The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Mitogen‐activated protein kinase signal transduction in skeletal muscle: effects of exercise and muscle contraction
Abstract
Exercise has numerous growth and metabolic effects in skeletal muscle, including changes in glycogen metabolism, glucose and amino acid uptake, protein synthesis and gene transcription. However, the mechanism(s) by which exercise regulates intracellular signal transduction to the transcriptional machinery in the nucleus, thus modulating gene expression, is largely unknown. This review will provide insight on potential intracellular signalling mechanisms by which muscle contraction/exercise leads to changes in gene expression. Mitogen‐activated protein kinase (MAPK) cascades are associated with increased transcriptional activity. The MAPK family members can be separated into distinct parallel pathways including the extracellular signal‐regulated kinase (ERK) 1/2, the stress‐activated protein kinase cascades (SAPK1/JNK and SAPK2/p38) and the extracellular signal‐regulated kinase 5 (ERK5). Acute exercise elicits signal transduction via MAPK cascades in direct response to muscle contraction. Thus, MAPK pathways appear to be potential physiological mechanisms involved in the exercise‐induced regulation of gene expression in skeletal muscle.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diet, muscle glycogen and physical performance.
Bergström, J., Hermansen, L., Hultman, E., & Saltin, B. (1967) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1967.tb03720.x · Cited by 1,740
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
Schlaepfer, D. D., Hanks, S. K., Hunter, T., & Geer, P. V. D. (1994) · Nature · doi:10.1038/372786a0 · Cited by 1,595
Nuclear protein CBP is a coactivator for the transcription factor CREB
Kwok, R. P. S., Lundblad, J. R., Chrivia, J. C., Richards, J. P., Bächinger, H. P., Brennan, R. G., Roberts, S. G. E., Green, M. R., & Goodman, R. H. (1994) · Nature · doi:10.1038/370223a0 · Cited by 1,443
Krook, A., Björnholm, M., Galuska, D., Jiang, X. J., Fahlman, R., Myers, M. G., Wallberg-Henriksson, H., & Zierath, J. R. (2000) · Diabetes · doi:10.2337/diabetes.49.2.284 · Cited by 375
Self-citationElevated skeletal muscle glucose transporter levels in exercise-trained middle-aged men
Houmard, J. A., Egan, P. C., Neufer, P. D., Friedman, J. E., Wheeler, W. S., Israel, R. G., & Dohm, G. L. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.261.4.e437 · Cited by 158
Cited by
Little, J. P., Safdar, A., Bishop, D., Tarnopolsky, M. A., & Gibala, M. J. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00538.2010 · Cited by 342
Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans
Coffey, V. G., Zhong, Z., Shield, A., Canny, B. J., Chibalin, A. V., Zierath, J. R., & Hawley, J. A. (2006) · The FASEB Journal · doi:10.1096/fj.05-4809fje · Cited by 336
Self-citationAdaptations of Skeletal Muscle to Prolonged, Intense Endurance Training
Hawley, J. A. (2002) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2002.03623.x · Cited by 328
Invited Review: Intracellular signaling in contracting skeletal muscle
Sakamoto, K., & Goodyear, L. J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00167.2002 · Cited by 264
Nutritional modulation of training-induced skeletal muscle adaptations
Hawley, J. A., Burke, L. M., Phillips, S. M., & Spriet, L. L. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00949.2010 · Cited by 205
Metadata
- Authors
- Widegren, U., Ryder, J. W., & Zierath, J. R.
- Venue
- Acta Physiologica Scandinavica
- Publisher
- Wiley
- Published
- 2001-07-24
- Volume
- 172
- Issue
- 3
- Pages
- 227-238
- ISSN
- 0001-6772 (ISSN-L)
- 1365-201X
- OpenAlex
- W2034240213
- Cited by
- 174
- References
- 5
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mitogen‐activated protein kinase signal transduction in skeletal muscle: effects of exercise and muscle contraction. https://app.cochat.ai/papers/10.1046/j.1365-201x.2001.00855.x
- The paper
- Widegren, U., Ryder, J. W., & Zierath, J. R. (2001). Mitogen‐activated protein kinase signal transduction in skeletal muscle: effects of exercise and muscle contraction. Acta Physiologica Scandinavica. https://doi.org/10.1046/j.1365-201x.2001.00855.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
