Cited by 170Asthma and respiratory diseasesAllergic Rhinitis and SensitizationDermatology and Skin Diseases

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Having lived on a farm and protection against allergic diseases in Australia

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Downs, S. H., Marks, G. B., Mitakakis, T. Z., Lëuppi, J. D., Car, N. G., Peat, J. K.·2001·Clinical & Experimental Allergy

DOI 10.1046/j.1365-2222.2001.01070.x

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Abstract

Background Farmers' children in northern Europe have a lower prevalence of atopy, hay fever and asthma than other children. Farms in Australia differ in scale and operation from those in Europe and the prevalence of allergic diseases in children is higher. Objective To investigate whether having lived on a farm as a child in Australia is associated with a lower risk of allergic diseases. Methods Cross‐sectional study of children (n = 1500) aged 7–12 years from two rural towns: Wagga Wagga in a mixed farming region, and Moree in a crop farming region. Parents answered a questionnaire and children had a skin prick test for atopy. Results Twenty percent of children had lived on a farm for at least 1 year. The effect of having lived on a farm differed between the towns (P < 0.001). It was associated with a lower risk of atopy in Wagga (adjusted odds ratio (aOR) 0.47, 95% confidence interval (CI) 0.32–0.72) but not in Moree (aOR 0.97, 95% CI 0.62–1.53). Children from Wagga were more likely to have lived on a livestock farm than children from Moree (26.1% vs. 9.1%, 95% CI for the difference 8.9–25.4). Conclusion Having lived on a farm in Australia can confer protection against atopy in children. Further studies are needed to identify possible protective mechanisms associated with farm animals or to establish whether the protective effect is explained by other related exposures.

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Authors: Downs, S. H., Marks, G. B., Mitakakis, T. Z., Lëuppi, J. D., Car, N. G., & Peat, J. K.
Affiliations: The University of Sydney (AU)
Charles Sturt University (AU)
Children's Hospital at Westmead (AU)
Corresponding author: Downs, S. H.
ORCID: Marks, G. B.
Venue: Clinical & Experimental Allergy
Publisher: Wiley
Published: 2001-04
Volume: 31
Issue: 4
Pages: 570-575
ISSN: 0954-7894 (ISSN-L)
1365-2222
DOI: 10.1046/j.1365-2222.2001.01070.x
OpenAlex: W2065488410
Cited by: 170
References: 24
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 9 · 2015: 5 · 2014: 3 · 2013: 9 · 2012: 11
FWCI: 7.99
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 286 d)
Locations: Clinical & Experimental Allergy (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Australian Research Council
National Health and Medical Research Council
National Medical Research Council
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords: farm life, childhood atopy, allergic diseases, asthma, allergic rhinitis, livestock exposure, rural children, Wagga Wagga, Moree, skin prick test, mixed farming, crop farming
MeSH terms: Asthma, Australia, Child, Cross-Sectional Studies, Female, Humans, Hypersensitivity, Hypersensitivity, Immediate, Immunization, Male, Surveys and Questionnaires, Risk Factors, Rural Health, Prevalence, Confidence Intervals, Odds Ratio

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