The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth
Open accessAbstract
Legionella pneumophila is a bacterial pathogen that can enter the human lung and grow inside alveolar macrophages. To grow within phagocytic host cells, the bacteria must create a specialized organelle that restricts fusion with lysosomes. Biogenesis of this replicative organelle is controlled by 24 dot and icm genes, which encode a type IV‐related transport apparatus. To understand how this transporter functions, isogenic L. pneumophila dot and icm mutants were characterized, and three distinct phenotypic categories were identified. Our data show that, in addition to genes that encode the core Dot/Icm transport apparatus, subsets of genes are required for pore formation and modulation of phagosome trafficking. To understand activities required for virulence at a molecular level, we investigated protein–protein interactions. Specific interactions between different Icm proteins were detected by yeast two‐hybrid and gel overlay analysis. These data support a model in which the IcmQ–IcmR complex regulates the formation of a translocation channel that delivers proteins into host cells, and the IcmS–IcmW complex is required for export of virulence determinants that modulate phagosome trafficking.
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Horwitz, M. A., & Silverstein, S. C. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109874 · Cited by 639
Cited by
NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease
Chen, G., Shaw, M. H., Kim, Y.-G., & Nuñez, G. (2009) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092239 · Cited by 772
Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf
Amer, A., Franchi, L., Kanneganti, T.-D., Body-Malapel, M., Özören, N., Brady, G., Meshinchi, S., Jagirdar, R., Gewirtz, A., Akira, S., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604933200 · Cited by 453
Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites
Kagan, J. C., & Roy, C. R. (2002) · Nature Cell Biology · doi:10.1038/ncb883 · Cited by 444
Self-citationModulation of Host Cell Function by Legionella pneumophila Type IV Effectors
Hubber, A., & Roy, C. R. (2010) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100109-104034 · Cited by 431
Self-citationNagai, H., Cambronne, E. D., Kagan, J. C., Amor, J. C., Kahn, R. A., & Roy, C. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406239101 · Cited by 283
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Metadata
- Authors
- Coers, J., Kagan, J. C., Matthews, M., Nagai, H., Zuckman, D. M., & Roy, C. R.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2000-11
- Volume
- 38
- Issue
- 4
- Pages
- 719-736
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2080563387
- Cited by
- 179
- References
- 1
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Coers, J., Kagan, J. C., Matthews, M., Nagai, H., Zuckman, D. M., & Roy, C. R. (2000). Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.2000.02176.x
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