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The safety and effectiveness of deferiprone in a large‐scale, 3‐year study in Italian patients
Open accessAbstract
Summary. In 1997, the Italian Ministry of Health created a special programme for the controlled distribution of deferiprone to collect data and to evaluate its safety and effectiveness in long‐term use. Five hundred and thirty‐two thalassaemia patients from 86 treatment centres were enrolled in this programme. One hundred and eighty‐seven patients (32%) experienced a total of 269 events that led to a temporary interruption or, in some cases, to a discontinuation of treatment. The incidence of agranulocytosis and milder neutropenias were 0·4/100 and 2·1/100 patient‐years respectively. Neutropenia occurred predominantly in younger and non‐splenectomized patients. Transient alanine transaminase increase, gastrointestinal discomfort and arthralgia were the other most commonly reported events. Ferritin levels showed a significant decrease in time after 3 years of therapy. This is the largest number of deferiprone‐treated patients to have been reported to date. These data show that the drug was effective in reducing serum ferritin levels and the incidence of adverse events was not greater than the frequency reported in clinical trials.
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Citations
Cited by
Rund, D., & Rachmilewitz, E. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050436 · Cited by 939
Cao, A., & Galanello, R. (2010) · Genetics in Medicine · doi:10.1097/gim.0b013e3181cd68ed · Cited by 722
Self-citationSafety and effectiveness of long-term therapy with the oral iron chelator deferiprone
Cohen, A. R., Galanello, R., Piga, A., De Sanctis, V., & Tricta, F. (2003) · Blood · doi:10.1182/blood-2002-10-3280 · Cited by 323
Self-citationIron homeostasis and toxicity in retinal degeneration
He, X., Hahn, P., Iacovelli, J., Wong, R., King, C., Bhisitkul, R., Massaro-Giordano, M., & Dunaief, J. L. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2007.07.004 · Cited by 260
Design of iron chelators with therapeutic application
Zhou, T., Ma, Y., Kong, X., & Hider, R. C. (2012) · Dalton Transactions · doi:10.1039/c2dt12159j · Cited by 136
Metadata
- Authors
- Ceci, A., Baiardi, P., Felisi, M., Cappellini, M. D., Carnelli, V., De Sanctis, V., Galanello, R., Maggio, A., Masera, G., Piga, A., Schettini, F., Stefàno, I., & Tricta, F.
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 2002-07
- Volume
- 118
- Issue
- 1
- Pages
- 330-336
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W2039715247
- Cited by
- 215
- References
- 0
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ceci, A., Baiardi, P., Felisi, M., Cappellini, M. D., Carnelli, V., De Sanctis, V., Galanello, R., Maggio, A., Masera, G., Piga, A., Schettini, F., Stefàno, I., & Tricta, F. (2002). The safety and effectiveness of deferiprone in a large‐scale, 3‐year study in Italian patients. British Journal of Haematology. https://doi.org/10.1046/j.1365-2141.2002.03554.x
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