Two B or not two B? overview of the rapidly expanding B-box family of proteins
Abstract
The B-box gene family represents a large number of genes involved in functions such as axial patterning, growth control, differentiation, and transcriptional regulation. These genes possess several conserved motifs that always include a B-box zinc binding motif associated with various other motifs such as the RING zinc finger, an alpha-helical coiled-coil, the rfp or B30.2 motif, propeller domain, and the NHL motif in various combinations. Mutations or rearrangements in several B-box family members are associated with human diseases and cancers such as familial Mediterranean fever (FMF), Optiz/BBB syndrome, acute promyelocytic leukemia, mulibrey nanism, and thyroid carcinomas. This suggests that members of this gene family play important roles in fundamental biological processes. Here we discuss the known members of this rapidly expanding protein family.
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TRIM32 is a member of the TRIM, or RING-B-box-coiled-coil, protein family.
“TRIM32 is a member of a growing family of TRIM, or RING-B-box-coiled-coil, proteins”
From Limb-Girdle Muscular Dystrophy Type 2H Associated with Mutation in TRIM32, a Putative E3-Ubiquitin–Ligase Gene (2002) · cites this paper as Torok and Etkin 2001
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Fridell, R. A., Harding, L. S., Bogerd, H. P., & Cullen, B. R. (1995) · Virology · doi:10.1006/viro.1995.1266 · Cited by 129 · see citing works
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Frosk, P., Weiler, T., Nylen, E., Sudha, T., Greenberg, C. R., Morgan, K., Fujiwara, T. M., & Wrogemann, K. (2002) · The American Journal of Human Genetics · doi:10.1086/339083 · Cited by 261 · see citing works
- Authors
- Torok, M., & Etkin, L. D.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Etkin, Laurence D.
- Venue
- Differentiation
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 67
- Issue
- 3
- Pages
- 63-71
- ISSN
- 0301-4681 (ISSN-L)
- OpenAlex
- W2151136575
- Cited by
- 169
- References
- 1
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 9 · 2023: 8 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 11 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 10
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Differentiation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Institutes of Health
- National Cancer Institute (T32CA009299, T32 CA09299-21)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- B-box proteins, zinc-binding motif, coiled-coil domain, familial Mediterranean fever, acute promyelocytic leukemia, Mulibrey nanism, thyroid cancer, transcriptional regulation, axial patterning
- MeSH terms
- Animals, Cell Differentiation, Genes, Homeobox, Humans, Mutation, Neoplasms, Zinc, Zinc Fingers, Conserved Sequence, Protein Structure, Secondary, Homeodomain Proteins, Amino Acid Motifs
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