The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Ischemic rat brain extracts induce human marrow stromal cell growth factor production
Abstract
Intravenous administration of human bone marrow stromal cells (hMSCs) after middle cerebral artery occlusion (MCAo) in rats provides functional benefit. We tested the hypothesis that these functional benefits are derived in part from hMSC production of growth and trophic factors. Quantitative sandwich enzyme‐linked immunosorbent assay (ELISA) of hMSCs cultured with normal and MCAo brain extracts were performed. hMSCs cultured in supernatant derived from ischemic brain extracts increased production of brain‐derived neurotrophic factor (BDNF), nerve growth factor (NGF), vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF). These neurotrophins and angiogenic growth factors increased in a post‐ischemia time‐dependent manner. The hMSC capacity to increase expression of growth and trophic factors may be the key to the benefit provided by transplanted hMSCs in the ischemic brain.
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Cites
VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain
Zhang, Z. G., Zhang, L., Jiang, Q., Zhang, R., Davies, K., Powers, C., Bruggen, N. V., & Chopp, M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9369 · Cited by 1,296
Self-citationSondell, M., Lundborg, G., & Kanje, M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05731.1999 · Cited by 750
Cited by
Gu, X., Ding, F., Yang, Y., & Liu, J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.11.002 · Cited by 583
Chen, J., Li, Y., Katakowski, M., Chen, X., Wang, L., Lu, D., Lu, M., Gautam, S. C., & Chopp, M. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10691 · Cited by 578
Self-citationMesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy
Baglio, S. R., Pegtel, D. M., & Baldini, N. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00359 · Cited by 542
Turturici, G., Tinnirello, R., Sconzo, G., & Geraci, F. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00228.2013 · Cited by 483
Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury
Parr, A. M., Tator, C. H., & Keating, A. (2007) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705757 · Cited by 447
Metadata
- Authors
- Chen, X., Li, Y., Wang, L., Katakowski, M., Zhang, L., Chen, J., Xu, Y., Gautam, S. C., & Chopp, M.
- Venue
- Neuropathology
- Publisher
- Wiley
- Published
- 2002-12
- Volume
- 22
- Issue
- 4
- Pages
- 275-279
- ISSN
- 0919-6544 (ISSN-L)
- 1440-1789
- OpenAlex
- W2051755309
- Cited by
- 382
- References
- 2
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, X., Li, Y., Wang, L., Katakowski, M., Zhang, L., Chen, J., Xu, Y., Gautam, S. C., & Chopp, M. (2002). Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Neuropathology. https://doi.org/10.1046/j.1440-1789.2002.00450.x
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