The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Tea tree oil reduces histamine-induced skin inflammation
Abstract
BACKGROUND: Tea tree oil is the essential oil steam-distilled from Melaleuca alternifolia, an Australian native plant. In recent years it has become increasingly popular as an antimicrobial for the treatment of conditions such as tinea pedis and acne. OBJECTIVES: To investigate the anti-inflammatory properties of tea tree oil on histamine-induced weal and flare. METHODS: Twenty-seven volunteers were injected intradermally in each forearm (study and control assigned on an alternating basis) with histamine diphosphate (5 microg in 50 microL). Flare and weal diameters and double skin thickness were measured every 10 min for 1 h to calculate flare area and weal volume. At 20 min, 25 microL of 100% tea tree oil was applied topically to the study forearm of 21 volunteers. For six volunteers, 25 microL paraffin oil was applied instead of tea tree oil. RESULTS: Application of liquid paraffin had no significant effect on histamine-induced weal and flare. There was also no difference in mean flare area between control arms and those on which tea tree oil was applied. However, mean weal volume significantly decreased after tea tree oil application (10 min after tea tree oil application, P = 0.0004, Mann-Whitney U-test). CONCLUSIONS: This is the first study to show experimentally that tea tree oil can reduce histamine-induced skin inflammation.
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“According to the Oxford evidence hierarchy, this study would be classified as Level 3, which includes well‐designed case‐control or cohort studies.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [16]
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Cites
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Self-citationA comparative study of tea‐tree oil versus benzoylperoxide in the treatment of acne
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Brand, C., Ferrante, A., Prager, R. H., Riley, T. V., Carson, C. F., Finlay‐Jones, J. J., & Hart, P. H. (2001) · Inflammation Research · doi:10.1007/s000110050746 · Cited by 157
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TEA TREE OIL IN THE TREATMENT OF TINEA PEDIS
Tong, M. M., Altman, P. M., & Barnetson, R. S. (1992) · Australasian Journal of Dermatology · doi:10.1111/j.1440-0960.1992.tb00103.x · Cited by 122
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Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties
Carson, C. F., Hammer, K. A., & Riley, T. V. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.1.50-62.2006 · Cited by 1,429
Dhifi, W., Bellili, S., Jazi, S., Bahloul, N., & Mnif, W. (2016) · Medicines · doi:10.3390/medicines3040025 · Cited by 1,422
Edris, A. E. (2007) · Phytotherapy Research · doi:10.1002/ptr.2072 · Cited by 1,264
Essential oils used in aromatherapy: A systemic review
Ali, B., Al‐Wabel, N. A., Shams, S., Ahamad, A., Khan, S. A., & Anwar, F. (2015) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/j.apjtb.2015.05.007 · Cited by 1,184
Role of essential oils in food safety: Antimicrobial and antioxidant applications
Bhavaniramya, S., Vishnupriya, S., Al-Aboody, M. S., Vijayakumar, R., & Baskaran, D. (2019) · Grain & Oil Science and Technology · doi:10.1016/j.gaost.2019.03.001 · Cited by 640
Metadata
- Authors
- Koh, K. J., Pearce, A. L., Marshman, G., Finlay-Jones, J. J., & Hart, P. H.
- Affiliations
- Flinders Medical Centre (AU)
- Flinders University (AU)
- Corresponding author
- Hart, P.H.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-12
- Volume
- 147
- Issue
- 6
- Pages
- 1212-1217
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W2070662166
- Cited by
- 185
- References
- 13
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 17 · 2023: 14 · 2022: 7 · 2021: 17 · 2020: 14 · 2019: 6 · 2018: 11 · 2017: 5 · 2016: 9 · 2015: 4 · 2014: 9 · 2013: 8 · 2012: 9
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- tea tree oil, Melaleuca alternifolia, anti-inflammatory activity, topical application, skin thickness, essential oils
- MeSH terms
- Adult, Anti-Inflammatory Agents, Non-Steroidal, Dermatitis, Atopic, Female, Histamine, Humans, Injections, Intradermal, Male, Phytotherapy, Middle Aged, Case-Control Studies, Tea Tree Oil
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