Renal and cardiovascular effects of caffeine: a dose-response study
Abstract
The effects of increasing oral doses of caffeine (45, 90, 180 and 360 mg) on effective renal plasma flow (ERPF), plasma renin activity (PRA), serum electrolytes, plasma noradrenaline, blood pressure and heart rate were studied in eight healthy male volunteers. Urine volume was increased by 360 mg of caffeine only. At caffeine doses greater than 90 mg urinary sodium excretion was significantly increased. There were no changes in ERPF. Serum potassium was significantly reduced by 360 mg of caffeine. Caffeine increased systolic pressure in a dose related manner. Diastolic pressure was also increased, but not in relation to dose. A 360 mg dose of caffeine produced a late increase in heart rate. These changes were not associated with any alterations in PRA or in plasma noradrenaline.
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These opinions and advisories are based upon a relatively small collection of caffeine studies.
“These opinions and advisories are based upon a relatively small collection of caffeine studies that have been publicised in both scientific and lay literature and in the media over the past few decades [10], [17], [25].”
From No Evidence of Dehydration with Moderate Daily Coffee Intake: A Counterbalanced Cross-Over Study in a Free-Living Population (2014) · cites this paper as [17]
Caffeine has a diuretic effect.
“Caffeine has a diuretic effect (123, 162, 163).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [162]
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References 26 · Cited by 107
- Authors
- Passmore, A. P., Kondowe, G. B., & Johnston, G. D.
- Affiliations
- Queen's University Belfast (GB)
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 1987-06-01
- Volume
- 72
- Issue
- 6
- Pages
- 749-756
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W2262017234
- Cited by
- 107
- References
- 26
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 8 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 2 · 2014: 6 · 2013: 4 · 2012: 3
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Science (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- caffeine, dose-response relationship, renal plasma flow, plasma renin activity, serum electrolytes, sodium excretion, serum potassium, plasma norepinephrine, blood pressure, heart rate, cardiovascular effects, renal effects
- MeSH terms
- Adult, Blood Pressure, Caffeine, Dose-Response Relationship, Drug, Heart, Heart Rate, Humans, Kidney, Male, Norepinephrine, Potassium, Renal Circulation, Renin, Sodium
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