The DOI matches its Crossref record; 16 of the 17 references it cites were found in a registry or an index.
The prevalence of thyroid dysfunction in a population with borderline iodine deficiency
Abstract
OBJECTIVE: We lack information on the influence of borderline iodine deficiency on the occurrence of thyroid dysfunction. Iodine deficiency has been reported to facilitate the development of toxic nodular goitre, whereas a high iodine intake may increase the prevalence of autoimmune hypothyroidism. SUBJECTS AND METHODS: In a cross‐sectional study of a random sample of the general population in our region with borderline iodine defficiency 2656 (65%) of 4073 men and women aged 41 to 71 years participated. Records were made of previous thyroidal illness. Blood samples were drawn for thyroid parameters and TPO Ab values. Iodine and creatinine was assessed in casual urine samples. RESULTS: Previous or present hyperthyroidism was reported by 1.4% of the participants whereas 0.6% had unknown biochemical hyperthyroidism. All cases of undiagnosed hyperthyroidism were among women. Previously diagnosed and treated hypothyroidism was reported by 1.0% and undiagnosed hypothyroidism was found in 0.4%. Subclinical hyperthyroidism was found in 1.3% and subclinical hypothyroidism in 0.7%. TPO Ab titres >200 kU/l were found in 16.9% of the women and 6.6% of the men, and 83% of participants with TSH >5 mU/l had TPO Ab titres >200 kU/l. Participants with TPO Ab titres between 100 and 200 kU/l had no increased frequency of thyroid dysfunction. The median iodine excretion rate was estimated as 103 μg/day. Serum TSH values were higher in women than in men and showed higher dispersion in women as well as in old age. Serum free T3 was found to be higher in women than in men and increased with age. Serum free T4 showed no sex difference but values increased with increasing age. CONCLUSION: In our region with borderline iodine deficiency more than 5% of the general population has clinical or subclinical thyroid dysfunction. We found a relatively high prevalence of hyperthyroidism, especially previously undiagnosed disease, but a low prevalence of hypothyroidism as would be expected in an area of iodine deficiency. Hypothyroidism was related to TPO Ab titres of >200 kU/l. Thyroid hormone levels varied with age and sex.
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“Studies in populations with iodine deficiency have failed to show an increase in TSH [91, 93–95].”
From Age-related variation in thyroid function – a narrative review highlighting important implications for research and clinical practice (2023) · cites this paper as [95]
Citations
Cites
THE SPECTRUM OF THYROID DISEASE IN A COMMUNITY: THE WHICKHAM SURVEY
Tunbridge, W. M. G., Evered, D. C., Hall, R., Appleton, D. R., BREWIS, M., CLARK, F., Evans, J. G., Young, E. T., Bird, T., & Smith, P. (1977) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1977.tb01340.x · Cited by 2,665
Sawin, C. T. (1985) · Archives of Internal Medicine · doi:10.1001/archinte.145.8.1386 · Cited by 439
Laurberg, P., Pedersen, K. M., Hreiðarsson, Á. B., Sigfússon, N., Iversen, E., & Knudsen, P. R. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4624 · Cited by 399
Applications of a New Chemiluminometric Thyrotropin Assay to Subnormal Measurement*
SPENCER, C. A., LoPRESTI, J. S., PATEL, A., GUTTLER, R. B., EIGEN, A., SHEN, D., GRAY, D., & NICOLOFF, J. T. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-2-453 · Cited by 371
LAURBERG, P., PEDERSEN, K. M., VESTERGAARD, H., & SIGURDSSON, G. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00368.x · Cited by 361
Konno, N., Yuri, K., Taguchi, H., Miura, K., Taguchi, S., Hagiwara, K., & Murakami, S. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb01006.x · Cited by 133
Prevalence and incidence of peptic ulcer disease in a Danish County--a prospective cohort study.
Rosenstock, S. J., & Jørgensen, T. (1995) · Gut · doi:10.1136/gut.36.6.819 · Cited by 110
Self-citationEggertsen, R., Petersen, K. L., Lundberg, P. A., Nyström, E., & Lindstedt, G. (1988) · BMJ · doi:10.1136/bmj.297.6663.1586 · Cited by 109
Subclinical hypothyroidism and hyperthyroidism. I. Prevalence and clinical relevance
Wiersinga, W. (1995) · The Netherlands Journal of Medicine · doi:10.1016/0300-2977(94)00089-r · Cited by 88
On the determinants of the creatinine clearance: a population study.
Kesteloot, H., & Jv, J. (1996) · PubMed · Cited by 80
Research works printed but not linked: 1
- Sawin C.T., 1985, The ageing thyroid. Thyroid deficiency in the Framingham study, Archives of Internal Medicine, 145, 1386, 10.1001/archinte.1985.00360080056006 · DOI
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Global epidemiology of hyperthyroidism and hypothyroidism
Taylor, P. N., Albrecht, D., Scholz, A., Gutierrez-Buey, G., Lazarus, J. H., Dayan, C. M., & Okosieme, O. E. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2018.18 · Cited by 1,552
“…same population thyroid antibodies were deteceted in 16% of women and 8% of men 103 figures that are comparable to data from European populations 104 The overall disease burden of hypothyroidism in Sub-Saharan Africa based on largely hospital clinic data, has been generally felt to be minimal,…”
The epidemiology of thyroid disease
Vanderpump, M. P. J. (2011) · British Medical Bulletin · doi:10.1093/bmb/ldr030 · Cited by 1,179
Zimmermann, M. B. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0011 · Cited by 1,071
The Incidence and Prevalence of Thyroid Dysfunction in Europe: A Meta-Analysis
Garmendia Madariaga, A., Santos Palacios, S., Guillén-Grima, F., & Galofré, J. C. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2409 · Cited by 800
“Most of the countries were iodine-sufficient, except in 2 studiesthatinvolvedapopulationwithlongstandingborderline sufficient iodine intake (15, 30) and another study involving long-term exposure to iodine deficiency with no previous iodine prophylaxis (24).”
BackgroundMethodInfluentialThe incidence and prevalence of thyroid autoimmunity
McLeod, D. S. A., & Cooper, D. S. (2012) · Endocrine · doi:10.1007/s12020-012-9703-2 · Cited by 613
Metadata
- Authors
- Knudsen, N., Jørgensen, T., Rasmussen, S., Christiansen, E., & Perrild, H.
- Affiliations
- University of Copenhagen (DK)
- Bispebjerg Hospital (DK)
- Corresponding author
- Knudsen, Nils
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 1999-09
- Volume
- 51
- Issue
- 3
- Pages
- 361-367
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W1979170509
- Cited by
- 153
- References
- 17
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2021: 3 · 2020: 5 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 12 · 2012: 4
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- thyroid dysfunction, hyperthyroidism, hypothyroidism, subclinical hyperthyroidism, subclinical hypothyroidism, thyroid peroxidase antibodies, thyroid-stimulating hormone, iodine excretion, free thyroxine, free triiodothyronine, sex differences, age differences, autoimmune thyroid disease
- MeSH terms
- Adult, Aged, Antibodies, Cross-Sectional Studies, Denmark, Female, Follow-Up Studies, Humans, Hyperthyroidism, Hypothyroidism, Iodide Peroxidase, Iodine, Male, Middle Aged, Thyroid Diseases, Thyrotropin, Thyroxine, Triiodothyronine, Cohort Studies, Prevalence, Logistic Models, Statistics, Nonparametric
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