53BP1: function and mechanisms of focal recruitment
Open accessAbstract
53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of 53BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.
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In human cells, MDC1, 53BP1, and BRCA1 are candidate functional Rad9 orthologues and may all be considered Rad9 orthologues.
“In human cells, the identity of the functional Rad9 orthologue is still debated: multiple candidates exist – i.e., MDC1 (mediator of DNA-damage checkpoint 1), 53BP1 (p53-binding protein 1) and BRCA1 (breast cancer 1 early-onset) – all characterized by the presence of tandem BRCT (BRCA1 C-terminal repeat) domains. Since these three proteins are involved in checkpoint signal transduction and each of”
From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [31]
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References 90 · Cited by 141
- Authors
- FitzGerald, J. E., Grenon, M., & Lowndes, N. F.
- Affiliations
- Ollscoil na Gaillimhe – University of Galway (IE)
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2009-07-22
- Volume
- 37
- Issue
- 4
- Pages
- 897-904
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W2107029023
- Cited by
- 141
- References
- 90
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 20 · 2012: 18
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- Locations
- Biochemical Society Transactions (publishedVersion)
- PubMed (publishedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc)
- Research Repository UCD (University College Dublin) (cc-by-nc)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- 53BP1, DNA damage response, DNA damage checkpoint, DNA repair, DNA damage foci, histone modifications, p53-binding protein
- MeSH terms
- Tumor Suppressor p53-Binding Protein 1, Animals, Chromosomal Proteins, Non-Histone, DNA Damage, DNA Repair, DNA-Binding Proteins, Histones, Humans, Models, Biological, Intracellular Signaling Peptides and Proteins
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