The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children
Abstract
Background: The specificity of allergen skin prick testing to diagnose clinically relevant food allergy is controversial. Objectives: To determine the specificity of the allergen weal diameter to correctly identify children who react on formal open food challenges. Methods: Over a 9‐year period children referred to a tertiary allergy clinic for the evaluation of suspected food allergy were prospectively studied. Allergen skin prick testing to cow milk, egg white and peanut extracts (Dome‐Hollister‐Stier, Spokane, WA, USA) was undertaken using a lancet technique. All children underwent open food challenges to the relevant food(s) in a hospital clinic. Challenges were classified as positive, if objective signs were seen; negative, if the child could tolerate normal quantities of the food, daily, for one week; or inconclusive if none of the former criteria were met. Results: Five hundred and fifty‐five challenges were undertaken in 467 children: 339 challenges to cow milk, 121 to egg, and 95 to peanut. Fifty‐five percentage of challenges were positive, 37% negative, and 8% inconclusive. For each food it was possible to identify a skin weal diameter at, and above, which negative reactions did not occur: cow milk, 8 mm; egg, 7 mm; peanut, 8 mm. In contrast, positive reactions could occur with a skin wheal diameter of 0 mm. Conclusions: In this high risk referral population it was possible to define skin weal diameters to egg, milk and peanut above which open oral food challenges were positive (100% specificity). By utilizing these measurements the need for formal food challenges can be reduced.
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Cites
Basic principles of ROC analysis
Metz, C. E. (1978) · Seminars in Nuclear Medicine · doi:10.1016/s0001-2998(78)80014-2 · Cited by 6,026
Sampson, H. A., & Ho, D. G. (1997) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(97)70133-7 · Cited by 1,055
Bock, S. A. (1987) · Pediatrics · doi:10.1542/peds.79.5.683 · Cited by 733
Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: A manual
Allan Bock, S., Sampson, H. A., Atkins, F. M., Zeiger, R. S., Lehrer, S., Sachs, M., Bush, R. K., & Metcafe, D. D. (1988) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(88)90135-2 · Cited by 714
Bindslev‐Jensen, C., Ballmer‐Weber, B. K., Bengtsson, U., Blanco, C., Ebner, C., Hourihane, J., Knulst, A. C., Moneret‐Vautrin, D. A., Nekam, K., Niggemann, B., et al. (2004) · Allergy · doi:10.1111/j.1398-9995.2004.00466.x · Cited by 681
Sampson, H. A., & Albergo, R. (1984) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(84)90083-6 · Cited by 579
Bock, S. A., & Atkins, F. M. (1990) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)80689-4 · Cited by 461
The natural history of peanut allergy
Bock, S. A., & Atkins, F. M. (1989) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(89)90103-6 · Cited by 399
Manifestations of milk allergy in infancy: Clinical and immunologic findings
Hill, D. J., Firer, M. A., Shelton, M. J., & Hosking, C. S. (1986) · The Journal of Pediatrics · doi:10.1016/s0022-3476(86)80384-5 · Cited by 273
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Boyce, J. A., Assa'ad, A., Burks, A. W., Jones, S. M., Sampson, H. A., Wood, R. A., Plaut, M., Cooper, S. F., Fenton, M. J., Arshad, S. H., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.008 · Cited by 2,350
EAACI Molecular Allergology User's Guide
Matricardi, P. M., Kleine‐Tebbe, J., Hoffmann, H. J., Valenta, R., Hilger, C., Hofmaier, S., Aalberse, R. C., Agache, I., Asero, R., Ballmer‐Weber, B., et al. (2016) · Pediatric Allergy and Immunology · doi:10.1111/pai.12563 · Cited by 932
Food allergy: A practice parameter update—2014
Sampson, H. A., Aceves, S., Bock, S. A., James, J., Jones, S., Lang, D., Nadeau, K., Nowak-Wegrzyn, A., Oppenheimer, J., Perry, T. T., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.05.013 · Cited by 845
Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy
Du Toit, G., Katz, Y., Sasieni, P., Mesher, D., Maleki, S. J., Fisher, H. R., Fox, A. T., Turcanu, V., Amir, T., Zadik-Mnuhin, G., et al. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.08.039 · Cited by 834
Allergy Diagnostic Testing: An Updated Practice Parameter
Bernstein, I. L., Li, J. T., Bernstein, D. I., Hamilton, R., Spector, S. L., Tan, R., Sicherer, S., Golden, D. B. K., Khan, D. A., Nicklas, R. A., et al. (2008) · Annals of Allergy, Asthma & Immunology · doi:10.1016/s1081-1206(10)60305-5 · Cited by 723
Metadata
- Authors
- Sporik, R., Hill, D. J., & Hosking, C. S.
- Venue
- Clinical & Experimental Allergy
- Publisher
- Wiley
- Published
- 2000-11
- Volume
- 30
- Issue
- 11
- Pages
- 1541-1546
- ISSN
- 0954-7894 (ISSN-L)
- 1365-2222
- OpenAlex
- W2092317477
- Cited by
- 532
- References
- 24
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
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