseYoichi Hosomi, Kozui Shii, Wataru Ogawa, H. Matsuba, Masaki Yoshida, Y Okada, Koichi Yokono, Masato Kasuga, Satoshi Baba, Richard A. Roth · 1994 · Journal of Biological Chemistry
- Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columnsMichael Fry, George Panayotou, Ritu Dhand, Fernanda Ruiz‐Larrea, Ivan T. Gout, O Nguyen, Sara A. Courtneidge, Michael Derek Waterfield · 1992 · Biochemical Journal
- Phosphatidylinositol 3,4,5‐trisphosphate is a substrate for the 75 kDa inositol polyphosphate 5‐phosphatase and a novel 5‐phosphatase which forms a complex with the p85/p110 form of phosphoinositide 3‐kinase.Shaun P. Jackson, Simone M. Schoenwaelder, Maria Matzaris, S. Brown, Christina Anne Mitchell · 1995 · The EMBO Journal
- Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85β protein by using the baculovirus expression systemIvan T. Gout, Ritu Dhand, George Panayotou, Michael Fry, I. Hiles, M Otsu, Michael Derek Waterfield · 1992 · Biochemical Journal
- Ras-independent and Wortmannin-sensitive Activation of Glycogen Synthase by Insulin in Chinese Hamster Ovary CellsHiroshi Sakaue, Kenta Hara, Tetsuya Noguchi, Takashi Matozaki, Kei Kotani, Wataru Ogawa, Kazuyoshi Yonezawa, Masato Kasuga, Michael Derek Waterfield · 1995 · Journal of Biological Chemistry
- Inhibitors of Phosphoinositide 3-Kinase Block Exocytosis but Not Endocytosis of Transferrin Receptors in 3T3-L1 AdipocytesPeter Robin Shepherd, Maria A. Soos, Kenneth Siddle · 1995 · Biochemical and Biophysical Research Communications
- Expression, Enzyme Activity, and Subcellular Localization of Mammalian Target of Rapamycin in Insulin-Responsive CellsDominic J. Withers, D. Margriet Ouwens, BARBARA T. NAVÉ, Gerard C.M. van der Zon, Clara M. Alarcón, Maria Elena Cardenas, Joseph Heitman, J. Antonie Maassen, Peter Robin Shepherd · 1997 · Biochemical and Biophysical Research Communications
- Specific Activation of p85-p110 Phosphatidylinositol 3′-Kinase Stimulates DNA Synthesis by ras- and p70 S6 Kinase-Dependent PathwaysJames McIlroy, Daxin Chen, Christina Wjasow, Tamar Michaeli, Jonathan Backer · 1997 · Molecular and Cellular Biology
- Signaling Pathway Involved in the Activation of Heart 6-Phosphofructo-2-kinase by InsulinVáronique Lefebvre, Marie-Claire Máchin, Marc P. Louckx, Mark H. Rider, Louis Hue · 1996 · Journal of Biological Chemistry
- Cloning of a Novel, Ubiquitously Expressed Human Phosphatidylinositol 3-Kinase and Identification of Its Binding Site on p85Patrick J Hu, Anna Mondino, Edward Y. Skolnik · 1993 · Molecular and Cellular Biology
- 14-3-3β Protein Associates with Insulin Receptor Substrate 1 and Decreases Insulin-stimulated Phosphatidylinositol 3′-Kinase Activity in 3T3L1 AdipocytesAtsushi Kosaki, Kazunori D. Yamada, Junko Suga, Akira Otaka, Hideshi Kuzuya · 1998 · Journal of Biological Chemistry
- Requirement of Phosphatidylinositol-3 Kinase for Activation of JNK/SAPKs by PDGFMarco A. Lopez-Ilasaca, Weiqun Li, Aykut Üren, Jin‐Chen Yu, Andrius Kazlauskas, Jorge Silvio Gutkind, Mohammad A. Heidaran · 1997 · Biochemical and Biophysical Research Communications
- Insulin treatment stimulates the tyrosine phosphorylation of the alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase in vivo.Hideki Hayashi, Seika Kamohara, Yasuhiko Nishioka, Fumihiko Kanai, Naoki Miyake, Yoshinori Fukui, Futoshi Shibasaki, T Takenawa, Y Ebina · 1992 · Journal of Biological Chemistry
- Localization of the Insulin-like Growth Factor I Receptor Binding Sites for the SH2 Domain Proteins p85, Syp, and GTPase Activating ProteinB. Lynn Seely, Donna R. Reichart, Patricia A. Staubs, Byung Hak Jhun, David S. Hsu, Hiroshi Maegawa, Kim L. Milarski, Alan R. Saltiel, Jerrold M. Olefsky · 1995 · Journal of Biological Chemistry
- Identification of a Common Amino Acid Polymorphism in the p85α Regulatory Subunit of Phosphatidylinositol 3-Kinase: Effects on Glucose Disappearance Constant, Glucose Effectiveness, and the Insulin Sensitivity IndexTorben F. Hansen, Carsten Andersen, Søren M. Echwald, Søren A. Urhammer, Jesper O. Clausen, Henrik Vestergaard, David R. Owens, Lars Hansen, Oluf Borbye Pedersen · 1997 · Diabetes
- The alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor.Hideki Hayashi, Yasuhiko Nishioka, Seika Kamohara, Fumihiko Kanai, K. Ishii, Yoshinori Fukui, Futoshi Shibasaki, T Takenawa, Hiroshi Kido, NOBUHIKO KATSUNUMA · 1993 · Journal of Biological Chemistry
- Differential Regulation of Phosphoinositide 3-Kinase Adapter Subunit Variants by Insulin in Human Skeletal MusclePeter Robin Shepherd, BARBARA T. NAVÉ, Jorge Rincón, Lorraine A. Nolte, A. Paul Bevan, Kenneth Siddle, Juleen Rae Zierath, Harriet Wallberg‐Henriksson · 1997 · Journal of Biological Chemistry
- Association of phosphorylated insulin-like growth factor-I receptor with the SH2 domains of phosphatidylinositol 3-kinase p85.Kazutoshi Yamamoto, Daniel L. Altschuler, Edgar R. Wood, K Horlick, Steven Jacobs, E G Lapetina · 1992 · Journal of Biological Chemistry
- Identification of the Site in the cGMP-inhibited Phosphodiesterase Phosphorylated in Adipocytes in Response to Insulin and IsoproterenolTova Rahn Landström, Lars Rönnstrand, M Leroy, Christer Wernstedt, Hans E. Tornqvist, Vincent C. Manganiello, Per Belfrage, Eva Degerman · 1996 · Journal of Biological Chemistry
- The role of phosphoinositide 3-kinase in insulin signallingPeter Robin Shepherd, BARBARA T. NAVÉ, Stephen O’Rahilly · 1996 · Journal of Molecular Endocrinology
- Insulin Stimulates Guanine Nucleotide Exchange on Rab4 via a Wortmannin-sensitive Signaling Pathway in Rat AdipocytesHiroshi Shibata, Waka Omata, Itaru Kojima · 1997 · Journal of Biological Chemistry
- Liver Microsomal Glucose-6-phosphatase Is Competitively Inhibited by the Lipid Products of Phosphatidylinositol 3-KinaseGilles Mithieux, Nathalie Danièle, Bernard Payrastre, Carine Zitoun · 1998 · Journal of Biological Chemistry
- The v-Src SH3 Domain Binds Phosphatidylinositol 3'-KinaseXingquan Liu, Luc E. M. Marengère, Christine Anne Koch · 1993 · Molecular and Cellular Biology
- cDNA cloning of porcine p42IP4, a membrane‐associated and cytosolic 42 kDa inositol(1,3,4,5)tetrakisphosphate receptor from pig brain with similarly high affinity for phosphatidylinositol (3,4,5)P3Rolf Stricker, E Hülser, J Fischer, Thomas Jarchau, Ulrich Walter, Friedrich Lottspeich, Georg Reiser · 1997 · FEBS Letters
- Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylationYutaka Yatomi, Osamu Hazeki, S Kume, M Ui · 1992 · Biochemical Journal
- A Novel, Rapid, and Highly Sensitive Mass Assay for Phosphatidylinositol 3,4,5-Trisphosphate (PtdIns(3,4,5)P3) and Its Application to Measure Insulin-stimulated PtdIns(3,4,5)P3 Production in Rat Skeletal Muscle in VivoJeroen VAN DER KAAY, Ian H. Batty, Darren A.E. Cross, P. Watt, C. Peter Downes · 1997 · Journal of Biological Chemistry
- Potent Activation of Phosphatidylinositol 3'-Kinase by Simple Phosphotyrosine Peptides Derived from Insulin Receptor Substrate 1 Containing Two YMXM Motifs for binding SH2 DomainsJohn J. Herbst, Glenn C. Andrews, Leonard G. Contillo, Lou Lamphere, Joseph P. Gardner, Gustav E. Lienhard, E. Michael Gibbs · 1994 · Biochemistry
- Selective Inhibition of p70 S6 Kinase Activation by Phosphatidylinositol 3-Kinase InhibitorsClaudia Katharina Petritsch, Rüdiger Woscholski, Helga M. L. Edelmann, Peter J. Parker, Lisa M. Ballou · 1995 · European Journal of Biochemistry
- Phosphorylation of cbl after Stimulation of Nb2 Cells with Prolactin and Its Association with Phosphatidylinositol 3-KinaseSeija Hunter, Becky L. Koch, Steven Michael Anderson · 1997 · Molecular Endocrinology
- Identification by mutation of the tyrosine residues in the insulin receptor substrate-1 affecting association with the tyrosine phosphatase 2C and phosphatidylinositol 3-kinaseStéphane Rocchi, Sophie Tartare‐Deckert, Isabelle Mothe‐Satney, Emmanuel VAN OBBERGHEN · 1995 · Endocrinology
- Regulation by insulin of phosphatidylinositol 3'-kinase bound to alpha- and beta-isoforms of p85 regulatory subunit.Kurt Baltensperger, Lynn M. Kozma, Stephen R. Jaspers, Michael P. Czech · 1994 · Journal of Biological Chemistry
- Role of Serine/Threonine Protein Phosphatases in Insulin Regulation of Na+/K+-ATPase Activity in Cultured Rat Skeletal Muscle CellsLouis Ragolia, Basil Cherpalis, Malathi Srinivasan, Najma Begum · 1997 · Journal of Biological Chemistry
- Selective Recognition of Phosphatidylinositol 3,4,5-Trisphosphate by a Synthetic PeptidePei‐Jung Lu, Ching‐Shih Chen · 1997 · Journal of Biological Chemistry
- Differential Activation of Mitogen-Activated Protein Kinase by Insulin and Epidermal Growth Factor in 3T3-L1 Adipocytes: A Possible Involvement of PI3-Kinase in the Activation of the MAP Kinase by InsulinJunko Suga, Yasunao Yoshimasa, Kazunori D. Yamada, Yuji Yamamoto, Gen Inoue, Motozumi Okamoto, Tatsuya Hayashi, Michika Shigemoto, Atsushi Kosaki, Hideshi Kuzuya et al. · 1997 · Diabetes
- Phosphatidylinositol 3′-kinase, But Not p70 Ribosomal S6 Kinase, Is Involved in Membrane Protein Recycling: Wortmannin Inhibits Glucose Transport and Downregulates Cell-Surface Transferrin Receptor Numbers Independently of Any Effect on Fluid-phase Endocytosis in FibroblastsThomas J. Jess, Christopher M. BELHAM, FIONA J. THOMSON, Pamela Scott, Robin J. Plevin, Gwyn W. Gould · 1996 · Cellular Signalling
- In vitro association of phosphatidylinositol 3-kinase activity with the activated insulin receptor tyrosine kinase.Kazuyoshi Yonezawa, Koichi Yokono, Kozui Shii, Wataru Ogawa, Akifumi Ando, Kenta Hara, Satoshi Baba, Yasushi Kaburagi, Ritsuko Yamamoto‐Honda, Kaoru Momomura · 1992 · Journal of Biological Chemistry
- Inhibition of Phosphatidylinositol 3-Kinase by c-Abl in the Genotoxic Stress ResponseZhi-Min Yuan, Taiju Utsugisawa, Yinyin Huang, Takatoshi Ishiko, Shuji Nakada, Surender M. Kharbanda, Ralph R. Weichselbaum, Donald W. Kufe · 1997 · Journal of Biological Chemistry
- Rab4, But Not the Transferrin Receptor, Is Colocalized with GLUT4 in an Insulin-Sensitive Intracellular Compartment in Rat Skeletal MuscleJuan Carlos Aledo, Froogh Darakhshan, Harinder S. Hundal · 1995 · Biochemical and Biophysical Research Communications
- The insulin receptor substrate-1-related 4PS substrate but not the interleukin-2R gamma chain is involved in interleukin-13-mediated signal transductionLM Wang, P Michieli, Wen‐Rong Lie, F Liu, Chien‐Chung Lee, Adrian J. Minty, XJ Sun, A Levine, Morris F. White, JH Pierce · 1995 · Blood
- cis-acting sequences involved in exon selection in the chicken beta-tropomyosin gene.Maria Eugenia Gallego, Laurent Balvay, Edward N. Brody · 1992 · Molecular and Cellular Biology
- Regulation of Phosphatidylinositol 3,4,5-Trisphosphate 5′-Phosphatase Activity by InsulinAdı́lson Guilherme, Jes K. Klarlund, Gerald Krystal, Michael Czech · 1996 · Journal of Biological Chemistry
- Binding to the Platelet-derived Growth Factor Receptor Transiently Activates the p85α-p110α Phosphoinositide 3-Kinase Complex in VivoJan Domin, Ritu Dhand, Michael Derek Waterfield · 1996 · Journal of Biological Chemistry
- ATP citrate-lyase and glycogen synthase kinase-3β in 3T3-L1 cells during differentiation into adipocytesW B Benjamin, Srinivas Pentyala, James Robert Woodgett, Y Hod, Daniel R. Marshak · 1994 · Biochemical Journal
- Insulin induces a change in Rab5 subcellular localization in adipocytes independently of phosphatidylinositol 3-kinase activationMireille Cormont, Emmanuel VAN OBBERGHEN, Marino Zerial, Yannick LE MARCHAND‐BRUSTEL · 1996 · Endocrinology
- Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cellsIan H. Batty, C. Peter Downes · 1996 · Biochemical Journal
- Characterization of the bovine brain cytosolic phosphatidylinositol 3-kinase complexFernanda Ruiz‐Larrea, Patricia Vicendo, Pnina Yaish, Peter End, George Panayotou, Michael Fry, Sarah J. Morgan, A Thompson, Peter J. Parker, Michael Derek Waterfield · 1993 · Biochemical Journal
- Disruption of GLUT1 glucose carrier trafficking in L6E9 and Sol8 myoblasts by the phosphatidylinositol 3-kinase inhibitor wortmanninPerla Kaliman, Francesc Viñals, Xavier Testar, Manuel Palacı́n, António Zorzano · 1995 · Biochemical Journal
- Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor to insulin receptor substrate 1Víctor Sánchez‐Margalet, Ira D. Goldfine, K. E. Truitt, John B. Imboden, Chin K. Sung · 1995 · Molecular Endocrinology
- The PI3-Kinase Serine Kinase Phosphorylates Its p85 Subunit and IRS-1 in PI3-Kinase/IRS-1 ComplexesGregory G. Freund, Johannes G. Wittig, Robert A. Mooney · 1995 · Biochemical and Biophysical Research Communications
- Functional Interactions of Phosphatidylinositol 3-Kinase with GTPase-Activating Protein in 3T3-L1 AdipocytesDavid DePaolo, Jane E.B. Reusch, Kirstin D. Carel, Penpun Bhuripanyo, J. Wayne Leitner, Boris Draznin · 1996 · Molecular and Cellular Biology
- Interactions Between SH2 Domains and Tyrosine-Phosphorylated Platelet-Derived Growth Factor β-receptor Sequences: Analysis of Kinetic Parameters by a Novel Biosensor-Based ApproachGeorge Panayotou, Gerry Gish, Peter End · 1993 · Molecular and Cellular Biology
- Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transportBARBARA T. NAVÉ, Kenneth Siddle, Peter Robin Shepherd · 1996 · Biochemical Journal
- Tyrosine 508 of the 85-Kilodalton Subunit of Phosphatidylinositol 3-Kinase Is Phosphorylated by the Platelet-Derived Growth Factor ReceptorW. Michael Kavanaugh, Christoph W. Turck, Anke Klippel, Lewis T. Williams · 1994 · Biochemistry
- Insulin-like growth factor-1-mediated association of p85 phosphatidylinositol 3-kinase with pp 185: requirement of SH2 domains for in vivo interaction.Daniel L. Altschuler, Kazutoshi Yamamoto, E G Lapetina · 1994 · Molecular Endocrinology
- Microinjection of the SH2 Domain of the 85-Kilodalton Subunit of Phosphatidylinositol 3-Kinase Inhibits Insulin-Induced DNA Synthesis and c-fos ExpressionByung Hak Jhun, David W. Rose, B. Lynn Seely, Lucia E. Rameh, Lewis C. Cantley, Alan R. Saltiel, Jerrold M. Olefsky · 1994 · Molecular and Cellular Biology
- Mutant of Insulin Receptor Substrate-1 Incapable of Activating Phosphatidylinositol 3-Kinase Did Not Mediate Insulin-stimulated Maturation of Xenopus laevis OocytesRitsuko Yamamoto‐Honda, Zen‐ichiro Honda, Kohjiro Ueki, Kazuyuki Tobe, Yasushi Kaburagi, Yoshihiko Takahashi, Hiroyuki Tamemoto, Takeshi Suzuki, Kohji Itoh, Yasuo Akanuma et al. · 1996 · Journal of Biological Chemistry
- Involvement of phosphatidylinositol 3-kinase in stimulation of glucose transport by growth factors in 3T3-L1 adipocytes.Kevin M. Conricode · 1995 · PubMed
- Effect of Oxaloacetate and Phosphorylation on ATP-Citrate Lyase ActivitySrinivas Pentyala, William B. Benjamin · 1995 · Biochemistry
- Heterologous expression of rab4 reduces glucose transport and GLUT4 abundance at the cell surface in oocytesSílvia Mora, Ingrid Monden, António Zorzano, K. Keller · 1997 · Biochemical Journal
- Ligand-Independent GLUT4 Translocation Induced by Guanosine 5'-O-(3-Thiotriphosphate) Involves Tyrosine PhosphorylationTetsuro Haruta, Aaron J. Morris, Péter Vollenweider, James G. Nelson, David W. Rose, Michael Mueckler, Jerrold M. Olefsky · 1998 · Endocrinology
- Detection of a 60 kDa tyrosine-phosphorylated protein in insulin-stimulated hepatoma cells that associates with the SH2 domain of phosphatidylinositol 3-kinaseKim L. Milarski, Dan F. Lazar, Russell J. Wiese, Alan R. Saltiel · 1995 · Biochemical Journal
- Effect of glucagon on insulin receptor substrate‐1 (IRS‐1) phosphorylation and association with phosphatidylinositol 3‐kinase (PI 3‐kinase)Mário J.A. Saad, Luiz Guilherme C. Hartmann, Daniela Carvalho, César Alex de Oliveira Galoro, Sigisfredo Luís Brenelli, Carla Roberta de Oliveira Carvalho · 1995 · FEBS Letters
- Interaction of Wild Type and Dominant-Negative p55PIK Regulatory Subunit of Phosphatidylinositol 3-Kinase with Insulin-Like Growth Factor-1 Signaling ProteinsIsabelle Mothe‐Satney, Laurent Delahaye, Chantal Filloux, Sebastián Pons, Morris F. White, Emmanuel VAN OBBERGHEN · 1997 · Molecular Endocrinology
- A 60-kilodalton protein in rat hepatoma cells overexpressing insulin receptor was tyrosine phosphorylated and associated with Syp, phophatidylinositol 3-kinase, and Grb2 in an insulin-dependent mannerG Zhang-Sun, Chia‐Ping Huang Yang, Jean Viallet, Gen‐Sheng Feng, John J.M. Bergeron, Barry I. Posner · 1996 · Endocrinology
- Functional interactions between isolated SH2 domains and insulin/Ras signaling pathways of Xenopus oocytes: opposite effects of the carboxy- and amino-terminal SH2 domains of p85 PI 3-kinase.Pilar Aroca, Daruka Mahadevan, Eugenio Santos · 1996 · PubMed
- cis -Acting Sequences Involved in Exon Selection in the Chicken β-Tropomyosin GeneMaria Eugenia Gallego, Laurent Balvay, Edward N. Brody · 1992 · Molecular and Cellular Biology
- Insulin-induced Activation of Phosphatidylinositol (PI) 3-KinaseRachel Levy-Toledano, Derek H. Blaettler, William J. LaRochelle, Simeon I. Taylor · 1995 · Journal of Biological Chemistry
- Insulin Stimulates Protein Synthesis of Glycogen Synthase in Rat Hepatoma H4 Cells Associated with Acceleration of Translation Rate.Naoki Fujita, Kohei Kaku, MASASHI OKUBO, Yuji Nagasaka, TOSHIO KANEKO · 1996 · Endocrine Journal
- Association of the insulin receptor and phosphatidylinositol 3-kinase requires a third componentR Liu, James N. Livingston · 1994 · Biochemical Journal