Hippocampal synaptic activity, pattern separation and episodic-like memory: implications for mouse models of Alzheimer's disease pathology
Abstract
The present review summarizes converging evidence from animal and human studies that an early target of amyloid pathology is synaptic activity in the DG (dentate gyrus)/CA3 network. We briefly review the computational significance of the DG/CA3 network in the encoding of episodic memory and present new evidence that the CA3/DG pattern of activation is compromised in a mouse model of amyloid pathology. In addition, we present a new behavioural method to test the prediction that amyloid-related synaptic pathology will disrupt the formation of an integrated episodic-like (what, where and when) memory in mice.
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Mossy fiber "detonator" synapses arising from DG granule cells strongly activate the CA3 region and are involved in a variety of neurological functions, including memory and spatial representations.
“Mossy fiber “detonator” synapses arising from DG granule cells strongly activate the CA3 region and are involved in a variety of neurological functions, including memory and spatial representations [6], [64].”
From Arf4 Determines Dentate Gyrus-Mediated Pattern Separation by Regulating Dendritic Spine Development (2012) · cites this paper as [64]
The preclinical period prior to the diagnosis of AD is characterized by deficits in a number of memory-related processes, including pattern separation.
“The preclinical period prior to the diagnosis of AD is characterized by deficits in a number of memory-related processes, including pattern separation [64], [67].”
From Arf4 Determines Dentate Gyrus-Mediated Pattern Separation by Regulating Dendritic Spine Development (2012) · cites this paper as [64]
Cites
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Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus
Leutgeb, J. K., Leutgeb, S., Moser, M.-B., & Moser, E. I. (2007) · Science · doi:10.1126/science.1135801 · Cited by 1,601 · see citing works
Episodic-like memory during cache recovery by scrub jays
Clayton, N. S., & Dickinson, A. (1998) · Nature · doi:10.1038/26216 · Cited by 1,464 · see citing works
Hippocampal synaptic enhancement and information storage within a distributed memory system
McNaughton, B. L., & Morris, R. G. M. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90011-7 · Cited by 1,304 · see citing works
Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI
Kerchner, G. A., Hess, C. P., Hammond-Rosenbluth, K. E., Xu, D., Rabinovici, G. D., Kelley, D. A. C., Vigneron, D. B., Nelson, S. J., & Miller, B. L. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f736a1 · Cited by 193 · see citing works
Alzheimer's disease amyloid β-protein and synaptic function
Ondrejcak, T., Klyubin, I., Hu, N.-W., Barry, A. E., Cullen, W. K., & Rowan, M. J. (2010) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8091-0 · Cited by 146 · see citing works
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Arf4 Determines Dentate Gyrus-Mediated Pattern Separation by Regulating Dendritic Spine Development
Jain, S., Yoon, S. Y., Zhu, L., Brodbeck, J., Dai, J., Walker, D., & Huang, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046340 · Cited by 43 · see citing works
- Authors
- Palmer, A., & Good, M.
- Affiliations
- Cardiff University (GB)
- ORCID
- Good, Mark
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2011-07-20
- Volume
- 39
- Issue
- 4
- Pages
- 902-909
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W2137487902
- Cited by
- 34
- References
- 6
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 2 · 2012: 4
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Society Transactions (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, synaptic activity, pattern separation, episodic-like memory, Alzheimer's disease, amyloid pathology, dentate gyrus, CA3, episodic memory encoding, mouse model
- MeSH terms
- Alzheimer Disease, Animals, Disease Models, Animal, Hippocampus, Humans, Mice, Transgenic, Synaptic Transmission, Mental Recall, Amyloid beta-Peptides, Mice
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