CoChat
Sign Up
Cited by 182Phytase and its ApplicationsMicrobial Metabolites in Food BiotechnologyMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Anti-cancer function of phytic acid

Shamsuddin, Abulkalam M·2002·International Journal of Food Science and Technology
DOI 10.1046/j.1365-2621.2002.00620.x
Open this paper in CoChat — free account

Abstract

Inositol hexaphosphate (InsP6 a.k.a. phytic acid or IP6) is ubiquitous. In the plant kingdom it is particularly abundant in cereals and legumes; in much smaller amounts IP6 and its lower phosphorylated forms (IP(1-5)) are contained in most mammalian cells, where they are important in regulating vital cellular functions. Both in vivo and in vitro experiments have demonstrated striking anticancer (preventive as well as therapeutic) effects of IP6. Inositol also is anti-carcinogenic, albeit to a lesser extent; it acts synergistically IP6 in inhibiting cancer. In addition to reduction in cell proliferation, IP6 increases differentiation of malignant cells often resulting in reversion to the normal phenotype. IP6 is quickly absorbed from the rat stomach and upper intestine and distributed as inositol and IP1. In vitro, it is instantaneously taken up by malignant cells undergoing variable dephosphorylation to inositol and IP(1-5), pointing towards their role in mediating the action of IP6. In humans, IP6 has recently been detected in urine, plasma and other biological fluids; the levels fluctuating with ingestion or deprivation of IP6 or IP6-rich diet. As IP6 is high in high-fibre diets, these also may explain, at least in part, the epidemiological observation showing the association of ingesting high-fibre diets with a lower incidence of certain cancers. Along with safety, the reproducible efficacy of IP6 and inositol in the prevention of cancer in laboratory animals warrant their…

Overview

Integrity signals

Registry

Crossref · 10.1046/j.1365-2621.2002.00620.x

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

  • Diet and Health: What Should We Eat?

    Willett, W. C. (1994) · Science · doi:10.1126/science.8160011 · Cited by 1,008 · cited 1×

    “However, the consistent negative correlation between those high-fibre diets rich in IP6, and cancers of the colon, breast and perhaps prostate are interesting (Englyst et al., 1982; Yu et al., 1991; Willett, 1994).”
    Background

Research works printed but not linked: 61

  1. Babich, 1993, Comparative cytotoxicities of selected minor dietary non-nutrients with chemopreventive properties, Cancer Letters, 73, 127, 10.1016/0304-3835(93)90254-7 · DOI
  2. Barrientos, 1996, Conformationalstudies of myo-inositol phosphates, Carbohydrate Research, 296, 39, 10.1016/S0008-6215(96)00250-9 · DOI
  3. Baten, 1989, Inositol-phosphate-induced enhancement of natural killer cell activity correlates with tumor suppression, Carcinogenesis, 10, 1595, 10.1093/carcin/10.9.1595 · DOI
  4. Chen, 2001, Inositol hexaphosphate inhibits ultraviolet B-induced signal transduction, Molecular Carcinogenesis, 31, 139, 10.1002/mc.1048 · DOI
  5. Cullumbine, 1950, Mineral metabolism on rice diets, British Journal of Nutrition, 4, 101, 10.1079/BJN19500025 · DOI
  6. Eggleton, 1991, Priming action of inositol hexakisphosphate (InsP6) on the stimulated respiratory burst in human neutrophils, Biochimica et Biophysica Acta, 1094, 309, 10.1016/0167-4889(91)90091-B · DOI
  7. El-Sherbiny, 2001, G0/G1 arrest and S phase inhibition of human cancer cell lines by inositol hexaphosphate (IP6), Anticancer Research, 21, 2393
  8. Englyst, 1982, Nonstarch polysaccharide consumption in four Scandinavian populations, Nutrition and Cancer, 4, 50, 10.1080/01635588209513738 · DOI
  9. Estensen, 1993, Studies of chemopreventive effects of myo-inositol on benzo[a]pyrene-induced neoplasia of the lung and forestomach of female A/J mice, Carcinogenesis, 14, 1975, 10.1093/carcin/14.9.1975 · DOI
  10. Graf, 1990, Antioxidant function of phytic acid, Free Radicals in Biology and Medicine, 8, 61, 10.1016/0891-5849(90)90146-A · DOI
  11. Grases, 1998, Effects of phytic acid on renal stone formation in rats, Scandinavian Journal of Urology and Nephrology, 32, 261, 10.1080/003655998750015412 · DOI
  12. Grases, 2000, Urinary phytate in calcium oxalate stone-formers and healthy people. Dietary effects on phytate excretion, Scandinavian Journal of Urology and Nephrology, 34, 162, 10.1080/003655900750016526 · DOI
  13. Grases, 2001, Absorption and excretion of orally administered inositol hexaphosphate (IP6 or phytate) in humans, Biofactors, 15, 53, 10.1002/biof.5520150105 · DOI
  14. Grases, 2001, Variation of InsP4, InsP5 and InsP6 levels in tissues and biological fluids depending on dietary phytate, Journal of Nutritional Biochemistry, 12, 595, 10.1016/S0955-2863(01)00178-4 · DOI
  15. Hanakahi, 2000, Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair, Cell, 102, 721, 10.1016/S0092-8674(00)00061-1 · DOI
  16. Harland, 1987, Phytate in foods, World Review of Nutrition and Diet, 52, 235, 10.1159/000415199 · DOI
  17. Hecht, 1999, Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice, Cancer Letters, 137, 123, 10.1016/S0304-3835(98)00326-7 · DOI
  18. Henneman, 1958, Idiopathic hypercalciuria, New England Journal of Medicine, 17, 802, 10.1056/NEJM195810232591702 · DOI
  19. Holub, 1986, Metabolism and function of myo-inositol and inositol phospholipids, Annual Review of Nutrition, 6, 563, 10.1146/annurev.nu.06.070186.003023 · DOI
  20. Huang, 1997, Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3′ kinase, Cancer Research, 57, 2873
  21. Ishikawa, 1999, Inhibition of skin cancer by IP6in vivo: initiation-promotion model, Anticancer Research, 19, 3749
  22. Jariwalla, 1988, Effect of dietary phytic acid (phytate) on the incidence and growth rate of tumors promoted in Fisher rats by magnesium supplement, Nutrition Research, 1988, 813, 10.1016/S0271-5317(88)80161-1 · DOI
  23. Jariwalla, 1990, Lowering of serum cholesterol and triglycerides and modulations by dietary phytate, Journal of Applied Nutrition, 42, 18
  24. Johnson, 2000, The effects of inositol hexaphosphate on the inflammatory response in transformed RAW 264.7 macrophages, Biomedical Scientific Instrumentation, 36, 21
  25. Kelsay, 1987, Effects of fiber, phytic acid, and oxalic acid in the diet on mineral bioavailability, American Journal of Gastroenterology, 82, 983
  26. Lambertenghi-Deliliers, 2002, Effect of inositol hexaphosphate (IP6) on human normal and leukemic hematopoietic cells, British Journal of Haematology, 117, 1
  27. Larsson, 1997, Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate, Science, 278, 471, 10.1126/science.278.5337.471 · DOI
  28. Levine, 1997, Controlled trials of inositol in psychiatry, European Neuropsychopharmacology, 7, 147, 10.1016/S0924-977X(97)00409-4 · DOI
  29. Ma, 2002, Binding of inositol hexaphosphate (IP6) to Ku but not to DNA-PKcs, Journal of Biological Chemistry, 277, 10756, 10.1074/jbc.C200030200 · DOI
  30. Menniti, 1993, Inositol phosphates and cell signaling: new views of InsP5 and InsP6, TIBS, 18, 53
  31. Morales, 1992, Breast cancer and diet in Spain, Journal of Environmental Pathology, Toxicology and Oncology, 11, 157
  32. O'Halloran, 1993, Transition metals in control of gene expression, Science, 261, 715, 10.1126/science.8342038 · DOI
  33. Ohkawa, 1984, Rice bran treatment for patients with hypercalciuric stones: experimental and clinical studies, Journal of Urology, 132, 1140, 10.1016/S0022-5347(17)50065-8 · DOI
  34. Otake, 1989, Inhibitory effect of inositol hexasulfate and inositol hexaphosphoric acid (phytic acid) on the proliferation of the human immunodeficiency virus (HIV) in vitro [Japanese], Kansenshogaku Zasshi, Journal of the Japanese Association of Infectious Diseases, 63, 676
  35. Rao, 1991, Protection of ischemic heart from reperfusion injury by myo-inositol hexaphosphate, a natural antioxidant, Annals of Thoracic Surgery, 52, 908, 10.1016/0003-4975(91)91254-S · DOI
  36. Sakamoto, 1993, Growth inhibition and differentiation of HT-29 cells in vitro by inositol hexaphosphate (phytic acid), Carcinogenesis, 14, 1815, 10.1093/carcin/14.9.1815 · DOI
  37. Sakamoto, 1993, [3H]Phytic acid (inositol hexaphosphate) is absorbed and distributed to various tissues in rats, Journal of Nutrition, 123, 713, 10.1093/jn/123.4.713 · DOI
  38. Shamsuddin, 1989, Inositol hexaphosphate inhibits large intestinal cancer in F344 rats 5months after induction by azoxymethane, Carcinogenesis, 10, 625, 10.1093/carcin/10.3.625 · DOI
  39. Shamsuddin, 1988, Suppression of large intestinal cancer in F344 rats by inositol hexaphosphate, Carcinogenesis, 9, 577, 10.1093/carcin/9.4.577 · DOI
  40. Shamsuddin, 1989, Inositol and inositol hexaphosphate suppresses cell proliferation and tumor formation in CD-1 mice, Carcinogenesis, 10, 1461, 10.1093/carcin/10.8.1461 · DOI
  41. Shamsuddin, 1992, Effect of inositol hexaphosphate on growth and differentiation in K-562 erythroleukemia cell line, Cancer Letters, 64, 195, 10.1016/0304-3835(92)90043-U · DOI
  42. Szwergold, 1987, Observation of inositol pentakis- and hexakis-phosphates in mammalian tissues by 31P NMR, Biochemical and Biophysical Research Communications, 264, 874, 10.1016/0006-291X(87)90489-X · DOI
  43. Thompson, 1991, Phytic acid and minerals: effect on early markers of risk for mammary and colon carcinogenesis, Carcinogenesis, 12, 2041, 10.1093/carcin/12.11.2041 · DOI
  44. Ullah, 1990, Dose-dependent inhibition of large intestinal cancer by inositol hexaphosphate in F344 rats, Carcinogenesis, 11, 2219, 10.1093/carcin/11.12.2219 · DOI
  45. Vucenik, 1994, [3H]-inositol hexaphosphate (phytic acid) is rapidly absorbed and metabolized by murine and human malignant cells in vitro, Journal of Nutrition, 124, 861, 10.1093/jn/124.6.861 · DOI
  46. Vucenik, 1992, Antitumor activity of phytic acid in murine transplanted and metastatic fibrosarcoma, Cancer Letters, 65, 9, 10.1016/0304-3835(92)90206-B · DOI
  47. Vucenik, 1993, Inhibition of rat mammary carcinogenesis by inositol hexaphosphate (phytic acid), Cancer Letters, 75, 95, 10.1016/0304-3835(93)90193-D · DOI
  48. Vucenik, 1995, Inositol hexaphosphate and inositol inhibit DMBA-induced rat mammary cancer, Carcinogenesis, 16, 1055, 10.1093/carcin/16.5.1055 · DOI
  49. Vucenik, 1997, Comparison of pure inositol hexaphosphate and high-bran diet in the prevention of DMBA-induced rat mammary carcinogenesis, Nutrition and Cancer, 28, 7, 10.1080/01635589709514546 · DOI
  50. Vucenik, 1998, Novel anticancer function of inositol hexaphosphate: inhibition of human rhabdomyosarcoma in vitro and in vivo, Anticancer Research, 18, 1377
  51. Vucenik, 1998, IP6 in treatment of liver cancer I. IP6 inhibits growth and reverses transformed phenotype in HepG2 human liver cancer cell line, Anticancer Research, 18, 4083
  52. Vucenik, 1998, IP6 in treatment of liver cancer II. Intra-tumoral injection of IP6 regresses pre-existing human liver cancer xenotransplanted in nude mice, Anticancer Research, 18, 4091
  53. Vucenik, 1999, Inositol hexaphosphate (IP6) differentially modulates the expression of PKC* in MCF-7 and MDA-MB 231 cells, Proceedings of the American Association for Cancer Research, 40, 653
  54. Vucenik, 1999, Antiplatelet activity of inositol hexaphosphate (IP6), Anticancer Research, 19, 3689
  55. Walker, 1948, Studies in human mineral metabolism. I. The effect of bread rich in phytate phosphorous on the metabolism of certain mineral salts with special reference to calcium, Biochemistry Journal, 42, 452, 10.1042/bj0420452 · DOI
  56. Wattenberg, 1996, Chemopreventive effects of myo-inositol and dexamethasone on benzo[a]pyrene and 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone-induced pulmonary carcinogenesis in female A/J mice, Cancer Research, 56, 5132
  57. Yang, 1995, IP6-induced growth inhibition and differentiation of HT-29 human colon cancer cells: involvement of intracellular inositol phosphates, Anticancer Research, 15, 2479
  58. York, 1999, A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export, Science, 285, 96, 10.1126/science.285.5424.96 · DOI
  59. Yu, 1991, Comparative epidemiology of cancers of the colon, rectum, prostate and breast in Shanghai, China versus the United States, International Journal of Epidemiology, 20, 76, 10.1093/ije/20.1.76 · DOI
  60. Zang, 1994, Differences in nutritional risk factors for breast cancer among New York City White, Hispanic, and Black college students, Ethnicity and Disease, 4, 28
  61. Zi, 2000, Impairment of erbB1 receptor and fluid-phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU 145 cells, Carcinogenesis, 21, 2225, 10.1093/carcin/21.12.2225 · DOI

Cited by

Sorted by citations

See all 182

Metadata

Authors
Shamsuddin, A. M.
Affiliations
University of Maryland, Baltimore (US)
Corresponding author
Shamsuddin, Abulkalam M
ORCID
Shamsuddin, Abulkalam M
Venue
International Journal of Food Science and Technology
Publisher
Oxford University Press (OUP)
Published
2002-09-23
Volume
37
Issue
7
Pages
769-782
ISSN
  • 0950-5423 (ISSN-L)
  • 1365-2621
DOI
10.1046/j.1365-2621.2002.00620.x
OpenAlex
W2099176354
Cited by
182
References
74
Citations by year
2026: 4 · 2025: 6 · 2024: 2 · 2023: 13 · 2022: 9 · 2021: 9 · 2020: 9 · 2019: 3 · 2018: 8 · 2017: 17 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 9 · 2012: 15
FWCI
7.58
Type
journal article
Language
en
Open access
closed
Licence
Locations
International Journal of Food Science & Technology (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytase and its Applications
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
phytic acid, myo-inositol, anticancer activity, cancer prevention, cancer therapy, cell differentiation, cell proliferation, high-fiber diet, dietary intake, cereals, Fabaceae

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review