The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
The red blood cell as an oxygen sensor: what is the evidence?
Abstract
The matching of oxygen supply with demand requires the existence of a mechanism within the tissue capable of both sensing tissue oxygen need and inducing alterations in vascular perfusion necessary to meet that need. Historically, localized sites within the tissue and the vessels themselves have been investigated with the sensor site failing to be determined. Within the last decade, studies have focused on the red blood cell, the efficient carrier of oxygen, as a possible candidate. The red blood cell is clearly capable of sensing oxygen levels, as its extent of haemoglobin desaturation (decrease in oxygen content) is intimately tied with tissue oxygen demand. In addition, numerous studies have indicated that the red blood cell is capable of releasing increased amounts of adenosine 5′‐triphosphate (ATP) as oxygen content falls and its haemoglobin becomes desaturated. Within the vasculature, intraluminal ATP has been shown to induce a vasodilator response which is conducted along the vessels resulting in augmentation of tissue perfusion. While details of the red blood cell’s role are still under investigation, evidence presented here supports the intriguing idea that the mobile red blood cell may itself be able to augment blood flow and oxygen delivery wherever and whenever the need might arise. Such a mechanism eliminates the requirement for a diverse network of sensing sites throughout the vasculature and should provide a more efficient means of appropriately matching oxygen supply with demand.
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“There is consensus in the field that NO-erythrocytic interactions regulate vascular function, particularly that oxygen desaturation of red blood cell Hb stimulates increased vascular NO bioavailability, leading to NO-dependent hypoxic vasodilation (266).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [266]
Citations
Cites
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Blood Flow Regulation by S -Nitrosohemoglobin in the Physiological Oxygen Gradient
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In vivo measurements of “apparent viscosity” and microvessel hematocrit in the mesentery of the cat
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Gap Junctions in Vascular Tissues
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Cellular Distribution and Functions of P2 Receptor Subtypes in Different Systems
Burnstock, G., & Knight, G. E. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)40002-3 · Cited by 796
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body
Kumar, P., & Prabhakar, N. R. (2012) · Comprehensive physiology · doi:10.1002/cphy.c100069 · Cited by 581
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
Huang, Z. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24650 · Cited by 520
Jensen, F. B. (2004) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2004.01361.x · Cited by 346
Metadata
- Authors
- Ellsworth, M. L.
- Affiliations
- Saint Louis University (US)
- Corresponding author
- Ellsworth, M.L.
- Venue
- Acta Physiologica Scandinavica
- Publisher
- Wiley
- Published
- 2000-04
- Volume
- 168
- Issue
- 4
- Pages
- 551-559
- ISSN
- 0001-6772 (ISSN-L)
- 1365-201X
- OpenAlex
- W1984179683
- Cited by
- 186
- References
- 32
- Citations by year
- 2026: 4 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 8 · 2019: 2 · 2018: 6 · 2017: 9 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 13 · 2012: 12
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Physiologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k04hl002602-03)
- National Heart, Lung, and Blood Institute (R01HL056249, HL56249, HL 39226, HL-02602)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
- Keywords
- tissue oxygen demand, ATP release, vasodilation, tissue perfusion, oxygen delivery
- MeSH terms
- Adenosine Triphosphate, Animals, Erythrocytes, Humans, Oxygen, Oxygen Consumption, Regional Blood Flow, Muscle, Skeletal
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