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Clinical features of photodamaged human skin are associated with a reduction in collagen VII
Abstract
Chronically sun-exposed or photodamaged human skin is characterized by a number of clinical features, including wrinkles. However, little is known about the molecular mechanisms that underlie these features. We investigated the hypothesis that the mechanism of wrinkle formation may involve loss of anchoring fibrils, composed mainly of collagen VII, which are important in maintaining dermal-epidermal junction integrity. Ten volunteers with moderate to severe photodamage of dorsal forearm skin were recruited to the study. Using immunohistochemistry, transmission electron microscopy and in situ hybridization, we compared collagen VII protein and mRNA content of photodamaged forearm skin with that of sun-protected hip and upper inner arm skin from the same subjects. Numbers of anchoring fibrils per linear microns of basement membrane (mean +/- SEM) were significantly lower in photodamaged skin (1.79 +/- 0.10) as compared with sun-protected hip (2.28 +/- 0.11) and upper inner arm skin (2.21 +/- 0.10) (P < 0.01), and similarly keratinocyte expression of collagen VII mRNA, quantitated as number of positively stained keratinocytes per high power field, was significantly reduced in photodamaged skin (6.3 +/- 2.5) as compared with sun-protected hip (20.0 +/- 5.6) and upper inner arm skin (17.7 +/- 4.9) (P < 0.001). Semiquantitative assessment of immunohistochemical staining for collagen VII showed a non-significant reduction in photodamaged skin as compared with sun-protected skin. We propose that reduced content of collagen VII in photodamaged skin contributes to wrinkle formation by weakening the bond between the dermis and epidermis.
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Loss of collagen, deterioration of collagen and elastic fibres, and changes to the dermal-epidermal junction may contribute to wrinkle formation.
“It is thought that loss of collagen, deterioration of collagen and elastic fibres and changes to the dermal–epidermal junction may contribute [22,120,158,159,160].”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [158]
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Metadata
- Authors
- CRAVEN, N. M., WATSON, R. E. B., JONES, C. J. P., SHUTTLEWORTH, C. A., KIELTY, C. M., & GRIFFITHS, C. E. M.
- Affiliations
- University of Manchester (GB)
- Corresponding author
- GRIFFITHS, C.E.M.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-09
- Volume
- 137
- Issue
- 3
- Pages
- 344-350
- ISSN
- 0007-0963 (ISSN-L)
- OpenAlex
- W2136652883
- Cited by
- 92
- References
- 1
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- British Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- type VII collagen, photodamage, skin aging, wrinkle formation, anchoring fibrils, basement membrane zone, sun exposure, basement membrane
- MeSH terms
- Aged, Aged, 80 and over, Collagen, Female, Humans, Immunoenzyme Techniques, Male, Microscopy, Electron, Middle Aged, Radiation Injuries, RNA, Messenger, Skin, Sunlight, Skin Aging, Gene Expression, In Situ Hybridization
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