The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Review article: cytochrome P450 and the metabolism of proton pump inhibitors — emphasis on rabeprazole
Open accessAbstract
The proton pump inhibitors rabeprazole, omeprazole, lansoprazole, and pantoprazole undergo an extensive hepatic biotransformation. In the liver, they are metabolized to varying degree by several cytochrome P450 (CYP) isoenzymes which are further categorized into subfamilies of related polymorphic gene products. The principal isoenzymes involved in the metabolism of proton pump inhibitors are CYP2C19 and CYP3A4. Of these two, minor mutations in CYP2C19 affect its activity in the liver and, in turn, the metabolic and pharmacokinetic profiles of the proton pump inhibitors. The metabolism of rabeprazole is less dependent on CYP2C19 and therefore is the least affected by this genetic polymorphism. Recent studies have brought to light the important role that this polymorphism plays in the therapeutic effectiveness of proton pump inhibitors during the treatment of acid‐related diseases.
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Cited by
Influence of Omeprazole on the Antiplatelet Action of Clopidogrel Associated With Aspirin
Gilard, M., Arnaud, B., Cornily, J.-C., Le Gal, G., Lacut, K., Le Calvez, G., Mansourati, J., Mottier, D., Abgrall, J.-F., & Boschat, J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.06.064 · Cited by 1,015
Polymorphism of human cytochrome P450 enzymes and its clinical impact
Zhou, S.-F., Liu, J.-P., & Chowbay, B. (2009) · Drug Metabolism Reviews · doi:10.1080/03602530902843483 · Cited by 826
for the SIF-AIGO-FIMMG Group, Scarpignato, C., on behalf of the Italian Society of Pharmacology, T. I. A. O. H. G., Gatta, L., Zullo, A., & Blandizzi, C. (2016) · BMC Medicine · doi:10.1186/s12916-016-0718-z · Cited by 469
Writing Committee Members, Abraham, N. S., Hlatky, M. A., Antman, E. M., Bhatt, D. L., Bjorkman, D. J., Clark, C. B., Furberg, C. D., Johnson, D. A., Kahi, C. J., et al. (2010) · Circulation · doi:10.1161/cir.0b013e318202f701 · Cited by 451
Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel
Siller-Matula, J. M., Spiel, A. O., Lang, I. M., Kreiner, G., Christ, G., & Jilma, B. (2009) · American Heart Journal · doi:10.1016/j.ahj.2008.09.017 · Cited by 397
Metadata
- Authors
- Ishizaki, & Horai
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 1999-08
- Volume
- 13
- Issue
- s3
- Pages
- 27-36
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2002929828
- Cited by
- 428
- References
- 38
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ishizaki, & Horai. (1999). Review article: cytochrome P450 and the metabolism of proton pump inhibitors — emphasis on rabeprazole. Alimentary Pharmacology & Therapeutics. https://doi.org/10.1046/j.1365-2036.1999.00022.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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