The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Natural history and epidemiology of Helicobacter pylori infection
Abstract
Helicobacter pylori is a common bacterium infecting about half the world's population. It is causally linked with a diverse spectrum of gastrointestinal clinical disorders including peptic ulcer disease, gastric cancer, and gastric MALT lymphoma. The principal reservoir is the human stomach, and transmission probably occurs by person‐to‐person passage. Prevalence rates are generally much higher in developing countries compared to developed countries, although there are subgroups within many regions with higher H. pylori prevalence than in the general population. The prevalence of H. pylori varies by geographical location, ethnic background, socioeconomic conditions, and age. Recent studies suggest decreasing prevalence in developed countries or those with rapidly improving socioeconomic conditions. Comparative studies of the two fully sequenced H. pylori genomes are providing understanding of its large genetic diversity and bacterial virulence factors. The discovery of the type IV secretion system in H. pylori and its role in translocation of the CagA protein from the bacterial cell into the host epithelial cell provides insight into how host–bacterial interaction may lead to host disease. Cytokine promoter polymorphisms are determinants important in host gastric acid secretion status. Understanding the changing trends in H. pylori epidemiology, details of its transmission pathways, and the bacterial and host determinants leading to gastroduodenal disease remain the challenges in this area. Global epidemiological studies, advances in technology, and medical interventions have converged to help clarify the mechanisms of interaction between this ubiquitous micro‐organism and its host that result in its diverse clinical manifestations.
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Cites
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Cited by
Helicobacter pylori and extragastric diseases: A review
Gravina, A. G., Zagari, R. M., Musis, C. D., Romano, L., Loguercio, C., & Romano, M. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i29.3204 · Cited by 328
Helicobacter in the developing world
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TONG, J. L., RAN, Z. H., SHEN, J., ZHANG, C. X., & XIAO, S. D. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03179.x · Cited by 258
Helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface
Tan, S., Noto, J. M., Romero-Gallo, J., Peek, R. M., & Amieva, M. R. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002050 · Cited by 175
Metadata
- Authors
- Go, M. F.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2002-03
- Volume
- 16
- Issue
- s1
- Pages
- 3-15
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W1997711745
- Cited by
- 440
- References
- 42
- FWCI
- 18.75
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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