Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase‐3

Ido, Y.; Muto, N.; Inada, A.; Kohroki, J.; Mano, M.; Odani, T.; Itoh, N.; Yamamoto, K.; Tanaka, K.

doi:10.1046/j.1365-2184.1999.3210063.x

Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase‐3

Hinokitiol, a potent iron chelator, has been reported to induce differentiation in teratocarcinoma F9 cells with a reduction of viable cells. In this study, we examined the steps leading to eventual cell death by hinokitiol during differentiation. Hinokitiol induced DNA fragmentation of F9 cells …