The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Matrix metalloproteinases in cancer
Abstract
The extracellular matrix (ECM) holds cells together and maintains the three-dimensional structure of the body. It also plays critical roles in cell growth, differentiation, survival and motility. For a tumour cell to metastasize from the primary tumour to other organs, it must locally degrade ECM components that are the physical barriers for cell migration. The key enzymes responsible for ECM breakdown are matrix metalloproteinases (MMPs). To date, 23 MMP genes have been identified in humans and many are implicated in cancer. ECM degradation by MMPs not only enhances tumour invasion, but also affects tumour cell behaviour and leads to cancer progression. This review highlights recent developments with regard to the cellular and molecular mechanisms of MMPs that influence tumour cell growth, invasion and metastasis.
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Citations
Cites
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Bergers, G., Brekken, R., McMahon, G., Vu, T. H., Itoh, T., Tamaki, K., Tanzawa, K., Thorpe, P., Itohara, S., Werb, Z., et al. (2000) · Nature Cell Biology · doi:10.1038/35036374 · Cited by 2,797
Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.
Gomis-R¨th, F.-X., Maskos, K., Betz, M., Bergner, A., Huber, R., Suzuki, K., Yoshida, N., Nagase, H., Brew, K., Bourenkov, G. P., et al. (1997) · Nature · doi:10.1038/37995 · Cited by 619
Self-citation
Cited by
Zhao, H., Wang, L., Wei, R., Xiu, D., Tao, M., Ke, J., Liu, Y., Yang, J., & Hong, T. (2014) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12291 · Cited by 88
Downregulation of the RECK‐tumor and metastasis suppressor gene in glioma invasiveness
Corrẽa, T. C. S., Brohem, C. A., Winnischofer, S. M. B., da Silva Cardeal, L. B., Sasahara, R. M., Taboga, S. R., Sogayar, M. C., & Maria‐Engler, S. S. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20917 · Cited by 32
α-Actinin-4 drives invasiveness by regulating myosin IIB expression and myosin IIA localization
Barai, A., Mukherjee, A., Das, A., Saxena, N., & Sen, S. (2021) · Journal of Cell Science · doi:10.1242/jcs.258581 · Cited by 23
Metadata
- Authors
- Itoh, Y., & Nagase, H.
- Venue
- Essays in Biochemistry
- Publisher
- Portland Press Ltd.
- Published
- 2002-10-01
- Volume
- 38
- Pages
- 21-36
- ISSN
- 0071-1365 (ISSN-L)
- 1744-1358
- OpenAlex
- W146600679
- Cited by
- 309
- References
- 2
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Itoh, Y., & Nagase, H. (2002). Matrix metalloproteinases in cancer. Essays in Biochemistry. https://doi.org/10.1042/bse0380021
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
