The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Essential role of DivIVA in polar growth and morphogenesis in Streptomyces coelicolor A3(2)
Open accessAbstract
Summary: Streptomycetes grow by cell wall extension at hyphal tips. The molecular basis for such polar growth in prokaryotes is largely unknown. It is reported here that DivIVA SC, the Streptomyces coelicolor homologue of the Bacillus subtilis protein DivIVA, is essential and directly involved in hyphal tip growth and morphogenesis. A DivIVA SC‐EGFP hybrid was distinctively localized to hyphal tips and lateral branches. Reduction of divIVASC expression to about 10% of the normal level produced a phenotype strikingly similar to that of many tip growth mutants in fungi, including irregular curly hyphae and apical branching. Overexpression of the gene dramatically perturbed determination of cell shape at the growing tips. Furthermore, staining of nascent peptidoglycan with a fluorescent vancomycin conjugate revealed that induction of overexpression in normal hyphae disturbed tip growth, and gave rise to several new sites of cell wall assembly, effectively causing hyperbranching. The results show that DivIVA SC is a novel bacterial morphogene, and it is localized at or very close to the apical sites of peptidoglycan assembly in Streptomyces hyphae.
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Cites
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Lupas, A., Van Dyke, M., & Stock, J. (1991) · Science · doi:10.1126/science.252.5009.1162 · Cited by 3,953
Genes required for mycobacterial growth defined by high density mutagenesis
Sassetti, C. M., Boyd, D. H., & Rubin, E. J. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03425.x · Cited by 2,544
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Cited by
Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium
Flärdh, K., & Buttner, M. J. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro1968 · Cited by 667
Self-citationBacterial solutions to multicellularity: a tale of biofilms, filaments and fruiting bodies
Claessen, D., Rozen, D. E., Kuipers, O. P., Søgaard-Andersen, L., & van Wezel, G. P. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3178 · Cited by 488
Bacterial Growth and Cell Division: a Mycobacterial Perspective
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Metadata
- Authors
- Flärdh, K.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2003-08-11
- Volume
- 49
- Issue
- 6
- Pages
- 1523-1536
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W1940534623
- Cited by
- 227
- References
- 3
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Flärdh, K. (2003). Essential role of DivIVA in polar growth and morphogenesis in Streptomyces coelicolor A3(2). Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.2003.03660.x
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