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The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae
Open accessAbstract
The Saccharomyces cerevisiae FPS1 gene encodes a glycerol channel protein involved in osmoregulation. We present evidence that Fps1p mediates influx of the trivalent metalloids arsenite and antimonite in yeast. Deletion of FPS1 improves tolerance to arsenite and potassium antimonyl tartrate. Under high osmolarity conditions, when the Fps1p channel is closed, wild‐type cells show the same degree of As(III) and Sb(III) tolerance as the fps1 Δ mutant. Additional deletion of FPS1 in mutants defective in arsenite and antimonite detoxification partially suppresses their hypersensitivity to metalloid salts. Cells expressing a constitutively open form of the Fps1p channel are highly sensitive to both arsenite and antimonite. We also show by direct transport assays that arsenite uptake is mediated by Fps1p. Yeast cells appear to control the Fps1p‐mediated pathway of metalloid uptake, as expression of the FPS1 gene is repressed upon As(III) and Sb(III) addition. To our knowledge, this is the first report describing a eukaryotic uptake mechanism for arsenite and antimonite and its involvement in metalloid tolerance.
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Citations
Cited by
Antimicrobial activity of metals: mechanisms, molecular targets and applications
Lemire, J. A., Harrison, J. J., & Turner, R. J. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3028 · Cited by 2,746
Osmotic Stress Signaling and Osmoadaptation in Yeasts
Hohmann, S. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.300-372.2002 · Cited by 1,767
Microbial arsenic: from geocycles to genes and enzymes
Mukhopadhyay, R., Rosen, B. P., Phung, L. T., & Silver, S. (2002) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2002.tb00617.x · Cited by 726
Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9
Liu, Z., Shen, J., Carbrey, J. M., Mukhopadhyay, R., Agre, P., & Rosen, B. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092131899 · Cited by 505
Root Iron Plaque on Wetland Plants as a Dynamic Pool of Nutrients and Contaminants
Khan, N., Seshadri, B., Bolan, N., Saint, C. P., Kirkham, M. B., Chowdhury, S., Yamaguchi, N., Lee, D. Y., Li, G., Kunhikrishnan, A., et al. (2016) · Advances in Agronomy · doi:10.1016/bs.agron.2016.04.002 · Cited by 194
Metadata
- Authors
- Wysocki, R., Chéry, C. C., Wawrzycka, D., Van Hulle, M., Cornelis, R., Thevelein, J. M., & Tamás, M. J.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2001-06
- Volume
- 40
- Issue
- 6
- Pages
- 1391-1401
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W1999165043
- Cited by
- 327
- References
- 0
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wysocki, R., Chéry, C. C., Wawrzycka, D., Van Hulle, M., Cornelis, R., Thevelein, J. M., & Tamás, M. J. (2001). The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.2001.02485.x
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