CoChat
Sign Up
Cited by 120

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis

Porto, Aurélia F., Neva, Franklin A., Bittencourt, Helito, Lisboa, Waldir, Thompson, Robert, Alcântara, Luís, Carvalho, Edgar M.·2001·Parasite Immunology
DOI 10.1046/j.1365-3024.2001.00407.x
Open this paper in CoChat — free account

Abstract

Eosinophils, immunoglobilin (Ig)E and cytokines have important roles in defence mechanisms against helminths. In this study, the influence of HTLV‐1 infection, characterized by a Th1 type of immune response, was evaluated on the cytokine pattern and parasitic specific IgE response in patients with strongyloidiasis. Patients were divided into four groups: strongyloidiasis without HTLV‐1 infection, strongyloidiasis with HTLV‐1, HTLV‐1 without strongyloidiasis and controls without either helminth infection or HTLV‐1. The cytokine profile was determined in supernatants of mononuclear cells stimulated with Strongyloides stercoralis crude antigen and the parasite specific IgE was measured by ELISA. Patients coinfected with HTLV‐1 had higher levels of interfron (IFN)‐γ and interleukin (IL)‐10 (P < 0·05) and lower levels of IL‐5 and IgE (P < 0·05) than patients with strongyloidiasis without HTLV‐1. There was an inverse relationship between IFN‐γ and IL‐5 (P = 0·01; rs = − 0·37) and between IFN‐γ and parasite specific IgE (P = 0·01; rs = − 0·39), and a direct relationship between IFN‐γ and IL‐10 (P = 0·04; rs = 0·35). These data show that coinfection with HTLV‐1 decreases IL‐5 and IgE responses in patients with strongyloidiasis consistent with a relative switch from Th2 to Th1 response. Immunological responses such as these are important in the control of this helminthic infection.

Overview

Integrity signals

Registry

Crossref · 10.1046/j.1365-3024.2001.00407.x

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 39

  1. 10.1016/S0140-6736(84)91030-4 · DOI
  2. 10.1093/infdis/169.3.692 · DOI
  3. 10.4269/ajtmh.1997.56.71 · DOI
  4. 10.1093/ajcp/107.1.81 · DOI
  5. 10.1016/0035-9203(94)90499-5 · DOI
  6. 10.1097/00000441-199110000-00006 · DOI
  7. 10.1016/0002-9343(92)90113-P · DOI
  8. Patey O, 1992, Seven years of recurrent severe strongyloidiasis in an HTLV‐I‐infected man who developed adult T‐cell leukaemia, J Acq Immun Def Syndr Hum Retrovirol, 6, 575
  9. 10.4269/ajtmh.1999.60.146 · DOI
  10. 10.1086/314507 · DOI
  11. 10.1126/science.6093248 · DOI
  12. Höllsberg P, 1992, Characterization of HTLV‐1 in vivo infected T cell clones. IL‐2‐Independent growth of non transformed T cells, J Immunol, 148, 3256, 10.4049/jimmunol.148.10.3256 · DOI
  13. 10.3109/10428199709050884 · DOI
  14. 10.1126/science.2787531 · DOI
  15. 10.1172/JCI116752 · DOI
  16. 10.1016/0020-7519(94)90159-7 · DOI
  17. 10.1002/eji.1830270410 · DOI
  18. 10.1046/j.1365-3024.1997.d01-142.x · DOI
  19. Mcrury J, 1986, Specific IgE responses in human strongyloidiasis, Clin Exp Immunol, 65, 631
  20. 10.1590/S0036-46651993000400010 · DOI
  21. Ahmad A, 1991, A role for IgE in intestinal immunity. Expression of rapid expulsion of Trichinella spiralis in rats transfused with IgE and thoracic duct lymphocytes, J Immunol, 146, 3563, 10.4049/jimmunol.146.10.3563 · DOI
  22. Madden KB, 1991, Antibodies to IL‐3 and IL‐4 suppress helminth induced mastocytosis, J Immunol, 147, 1387, 10.4049/jimmunol.147.4.1387 · DOI
  23. Urban JFJ, 1995, IL‐4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice, J Immunol, 154, 4675, 10.4049/jimmunol.154.9.4675 · DOI
  24. Goldhill J, 1997, Interleukin‐4 modulates cholinergic neural control of mouse small intestinal longitudinal muscle, Am J Physiol, 272, G1135
  25. 10.1016/S0960-9822(98)70256-8 · DOI
  26. Russo DM, 1992, Stimulation of human T lymphocyte by Leishmania, J Immunol, 148, 202, 10.4049/jimmunol.148.1.202 · DOI
  27. 10.1007/BF02591635 · DOI
  28. 10.1016/0008-8749(90)90052-S · DOI
  29. 10.1084/jem.170.6.2081 · DOI
  30. 10.4049/jimmunol.149.7.2378 · DOI
  31. 10.1111/j.1600-065X.2008.00711.x · DOI
  32. Sher A, 1991, Production of IL‐10 by CD4+ T lymphocytes correlates with down‐regulation of Th1 cytokine synthesis in helminthic infection, J Immunol, 147, 2713, 10.4049/jimmunol.147.8.2713 · DOI
  33. Taga K, 1992, IL‐10 inhibit T cell proliferation and IL‐2 production, J Immunol, 148, 1143, 10.4049/jimmunol.148.4.1143 · DOI
  34. 10.1146/annurev.immunol.15.1.505 · DOI
  35. 10.1016/S0167-5699(05)80018-0 · DOI
  36. 10.1046/j.1365-3024.1999.00204.x · DOI
  37. Capron M, 1978, Rat mast cell–eosinophil interaction in antibody‐dependent eosinophil cytotoxicity to Schistosoma mansoni schistosomula, J Immunol, 121, 2518, 10.4049/jimmunol.121.6.2518 · DOI
  38. 10.1016/0035-9203(83)90162-1 · DOI
  39. 10.1097/00042560-199806010-00013 · DOI

Cited by

Sorted by citations

See all 120

Metadata

Authors
Porto, A. F., Neva, F. A., Bittencourt, H., Lisboa, W., Thompson, R., Alcântara, L., & Carvalho, E. M.
Venue
Parasite Immunology
Publisher
Wiley
Published
2001-09
Volume
23
Issue
9
Pages
503-507
ISSN
  • 0141-9838
  • 1365-3024
DOI
10.1046/j.1365-3024.2001.00407.x
Cited by
120
References
1
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 111 d)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review