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Synthetic bone graft substitutes
Open accessAbstract
Replacement of extensive local bone loss is a significant clinical challenge. There are a variety of techniques available to the surgeon to manage this problem, each with their own advantages and disadvantages. It is well known that there is morbidity associated with harvesting of autogenous bone graft and limitations in the quantity of bone available. Alternatively allografts have been reported to have a significant incidence of postoperative infection and fracture as well as the potential risk of disease transmission. During the past 30 years a variety of synthetic bone graft substitutes has been developed with the aim to minimize these complications. The benefits of synthetic grafts include availability, sterility and reduced morbidity. The present article examines the relevance of synthetic bone graft substitutes, their mechanical properties and clinical application.
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Cited by
A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2
James, A. W., LaChaud, G., Shen, J., Asatrian, G., Nguyen, V., Zhang, X., Ting, K., & Soo, C. (2016) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2015.0357 · Cited by 1,131
Osteoinduction of bone grafting materials for bone repair and regeneration
García-Gareta, E., Coathup, M. J., & Blunn, G. W. (2015) · Bone · doi:10.1016/j.bone.2015.07.007 · Cited by 649
Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments
Zhao, R., Yang, R., Cooper, P. R., Khurshid, Z., Shavandi, A., & Ratnayake, J. (2021) · Molecules · doi:10.3390/molecules26103007 · Cited by 641
Kao, S. T., & Scott, D. D. (2007) · Oral and Maxillofacial Surgery Clinics of North America · doi:10.1016/j.coms.2007.06.002 · Cited by 263
Kang, Y., Xu, C., Meng, L., Dong, X., Qi, M., & Jiang, D. (2022) · Bioactive materials · doi:10.1016/j.bioactmat.2022.02.012 · Cited by 253
“Despite the self-healing capability of bone, larger bone defects are preferentially treated with autologous bone grafting, however, limited bone supply and donor site morbidity are major disadvantages of this approach [2].”
Background
Metadata
- Authors
- Moore, W. R., Graves, S. E., & Bain, G. I.
- Venue
- ANZ Journal of Surgery
- Publisher
- Wiley
- Published
- 2001-06-08
- Volume
- 71
- Issue
- 6
- Pages
- 354-361
- ISSN
- 1445-1433 (ISSN-L)
- 1445-2197
- OpenAlex
- W2142057495
- Cited by
- 826
- References
- 0
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Moore, W. R., Graves, S. E., & Bain, G. I. (2001). Synthetic bone graft substitutes. ANZ Journal of Surgery. https://doi.org/10.1046/j.1440-1622.2001.02128.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
