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Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state: Dose‐finding study with no concomitant use of hypnotic agent
Open accessAbstract
This was the first dose‐finding study of trazodone that was designed to be free of the concomitant use of hypnotics, in which the drug was administered in a single dose for sleep disorders combined with a depressive state. As a result, trazodone at the dosage of 50–100 mg/day improved sleep disorders, particularly at the 100 mg/day dosage. It was confirmed that trazodone improved sleep disorders combined with a depressive state when it was administered in a single dose before bedtime with no concomitant hypnotics.
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Sleep scores on HAMD were significantly better improved for trazodone (50-100mg) than placebo, although the effect was better in lower doses.
“(Mashiko et al., 1999) found that sleep scores on HAMD were significantly better improved for trazodone (50-100mg) than placebo, although the effect was better in lower doses.”
From Antidepressants and their effect on sleep (2005) · cites this paper as Mashiko et al., 1999
The Methods describe three trazodone dose groups (50, 75, and 100 mg/day), with no placebo group. The Discussion says 100 mg/day was most effective for sleep disorders, contrary to the claim that lower doses worked better. The Results report improvement in HRSD sleep items but do not establish a comparison with placebo. (LLM, conf=0.90)
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Research works printed but not linked: 2
- 10.1007/BF00432013 · DOI
- 10.1176/ajp.151.7.1069 · DOI · Paper page
Cited by
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Antidepressants and their effect on sleep
Mayers, A. G., & Baldwin, D. S. (2005) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.726 · Cited by 323
Antidepressant Medication Prescribing Practices for Treatment of Major Depressive Disorder
Treviño, L. A., Ruble, M. W., Treviño, K., Weinstein, L. M., & Gresky, D. P. (2017) · Psychiatric Services · doi:10.1176/appi.ps.201600087 · Cited by 25
Metadata
- Authors
- Mashiko, H., Niwa, S., Kumashiro, H., Kaneko, Y., Suzuki, S., Numata, Y., Horikoshi, R., & Watanabe, Y.
- Affiliations
- Fukushima Medical University (JP)
- Shirakawa Kosei General Hospital (JP)
- Fukushima Red Cross Hospital (JP)
- Fukuchiyama City Hospital (JP)
- Corresponding author
- Mashiko, Hirobumi
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 1999-04
- Volume
- 53
- Issue
- 2
- Pages
- 193-194
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W1995128400
- Cited by
- 35
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2020: 1 · 2018: 5 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- trazodone, sleep disorders, depression, insomnia, dose-finding, single-dose administration, bedtime dosing
- MeSH terms
- Adult, Depressive Disorder, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Personality Inventory, Trazodone, Treatment Outcome, Antidepressive Agents, Second-Generation
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