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Cited by 21Helicobacter pylori-related gastroenterology studiesHepatitis C virus researchGastrointestinal motility and disorders

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Beta‐lactamase inhibitor enhances Helicobacter pylori eradication rate

Ojetti, V., Migneco, A., Zocco, M. A., Nista, E. C., Gasbarrini, G., Gasbarrini, A.·2004·Journal of Internal Medicine
DOI 10.1046/j.0954-6820.2003.01239.x
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Abstract

OBJECTIVES: One-week triple therapy, a combination of acid suppression with two antibiotics, is the gold standard for anti-Helicobacter pylori treatment. There is increasing evidence of H. pylori resistance to classical triple therapy. Recently, it was reported that the amoxicillin-clavulanate combination had a slightly higher activity than amoxicillin alone against H. pylori, and that beta-lactamase inhibitors had 'in-vitro' antibacterial activity against H. pylori. SETTING: To evaluate the efficacy of 1 week triple therapy omeprazole, clarithromycin and amoxicillin plus clavulanate compared with omeprazole, clarithromycin and amoxicillin for H. pylori eradication. The study was open randomized. SUBJECTS: Sixty dyspeptic patients (36 male, 24 female; mean age 53 +/- 9 years) with Helicobacter pylori infection never treated before, were enrolled and randomly assigned to two different 7-day triple therapies: (i) (n = 30) amoxicillin 875 mg plus clavulanic acid 125 mg b.i.d., clarithromycin 500 mg b.i.d., omeprazole 20 mg b.i.d. (ACCO); (ii) (n = 30) amoxicillin 1 g b.i.d., clarithromycin 500 mg b.i.d., omeprazole 20 mg b.i.d. (ACO). Bacterial eradication was assessed by 13C-urea breath test 4-6 weeks after therapy. Information on gastrointestinal symptoms and antibiotic-related side-effects were recorded using a questionnaire. RESULTS: All patients completed the study. A significantly higher H. pylori eradication rate with ACCO compared with ACO: (26/30) 86.6 vs. (20/30) 66.6%, respectively (P < 0.05) were observed. No major side-effects were reported, whilst 8% patients complained of mild side-effects; no significant differences were noted between the two groups. CONCLUSIONS: Our results suggest that amoxicillin and clavulanate in combination achieve a higher H. pylori eradication rate than amoxicillin alone, without any increase in side-effects. The combination of amoxicillin and clavulanate may represent an alternative therapeutic scheme for the treatment of H. pylori infection.

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Crossref · 10.1046/j.0954-6820.2003.01239.x

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Metadata

Authors
Ojetti, V., Migneco, A., Zocco, M. A., Nista, E. C., Gasbarrini, G., & Gasbarrini, A.
Affiliations
Agostino Gemelli University Polyclinic (IT)
ORCID
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2003-12-18
Volume
255
Issue
1
Pages
125-129
ISSN
  • 0954-6820 (ISSN-L)
  • 1365-2796
DOI
10.1046/j.0954-6820.2003.01239.x
OpenAlex
W1997839897
Cited by
21
References
37
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2014: 1 · 2013: 1
FWCI
1.60
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
Helicobacter pylori, triple therapy, beta-lactamase inhibitors, clavulanic acid, amoxicillin, clarithromycin, omeprazole, Helicobacter pylori eradication, dyspepsia, antibiotic resistance, 13C-urea breath test
MeSH terms
beta-Lactamases, Drug Therapy, Combination, Dyspepsia, Enzyme Inhibitors, Female, Humans, Male, Middle Aged, Omeprazole, Patient Compliance, Helicobacter pylori, Helicobacter Infections, Clarithromycin, Amoxicillin-Potassium Clavulanate Combination, beta-Lactamase Inhibitors

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