Human immunodeficiency virus type 1 replication inhibition by the bidentate iron chelators CP502 and CP511 is caused by proliferation inhibition and the onset of apoptosis

Georgiou, N. A.; Van Der Bruggen, T.; Oudshoorn, M.; Hider, R. C.; Marx, J. J. M.; Van Asbeck, B. S.

doi:10.1046/j.1365-2362.2002.0320s1091.x

Human immunodeficiency virus type 1 replication inhibition by the bidentate iron chelators CP502 and CP511 is caused by proliferation inhibition and the onset of apoptosis

Background The iron chelators deferoxamine (DF) and deferiprone (CP20) have been shown to inhibit human immunodeficiency virus type 1 (HIV‐1) replication in human peripheral blood lymphocytes (PBL). The orally active bidentate chelators CP502 and CP511, which also belong to the 3‐hydroxypyridin‐4…