The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Two MAPK cascades, NPR1, and TGA transcription factors play a role in Pto‐mediated disease resistance in tomato
Open accessAbstract
Summary: The tomato Pto kinase confers resistance to the causative agent of bacterial speck disease, Pseudomonas syringae pv. tomato, by recognizing the pathogen effector proteins AvrPto or AvrPtoB. Pto‐mediated resistance requires multiple signal transduction pathways and has been shown to activate many defense responses including an oxidative burst, rapid changes in the expression of over 400 genes, and localized cell death. We have tested the role in Pto‐mediated resistance in tomato of a set of 21 genes from other species known to be involved in defense‐related signaling. Expression of each gene was suppressed by virus‐induced gene silencing (VIGS) and the effect on disease symptoms and bacterial growth during the tomato–Pseudomonas incompatible interaction was determined. We found that Pto‐mediated resistance was compromised by silencing of genes encoding two mitogen‐activated protein (MAP) kinase kinases, MEK1 and MEK2, two MAP kinases, NTF6 and wound‐induced protein kinase (WIPK), a key regulator of systemic acquired resistance (SAR), NPR1, and two transcription factors, TGA1a and TGA2.2. A lesser impact on Pto‐mediated resistance was observed in plants silenced for RAR1 and COI1. The identification of nine genes that play a role in resistance to bacterial speck disease both advances our knowledge of Pto signal transduction and demonstrates the conservation of many defense signaling components among diverse plant species.
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Mammalian MAP kinase signalling cascades
Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,111
Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237
Plant pathogens and integrated defence responses to infection
Dangl, J. L., & Jones, J. D. G. (2001) · Nature · doi:10.1038/35081161 · Cited by 3,949
Biochemistry and molecular biology of plants
Short, T. W. (2001) · Biochemistry and Molecular Biology Education · Cited by 3,833
THE OXIDATIVE BURST IN PLANT DISEASE RESISTANCE
Lamb, C., & Dixon, R. A. (1997) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.48.1.251 · Cited by 3,213
The WRKY superfamily of plant transcription factors
Eulgem, T., Rushton, P. J., Robatzek, S., & Somssich, I. E. (2000) · Trends in Plant Science · doi:10.1016/s1360-1385(00)01600-9 · Cited by 3,035
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
WIDMANN, C., GIBSON, S., JARPE, M. B., & JOHNSON, G. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.143 · Cited by 2,729
MAP kinase signalling cascade in Arabidopsis innate immunity
Asai, T., Tena, G., Plotnikova, J., Willmann, M. R., Chiu, W.-L., Gomez-Gomez, L., Boller, T., Ausubel, F. M., & Sheen, J. (2002) · Nature · doi:10.1038/415977a · Cited by 2,726
Expression profiling reveals off-target gene regulation by RNAi
Jackson, A. L., Bartz, S. R., Schelter, J., Kobayashi, S. V., Burchard, J., Mao, M., Li, B., Cavet, G., & Linsley, P. S. (2003) · Nature Biotechnology · doi:10.1038/nbt831 · Cited by 2,370
Virus‐induced gene silencing in tomato
Liu, Y., Schiff, M., & Dinesh‐Kumar, S. P. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01394.x · Cited by 1,654
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Emerging MAP kinase pathways in plant stress signalling
Nakagami, H., Pitzschke, A., & Hirt, H. (2005) · Trends in Plant Science · doi:10.1016/j.tplants.2005.05.009 · Cited by 676
Evolution of Hormone Signaling Networks in Plant Defense
Berens, M. L., Berry, H. M., Mine, A., Argueso, C. T., & Tsuda, K. (2017) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-080516-035544 · Cited by 563
Kandoth, P. K., Ranf, S., Pancholi, S. S., Jayanty, S., Walla, M. D., Miller, W., Howe, G. A., Lincoln, D. E., & Stratmann, J. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700344104 · Cited by 275
Silencing GhNDR1 and GhMKK2 compromises cotton resistance to Verticillium wilt
Gao, X., Wheeler, T., Li, Z., Kenerley, C. M., He, P., & Shan, L. (2011) · The Plant Journal · doi:10.1111/j.1365-313x.2011.04491.x · Cited by 268
Wang, Y., Cai, S., Yin, L., Shi, K., Xia, X., Zhou, Y., Yu, J., & Zhou, J. (2015) · Autophagy · doi:10.1080/15548627.2015.1098798 · Cited by 230
Metadata
- Authors
- Ekengren, S. K., Liu, Y., Schiff, M., Dinesh‐Kumar, S. P., & Martin, G. B.
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 2003-11-25
- Volume
- 36
- Issue
- 6
- Pages
- 905-917
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W2123769370
- Cited by
- 353
- References
- 71
- FWCI
- 21.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ekengren, S. K., Liu, Y., Schiff, M., Dinesh‐Kumar, S. P., & Martin, G. B. (2003). Two MAPK cascades, NPR1, and TGA transcription factors play a role in Pto‐mediated disease resistance in tomato. The Plant Journal. https://doi.org/10.1046/j.1365-313x.2003.01944.x
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